YER055C / HIS1

ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

Zygosity: Homozygous strain
fixedexpanded
Profile for YER055C / HIS1

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:3.99|P-value:4.07E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.99|P-value:4.00E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.21|P-value:7.52E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.27|P-value:1.36E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.18|P-value:9.09E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:5.26|P-value:1.03E-7 ID:SGTC_553|Compound:k007-0256|FD-Score:3.33|P-value:4.86E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.88|P-value:6.27E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.85|P-value:6.90E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.14|P-value:9.30E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.58|P-value:2.00E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-6.37|P-value:1.81E-10 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.99|P-value:4.11E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.31|P-value:5.35E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-6.13|P-value:8.19E-10 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.42|P-value:3.92E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.84|P-value:8.08E-5 ID:SGTC_1768|Compound:st044301|FD-Score:7.54|P-value:5.06E-14 ID:SGTC_1773|Compound:st048542|FD-Score:-3.54|P-value:2.56E-4 ID:SGTC_1775|Compound:st081588|FD-Score:7.07|P-value:1.46E-12 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.47|P-value:2.97E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.68|P-value:1.87E-6 ID:SGTC_1956|Compound:st077085|FD-Score:4.20|P-value:1.62E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.63|P-value:1.84E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.74|P-value:1.18E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.78|P-value:1.03E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.01|P-value:3.65E-7 ID:SGTC_2481|Compound:5478948|FD-Score:-3.45|P-value:3.56E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-4.47|P-value:5.71E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-3.75|P-value:1.17E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.70|P-value:1.42E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-3.34|P-value:5.27E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-4.38|P-value:8.38E-6 ID:SGTC_3326|Compound:9140064|FD-Score:3.19|P-value:7.87E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.32|P-value:5.01E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.99|P-value:4.07E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.99|P-value:4.00E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.21|P-value:7.52E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.27|P-value:1.36E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.18|P-value:9.09E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:5.26|P-value:1.03E-7 ID:SGTC_553|Compound:k007-0256|FD-Score:3.33|P-value:4.86E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.88|P-value:6.27E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.85|P-value:6.90E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.14|P-value:9.30E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.58|P-value:2.00E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-6.37|P-value:1.81E-10 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.99|P-value:4.11E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.31|P-value:5.35E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-6.13|P-value:8.19E-10 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.42|P-value:3.92E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.84|P-value:8.08E-5 ID:SGTC_1768|Compound:st044301|FD-Score:7.54|P-value:5.06E-14 ID:SGTC_1773|Compound:st048542|FD-Score:-3.54|P-value:2.56E-4 ID:SGTC_1775|Compound:st081588|FD-Score:7.07|P-value:1.46E-12 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.47|P-value:2.97E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.68|P-value:1.87E-6 ID:SGTC_1956|Compound:st077085|FD-Score:4.20|P-value:1.62E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.63|P-value:1.84E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.74|P-value:1.18E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.78|P-value:1.03E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.01|P-value:3.65E-7 ID:SGTC_2481|Compound:5478948|FD-Score:-3.45|P-value:3.56E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-4.47|P-value:5.71E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-3.75|P-value:1.17E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.70|P-value:1.42E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-3.34|P-value:5.27E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-4.38|P-value:8.38E-6 ID:SGTC_3326|Compound:9140064|FD-Score:3.19|P-value:7.87E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.32|P-value:5.01E-4

Top fitness defect scores for YER055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1768 st044301 7.54 37.2 µM 5.06E-14 1 2.44E-14
2 SGTC_1775 st081588 7.07 35.2 µM 1.46E-12 60S ribosome export 4 7.71E-13
3 SGTC_544 k015-0020 5.26 52.4 µM 1.03E-7 2 7.34E-8
4 SGTC_2444 5485484 5.01 36.4 µM 3.65E-7 12 2.69E-7
5 SGTC_1211 1056-0033 4.99 32.3 µM 4.11E-7 3 3.03E-7
6 SGTC_1926 methyl fluorone black 4.68 53.6 µM 1.87E-6 DNA intercalators 42 1.43E-6
7 SGTC_1956 st077085 4.20 54.0 µM 1.62E-5 15 1.31E-5
8 SGTC_146 3448-8650 3.99 53.1 µM 4.00E-5 NEO1-PIK1 133 3.32E-5
9 SGTC_131 0141-0277 3.99 33.9 µM 4.07E-5 37 3.37E-5
10 SGTC_845 0330-0138 3.88 4.5 µM 6.27E-5 20 5.26E-5
11 SGTC_847 0342-0274 3.85 5.5 µM 6.90E-5 20 5.80E-5
12 SGTC_1194 1488-0194 3.69 225.0 µM 1.30E-4 38 1.11E-4
13 SGTC_1197 1601-0112 3.63 267.0 µM 1.62E-4 28 1.39E-4
14 SGTC_1107 amlodipine 3.58 47.0 µM 2.00E-4 54 1.73E-4
15 SGTC_3013 9080133 3.51 71.4 µM 2.55E-4 39 2.22E-4
16 SGTC_2838 9002687 3.49 71.4 µM 2.79E-4 fatty acid desaturase (OLE1) 36 2.42E-4
17 SGTC_1879 gemcitabine 3.47 100.0 µM 2.97E-4 27 2.59E-4
18 SGTC_2067 5224629 3.36 34.1 µM 4.47E-4 43 3.94E-4
19 SGTC_553 k007-0256 3.33 45.7 µM 4.86E-4 heme biosynthesis & mitochondrial translocase 44 4.29E-4
20 SGTC_3340 9146634 3.32 11.1 µM 5.01E-4 30 4.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.16E-9 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.094 4.25E-8 YBR034C HMT1 hom Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.
0.093 6.57E-8 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.090 1.79E-7 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.086 5.29E-7 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.62E-7 YKR025W RPC37 het RNA polymerase III subunit C37
0.083 1.46E-6 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.083 1.52E-6 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.080 3.91E-6 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.079 4.47E-6 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.078 6.63E-6 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.075 1.50E-5 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.074 2.03E-5 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.072 3.00E-5 YOR336W KRE5 het Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
0.072 3.14E-5 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis