HIPHOP chemogenomics database
YER049W / TPA1 
Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER049W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.167 | 2.95E-22 | YMR111C | YMR111C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress |
| 0.157 | 5.53E-20 | YJL068C | YJL068C | hom | Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D |
| 0.154 | 3.08E-19 | YMR210W | YMR210W | hom | Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification |
| 0.144 | 4.83E-17 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |
| 0.133 | 1.26E-14 | YOR012W_p | YOR012W_p | hom | Putative protein of unknown function |
| 0.131 | 2.28E-14 | YOR010C | TIR2 | hom | Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis |
| 0.130 | 3.79E-14 | YMR039C | SUB1 | hom | Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress |
| 0.130 | 4.93E-14 | YDL171C | GLT1 | hom | NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source |
| 0.124 | 5.67E-13 | YCR072C | RSA4 | het | WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus |
| 0.122 | 1.24E-12 | YLL046C | RNP1 | hom | Ribonucleoprotein that contains two RNA recognition motifs (RRM) |
| 0.119 | 4.41E-12 | YNL312W | RFA2 | het | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress |
| 0.119 | 4.49E-12 | YER064C | VHR2 | hom | Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
| 0.118 | 7.13E-12 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.116 | 1.71E-11 | YGR127W_p | YGR127W_p | hom | Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response |
| 0.115 | 2.18E-11 | YGL149W_d | YGL149W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. |