YER062C / HOR2

Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER062C / HOR2

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.27|P-value:2.24E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.90|P-value:1.14E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:-2.94|P-value:8.21E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.86|P-value:1.39E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.30|P-value:1.70E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.61|P-value:5.37E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:-2.89|P-value:0.00100 ID:SGTC_883|Compound:0850-0245|FD-Score:2.88|P-value:8.61E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.42|P-value:9.94E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.68|P-value:3.99E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.65|P-value:3.63E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.92|P-value:7.00E-11 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.41|P-value:1.27E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:2.98|P-value:6.03E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.55|P-value:4.07E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:-2.92|P-value:8.90E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.23|P-value:2.80E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.19|P-value:2.57E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.12|P-value:3.39E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-2.96|P-value:7.49E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.51|P-value:6.81E-5 ID:SGTC_2398|Compound:5228213|FD-Score:4.41|P-value:8.64E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-2.95|P-value:7.90E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.01|P-value:6.43E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.16|P-value:2.92E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.87|P-value:8.92E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.27|P-value:2.24E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.90|P-value:1.14E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:-2.94|P-value:8.21E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.86|P-value:1.39E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.30|P-value:1.70E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.61|P-value:5.37E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:-2.89|P-value:0.00100 ID:SGTC_883|Compound:0850-0245|FD-Score:2.88|P-value:8.61E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.42|P-value:9.94E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.68|P-value:3.99E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.65|P-value:3.63E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.92|P-value:7.00E-11 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.41|P-value:1.27E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:2.98|P-value:6.03E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.55|P-value:4.07E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:-2.92|P-value:8.90E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.23|P-value:2.80E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.19|P-value:2.57E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.12|P-value:3.39E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-2.96|P-value:7.49E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.51|P-value:6.81E-5 ID:SGTC_2398|Compound:5228213|FD-Score:4.41|P-value:8.64E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-2.95|P-value:7.90E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.01|P-value:6.43E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.16|P-value:2.92E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.87|P-value:8.92E-4

Top fitness defect scores for YER062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1176 0848-0131 5.92 83.3 µM 7.00E-11 Golgi 2 1.60E-9
2 SGTC_1278 0874-0585 4.55 172.0 µM 4.07E-7 8 2.74E-6
3 SGTC_2398 5228213 4.41 48.8 µM 8.64E-7 iron homeostasis 25 5.22E-6
4 SGTC_87 0100-0052 3.90 35.5 µM 1.14E-5 110 4.80E-5
5 SGTC_102 gallobenzophenone 3.86 83.6 µM 1.39E-5 redox potentiating 46 5.70E-5
6 SGTC_1169 aniline yellow 3.65 25.8 µM 3.63E-5 18 1.30E-4
7 SGTC_1878 temozolomide 3.51 1.0 mM 6.81E-5 14 2.23E-4
8 SGTC_889 0919-1524 3.42 82.7 µM 9.94E-5 30 3.09E-4
9 SGTC_542 3381-0244 3.30 89.3 µM 1.70E-4 69 4.91E-4
10 SGTC_1449 4112-4002 3.19 201.0 µM 2.57E-4 RPP1 & pyrimidine depletion 36 7.00E-4
11 SGTC_2935 9038016 3.16 30.0 µM 2.92E-4 51 7.82E-4
12 SGTC_1701 st028638 3.12 40.4 µM 3.39E-4 42 8.90E-4
13 SGTC_1274 0865-0114 2.98 173.0 µM 6.03E-4 58 0.00146
14 SGTC_883 0850-0245 2.88 24.6 µM 8.61E-4 cell wall 81 0.00198
15 SGTC_3342 9147791 2.87 14.5 µM 8.92E-4 60 0.00205
16 SGTC_69 0096-0274 2.84 206.7 µM 0.00101 mitochondrial processes 122 0.00228
17 SGTC_1567 st069303 2.72 68.4 µM 0.00152 mitochondrial processes 97 0.00324
18 SGTC_2524 avocatin b 2.68 10.6 µM 0.00178 74 0.00371
19 SGTC_1631 benzylvanillin 2.66 81.9 µM 0.00187 Golgi 110 0.00388
20 SGTC_1795 st049545 2.65 62.3 µM 0.00195 TSC3-RPN4 71 0.00401

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 5.12E-34 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.155 1.79E-19 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.141 1.83E-16 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.139 5.26E-16 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.139 6.56E-16 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.132 1.42E-14 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.131 2.24E-14 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.128 9.76E-14 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.122 1.26E-12 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.118 8.30E-12 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.118 8.52E-12 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.116 1.73E-11 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.115 2.15E-11 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.112 7.17E-11 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.110 1.81E-10 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds