YER060W / FCY21

Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function

Zygosity: Homozygous strain
fixedexpanded
Profile for YER060W / FCY21

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-2.91|P-value:9.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.69|P-value:4.41E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.54|P-value:8.47E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.27|P-value:2.56E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.73|P-value:4.16E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.57|P-value:8.25E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:2.97|P-value:8.52E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.25|P-value:2.74E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.86|P-value:2.35E-5 ID:SGTC_444|Compound:curcumin|FD-Score:4.55|P-value:7.56E-7 ID:SGTC_493|Compound:zm226600|FD-Score:-3.18|P-value:3.54E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.03|P-value:6.87E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.15|P-value:5.85E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:6.27|P-value:1.66E-11 ID:SGTC_626|Compound:0214-0009|FD-Score:3.53|P-value:9.76E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.76|P-value:3.62E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.32|P-value:2.04E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.37|P-value:1.88E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.23|P-value:3.27E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.03|P-value:6.98E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.70|P-value:4.77E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.56|P-value:8.72E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.22|P-value:4.18E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.69|P-value:3.54E-7 ID:SGTC_1423|Compound:4048-0112|FD-Score:2.93|P-value:9.97E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.94|P-value:1.62E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-2.99|P-value:7.46E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.91|P-value:9.95E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.54|P-value:9.46E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.69|P-value:4.80E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.18|P-value:4.03E-4 ID:SGTC_2239|Compound:6685329|FD-Score:2.98|P-value:8.21E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.56|P-value:8.45E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-6.07|P-value:5.88E-11 ID:SGTC_2348|Compound:9022543|FD-Score:-3.24|P-value:2.83E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.36|P-value:1.77E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.24|P-value:3.09E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.16|P-value:5.60E-6 ID:SGTC_2960|Compound:9079389|FD-Score:3.63|P-value:6.41E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-4.08|P-value:7.40E-6 ID:SGTC_2965|Compound:9082772|FD-Score:5.08|P-value:3.97E-8 ID:SGTC_3218|Compound:9131285|FD-Score:2.95|P-value:9.40E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.88|P-value:1.27E-7 ID:SGTC_3302|Compound:9125395|FD-Score:-3.13|P-value:4.38E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-5.38|P-value:5.46E-9 ID:SGTC_3306|Compound:9127676|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_3334|Compound:9142812|FD-Score:2.97|P-value:8.64E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.91|P-value:9.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.69|P-value:4.41E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.54|P-value:8.47E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.27|P-value:2.56E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.73|P-value:4.16E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.57|P-value:8.25E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:2.97|P-value:8.52E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.25|P-value:2.74E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.86|P-value:2.35E-5 ID:SGTC_444|Compound:curcumin|FD-Score:4.55|P-value:7.56E-7 ID:SGTC_493|Compound:zm226600|FD-Score:-3.18|P-value:3.54E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.03|P-value:6.87E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.15|P-value:5.85E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:6.27|P-value:1.66E-11 ID:SGTC_626|Compound:0214-0009|FD-Score:3.53|P-value:9.76E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.76|P-value:3.62E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.32|P-value:2.04E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.37|P-value:1.88E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.23|P-value:3.27E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.03|P-value:6.98E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.70|P-value:4.77E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.56|P-value:8.72E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.22|P-value:4.18E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.69|P-value:3.54E-7 ID:SGTC_1423|Compound:4048-0112|FD-Score:2.93|P-value:9.97E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.94|P-value:1.62E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-2.99|P-value:7.46E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.91|P-value:9.95E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.54|P-value:9.46E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.69|P-value:4.80E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.18|P-value:4.03E-4 ID:SGTC_2239|Compound:6685329|FD-Score:2.98|P-value:8.21E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.56|P-value:8.45E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-6.07|P-value:5.88E-11 ID:SGTC_2348|Compound:9022543|FD-Score:-3.24|P-value:2.83E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.36|P-value:1.77E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.24|P-value:3.09E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.16|P-value:5.60E-6 ID:SGTC_2960|Compound:9079389|FD-Score:3.63|P-value:6.41E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-4.08|P-value:7.40E-6 ID:SGTC_2965|Compound:9082772|FD-Score:5.08|P-value:3.97E-8 ID:SGTC_3218|Compound:9131285|FD-Score:2.95|P-value:9.40E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.88|P-value:1.27E-7 ID:SGTC_3302|Compound:9125395|FD-Score:-3.13|P-value:4.38E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-5.38|P-value:5.46E-9 ID:SGTC_3306|Compound:9127676|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_3334|Compound:9142812|FD-Score:2.97|P-value:8.64E-4

Top fitness defect scores for YER060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_563 tetrahydrosecaminediol 6.27 614.0 µM 1.66E-11 amide catabolism 3 1.77E-10
2 SGTC_2965 9082772 5.08 38.6 µM 3.97E-8 mitochondrial response to ROS 18 1.88E-7
3 SGTC_3299 9121982 4.88 43.1 µM 1.27E-7 10 5.35E-7
4 SGTC_1338 1486-1223 4.69 76.0 µM 3.54E-7 7 1.34E-6
5 SGTC_444 curcumin 4.55 90.4 µM 7.56E-7 iron homeostasis 16 2.64E-6
6 SGTC_1254 0550-0035 4.22 264.0 µM 4.18E-6 13 1.23E-5
7 SGTC_2591 skatole 4.16 100.0 µM 5.60E-6 26 1.60E-5
8 SGTC_511 blebbistatin 4.15 171.0 µM 5.85E-6 DNA intercalators 18 1.66E-5
9 SGTC_1586 deoxycorticosterone acetate 3.94 53.7 µM 1.62E-5 9 4.14E-5
10 SGTC_407 eburnamonine 3.86 100.0 µM 2.35E-5 14 5.79E-5
11 SGTC_636 0kpi-0074 3.76 126.0 µM 3.62E-5 25 8.53E-5
12 SGTC_178 4092-0806 3.73 87.5 µM 4.16E-5 ergosterol depletion effects on membrane 109 9.69E-5
13 SGTC_1053 3366-3204 3.70 134.0 µM 4.77E-5 cell wall 44 1.10E-4
14 SGTC_1712 st032288 3.69 53.4 µM 4.80E-5 calcium & mitochondrial duress 206 1.10E-4
15 SGTC_2960 9079389 3.63 6.0 µM 6.41E-5 40 1.43E-4
16 SGTC_216 k038-0035 3.57 28.4 µM 8.25E-5 ubiquinone biosynthesis & proteasome 59 1.79E-4
17 SGTC_2284 7945075 3.56 39.2 µM 8.45E-5 mitochondrial processes 38 1.83E-4
18 SGTC_1089 terbinafine 3.56 2.2 µM 8.72E-5 25 1.88E-4
19 SGTC_1630 st005209 3.54 31.3 µM 9.46E-5 37 2.03E-4
20 SGTC_626 0214-0009 3.53 33.0 µM 9.76E-5 copper-dependent oxidative stress 32 2.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.98E-12 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.118 7.73E-12 YDR156W RPA14 hom RNA polymerase I subunit A14
0.115 2.38E-11 YBR145W ADH5 hom Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication
0.104 1.40E-9 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.096 2.69E-8 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.094 5.42E-8 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.087 4.32E-7 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.086 5.38E-7 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.084 1.16E-6 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.083 1.52E-6 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.079 4.64E-6 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.076 9.63E-6 YDR356W SPC110 het Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
0.076 1.00E-5 YGL227W VID30 hom Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
0.075 1.26E-5 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.075 1.28E-5 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p