YER059W / PCL6

Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding

Zygosity: Homozygous strain
fixedexpanded
Profile for YER059W / PCL6

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:-3.20|P-value:2.20E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.54|P-value:5.81E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:4.29|P-value:1.47E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.94|P-value:6.16E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-2.82|P-value:9.67E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:2.99|P-value:5.71E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.30|P-value:1.41E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.91|P-value:6.78E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.17|P-value:2.44E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.86|P-value:1.29E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.19|P-value:2.49E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.74|P-value:1.18E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.64|P-value:3.75E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:2.89|P-value:8.32E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.58|P-value:4.88E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.04|P-value:5.40E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.83|P-value:6.98E-8 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.30|P-value:3.60E-9 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.88|P-value:8.66E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:2.95|P-value:6.53E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.15|P-value:3.01E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.15|P-value:3.01E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:5.89|P-value:6.36E-11 ID:SGTC_1737|Compound:st035557|FD-Score:-2.86|P-value:8.15E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.13|P-value:2.90E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.12|P-value:3.02E-6 ID:SGTC_2057|Compound:5236571|FD-Score:3.13|P-value:3.31E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-5.67|P-value:2.46E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.71|P-value:2.27E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.24|P-value:2.14E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-2.99|P-value:4.94E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.49|P-value:4.22E-7 ID:SGTC_2322|Compound:7413319|FD-Score:4.26|P-value:1.76E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.64|P-value:3.68E-5 ID:SGTC_2413|Compound:inermin|FD-Score:2.94|P-value:6.88E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.99|P-value:2.61E-8 ID:SGTC_2450|Compound:5739737|FD-Score:3.56|P-value:5.39E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.41|P-value:1.03E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.85|P-value:8.72E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.60|P-value:3.97E-10 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.21|P-value:6.82E-9 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.10|P-value:3.21E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:2.93|P-value:7.22E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.87|P-value:1.22E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.19|P-value:2.55E-4 ID:SGTC_2949|Compound:9072542|FD-Score:2.88|P-value:8.60E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-5.75|P-value:1.41E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.31|P-value:1.33E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.02|P-value:4.97E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.35|P-value:1.35E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.56|P-value:5.34E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.92|P-value:9.78E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.61|P-value:3.71E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.60|P-value:3.82E-5 ID:SGTC_3273|Compound:9137859|FD-Score:-2.90|P-value:7.15E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-2.92|P-value:6.64E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.20|P-value:2.20E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.54|P-value:5.81E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:4.29|P-value:1.47E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.94|P-value:6.16E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-2.82|P-value:9.67E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:2.99|P-value:5.71E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.30|P-value:1.41E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.91|P-value:6.78E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.17|P-value:2.44E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.86|P-value:1.29E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.19|P-value:2.49E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.74|P-value:1.18E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.64|P-value:3.75E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:2.89|P-value:8.32E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.58|P-value:4.88E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.04|P-value:5.40E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.83|P-value:6.98E-8 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.30|P-value:3.60E-9 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.88|P-value:8.66E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:2.95|P-value:6.53E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.15|P-value:3.01E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.15|P-value:3.01E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:5.89|P-value:6.36E-11 ID:SGTC_1737|Compound:st035557|FD-Score:-2.86|P-value:8.15E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.13|P-value:2.90E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.12|P-value:3.02E-6 ID:SGTC_2057|Compound:5236571|FD-Score:3.13|P-value:3.31E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-5.67|P-value:2.46E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.71|P-value:2.27E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.24|P-value:2.14E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-2.99|P-value:4.94E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.49|P-value:4.22E-7 ID:SGTC_2322|Compound:7413319|FD-Score:4.26|P-value:1.76E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.64|P-value:3.68E-5 ID:SGTC_2413|Compound:inermin|FD-Score:2.94|P-value:6.88E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.99|P-value:2.61E-8 ID:SGTC_2450|Compound:5739737|FD-Score:3.56|P-value:5.39E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.41|P-value:1.03E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.85|P-value:8.72E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.60|P-value:3.97E-10 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.21|P-value:6.82E-9 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.10|P-value:3.21E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:2.93|P-value:7.22E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.87|P-value:1.22E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.19|P-value:2.55E-4 ID:SGTC_2949|Compound:9072542|FD-Score:2.88|P-value:8.60E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-5.75|P-value:1.41E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.31|P-value:1.33E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.02|P-value:4.97E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.35|P-value:1.35E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.56|P-value:5.34E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.92|P-value:9.78E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.61|P-value:3.71E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.60|P-value:3.82E-5 ID:SGTC_3273|Compound:9137859|FD-Score:-2.90|P-value:7.15E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-2.92|P-value:6.64E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.09|P-value:3.88E-4

Top fitness defect scores for YER059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 5.89 11.9 µM 6.36E-11 redox potentiating 16 1.89E-9
2 SGTC_1161 k007-0610 5.30 110.0 µM 3.60E-9 ERAD & cell cycle 72 5.64E-8
3 SGTC_2659 sanguinarine 5.21 24.2 µM 6.82E-9 11 9.67E-8
4 SGTC_2431 5490079 4.99 200.0 µM 2.61E-8 14 3.00E-7
5 SGTC_1126 isoteolin 4.83 1.0 µM 6.98E-8 13 6.87E-7
6 SGTC_568 1193-0097 4.74 7.5 µM 1.18E-7 ERAD & cell cycle 100 1.07E-6
7 SGTC_3060 1327-0027 4.31 12.5 µM 1.33E-6 31 8.23E-6
8 SGTC_354 2783-3500 4.30 4.9 µM 1.41E-6 cell wall 40 8.66E-6
9 SGTC_188 3229-0966 4.29 278.5 µM 1.47E-6 21 8.99E-6
10 SGTC_2322 7413319 4.26 38.2 µM 1.76E-6 ERAD & cell cycle 137 1.04E-5
11 SGTC_467 ro 31-8220 4.19 72.8 µM 2.49E-6 calcium & mitochondrial duress 65 1.40E-5
12 SGTC_1120 ficusin 4.04 1.8 µM 5.40E-6 24 2.70E-5
13 SGTC_3219 9131112 3.92 49.5 µM 9.78E-6 Golgi 35 4.45E-5
14 SGTC_2867 9039098 3.87 71.4 µM 1.22E-5 iron homeostasis 37 5.37E-5
15 SGTC_453 enantio-paf c16 3.86 10.0 µM 1.29E-5 151 5.61E-5
16 SGTC_2326 6164455 3.64 177.6 µM 3.68E-5 mitochondrial processes 34 1.37E-4
17 SGTC_699 0375-0592 3.64 111.0 µM 3.75E-5 iron homeostasis 29 1.39E-4
18 SGTC_1089 terbinafine 3.58 2.2 µM 4.88E-5 23 1.74E-4
19 SGTC_3188 9110789 3.56 49.5 µM 5.34E-5 iron homeostasis 35 1.87E-4
20 SGTC_2450 5739737 3.56 12.9 µM 5.39E-5 38 1.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 8.39E-26 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.158 4.11E-20 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.149 5.32E-18 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.135 4.42E-15 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.132 1.57E-14 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.131 2.86E-14 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.130 4.40E-14 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.129 6.42E-14 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.126 2.32E-13 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.123 8.78E-13 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.118 5.74E-12 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.118 7.85E-12 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.113 5.71E-11 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.113 6.41E-11 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.112 6.74E-11 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA