HIPHOP chemogenomics database

YER059W / PCL6

Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding

Zygosity: Homozygous strain

fixedexpanded
Profile for YER059W / PCL6

Click on Significant Values for Screen Details

Top fitness defect scores for YER059W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1718	roemerine	5.89	11.9 µM	6.36E-11	redox potentiating	16	1.89E-9
2	SGTC_1161	k007-0610	5.30	110.0 µM	3.60E-9	ERAD & cell cycle	72	5.64E-8
3	SGTC_2659	sanguinarine	5.21	24.2 µM	6.82E-9		11	9.67E-8
4	SGTC_2431	5490079	4.99	200.0 µM	2.61E-8		14	3.00E-7
5	SGTC_1126	isoteolin	4.83	1.0 µM	6.98E-8		13	6.87E-7
6	SGTC_568	1193-0097	4.74	7.5 µM	1.18E-7	ERAD & cell cycle	100	1.07E-6
7	SGTC_3060	1327-0027	4.31	12.5 µM	1.33E-6		31	8.23E-6
8	SGTC_354	2783-3500	4.30	4.9 µM	1.41E-6	cell wall	40	8.66E-6
9	SGTC_188	3229-0966	4.29	278.5 µM	1.47E-6		21	8.99E-6
10	SGTC_2322	7413319	4.26	38.2 µM	1.76E-6	ERAD & cell cycle	137	1.04E-5
11	SGTC_467	ro 31-8220	4.19	72.8 µM	2.49E-6	calcium & mitochondrial duress	65	1.40E-5
12	SGTC_1120	ficusin	4.04	1.8 µM	5.40E-6		24	2.70E-5
13	SGTC_3219	9131112	3.92	49.5 µM	9.78E-6	Golgi	35	4.45E-5
14	SGTC_2867	9039098	3.87	71.4 µM	1.22E-5	iron homeostasis	37	5.37E-5
15	SGTC_453	enantio-paf c16	3.86	10.0 µM	1.29E-5		151	5.61E-5
16	SGTC_2326	6164455	3.64	177.6 µM	3.68E-5	mitochondrial processes	34	1.37E-4
17	SGTC_699	0375-0592	3.64	111.0 µM	3.75E-5	iron homeostasis	29	1.39E-4
18	SGTC_1089	terbinafine	3.58	2.2 µM	4.88E-5		23	1.74E-4
19	SGTC_3188	9110789	3.56	49.5 µM	5.34E-5	iron homeostasis	35	1.87E-4
20	SGTC_2450	5739737	3.56	12.9 µM	5.39E-5		38	1.89E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.180	8.39E-26	YOL065C	INP54	hom	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.158	4.11E-20	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.149	5.32E-18	YDR435C	PPM1	hom	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.135	4.42E-15	YJR083C	ACF4	hom	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.132	1.57E-14	YDR199W_d	YDR199W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.131	2.86E-14	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.130	4.40E-14	YKR031C	SPO14	hom	Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.129	6.42E-14	YLR380W	CSR1	hom	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.126	2.32E-13	YIL030C	SSM4	hom	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.123	8.78E-13	YDL122W	UBP1	hom	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.118	5.74E-12	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.118	7.85E-12	YDR376W	ARH1	het	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.113	5.71E-11	YHR042W	NCP1	het	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.113	6.41E-11	YDL133W	SRF1	hom	Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.112	6.74E-11	YDL148C	NOP14	het	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA