YER066W_p / RRT13

Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription

Zygosity: Homozygous strain
fixedexpanded
Profile for YER066W / RRT13

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.24|P-value:8.36E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:2.83|P-value:4.88E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.91|P-value:2.69E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.26|P-value:7.52E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:2.67|P-value:9.52E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:2.89|P-value:3.83E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.49|P-value:2.51E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.70|P-value:8.40E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:2.76|P-value:6.50E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.57|P-value:1.59E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.13|P-value:1.39E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-2.86|P-value:4.35E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.75|P-value:6.90E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.67|P-value:9.59E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-2.75|P-value:6.88E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.95|P-value:2.90E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.37|P-value:4.38E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.69|P-value:8.69E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.06|P-value:2.01E-9 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.36|P-value:4.64E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.46|P-value:1.04E-7 ID:SGTC_1678|Compound:st019265|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.17|P-value:6.16E-7 ID:SGTC_1822|Compound:st052468|FD-Score:-3.08|P-value:1.66E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.69|P-value:8.70E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.79|P-value:5.90E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.83|P-value:4.08E-6 ID:SGTC_1976|Compound:st070609|FD-Score:2.88|P-value:3.97E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-2.69|P-value:8.59E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.66|P-value:2.92E-8 ID:SGTC_2330|Compound:7979373|FD-Score:-3.21|P-value:9.16E-5 ID:SGTC_2354|Compound:9060492|FD-Score:4.12|P-value:8.11E-7 ID:SGTC_2403|Compound:6032726|FD-Score:-2.65|P-value:9.91E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.69|P-value:8.77E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-2.94|P-value:3.05E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.67|P-value:9.56E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-22.90|P-value:5.75E-157 ID:SGTC_2694|Compound:st077685|FD-Score:-2.77|P-value:6.29E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.68|P-value:9.33E-6 ID:SGTC_2948|Compound:9070189|FD-Score:5.36|P-value:2.19E-10 ID:SGTC_2949|Compound:9072542|FD-Score:2.74|P-value:7.25E-4 ID:SGTC_2950|Compound:9072895|FD-Score:2.67|P-value:9.50E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.11|P-value:1.43E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.45|P-value:2.98E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.02|P-value:2.16E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-5.35|P-value:2.37E-10 ID:SGTC_3286|Compound:9117135|FD-Score:-8.17|P-value:8.85E-22 ID:SGTC_3289|Compound:9119912|FD-Score:2.79|P-value:5.82E-4 ID:SGTC_3298|Compound:9116858|FD-Score:4.13|P-value:7.61E-7 ID:SGTC_3310|Compound:9130229|FD-Score:4.00|P-value:1.67E-6 ID:SGTC_3340|Compound:9146634|FD-Score:4.08|P-value:1.02E-6 ID:SGTC_3355|Compound:9151058|FD-Score:-3.16|P-value:1.15E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.24|P-value:8.36E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:2.83|P-value:4.88E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.91|P-value:2.69E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.26|P-value:7.52E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:2.67|P-value:9.52E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:2.89|P-value:3.83E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.49|P-value:2.51E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.70|P-value:8.40E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:2.76|P-value:6.50E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.57|P-value:1.59E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.13|P-value:1.39E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-2.86|P-value:4.35E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.75|P-value:6.90E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.67|P-value:9.59E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-2.75|P-value:6.88E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.95|P-value:2.90E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.37|P-value:4.38E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.69|P-value:8.69E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.06|P-value:2.01E-9 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.36|P-value:4.64E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.46|P-value:1.04E-7 ID:SGTC_1678|Compound:st019265|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.17|P-value:6.16E-7 ID:SGTC_1822|Compound:st052468|FD-Score:-3.08|P-value:1.66E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.69|P-value:8.70E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.79|P-value:5.90E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.83|P-value:4.08E-6 ID:SGTC_1976|Compound:st070609|FD-Score:2.88|P-value:3.97E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-2.69|P-value:8.59E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.66|P-value:2.92E-8 ID:SGTC_2330|Compound:7979373|FD-Score:-3.21|P-value:9.16E-5 ID:SGTC_2354|Compound:9060492|FD-Score:4.12|P-value:8.11E-7 ID:SGTC_2403|Compound:6032726|FD-Score:-2.65|P-value:9.91E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.69|P-value:8.77E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-2.94|P-value:3.05E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.67|P-value:9.56E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-22.90|P-value:5.75E-157 ID:SGTC_2694|Compound:st077685|FD-Score:-2.77|P-value:6.29E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.68|P-value:9.33E-6 ID:SGTC_2948|Compound:9070189|FD-Score:5.36|P-value:2.19E-10 ID:SGTC_2949|Compound:9072542|FD-Score:2.74|P-value:7.25E-4 ID:SGTC_2950|Compound:9072895|FD-Score:2.67|P-value:9.50E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.11|P-value:1.43E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.45|P-value:2.98E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.02|P-value:2.16E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-5.35|P-value:2.37E-10 ID:SGTC_3286|Compound:9117135|FD-Score:-8.17|P-value:8.85E-22 ID:SGTC_3289|Compound:9119912|FD-Score:2.79|P-value:5.82E-4 ID:SGTC_3298|Compound:9116858|FD-Score:4.13|P-value:7.61E-7 ID:SGTC_3310|Compound:9130229|FD-Score:4.00|P-value:1.67E-6 ID:SGTC_3340|Compound:9146634|FD-Score:4.08|P-value:1.02E-6 ID:SGTC_3355|Compound:9151058|FD-Score:-3.16|P-value:1.15E-4

Top fitness defect scores for YER066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2948 9070189 5.36 9.4 µM 2.19E-10 plasma membrane duress 27 4.11E-8
2 SGTC_1456 k015-0012 5.06 13.0 µM 2.01E-9 11 2.14E-7
3 SGTC_2282 7944268 4.66 200.0 µM 2.92E-8 RPP1 & pyrimidine depletion 16 1.57E-6
4 SGTC_1570 verbenone 4.46 133.0 µM 1.04E-7 9 4.06E-6
5 SGTC_1731 st035964 4.17 63.0 µM 6.16E-7 24 1.53E-5
6 SGTC_3298 9116858 4.13 71.4 µM 7.61E-7 6 1.79E-5
7 SGTC_2354 9060492 4.12 162.0 µM 8.11E-7 12 1.88E-5
8 SGTC_3340 9146634 4.08 11.1 µM 1.02E-6 10 2.23E-5
9 SGTC_3310 9130229 4.00 44.1 µM 1.67E-6 Golgi 26 3.23E-5
10 SGTC_114 0364-0001 3.91 490.3 µM 2.69E-6 51 4.61E-5
11 SGTC_1923 st058458 3.83 19.1 µM 4.08E-6 36 6.30E-5
12 SGTC_720 r052-1644 3.70 49.9 µM 8.40E-6 TSC3-RPN4 33 1.08E-4
13 SGTC_2815 7968870 3.68 71.4 µM 9.33E-6 30 1.17E-4
14 SGTC_679 0422-0091 3.49 41.4 µM 2.51E-5 Golgi 51 2.46E-4
15 SGTC_3106 9121286 3.45 49.5 µM 2.98E-5 28 2.79E-4
16 SGTC_1283 0922-0125 3.37 16.4 µM 4.38E-5 43 3.74E-4
17 SGTC_143 4032-1194 3.26 15.7 µM 7.52E-5 107 5.60E-4
18 SGTC_43 0570-0105 3.24 72.5 µM 8.36E-5 ERG2 157 6.07E-4
19 SGTC_1003 4049-0218 3.13 100.0 µM 1.39E-4 56 8.89E-4
20 SGTC_517 1365-0151 3.08 113.0 µM 1.73E-4 68 0.00105

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.469 5.02E-183 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.448 1.64E-165 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.396 2.09E-126 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.350 2.28E-97 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.335 1.55E-88 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.324 5.59E-83 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.322 8.74E-82 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.314 1.88E-77 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.305 1.93E-73 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.301 3.77E-71 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.298 5.28E-70 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.296 6.20E-69 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.270 3.51E-57 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.268 4.86E-56 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.255 7.38E-51 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C