YER067W / RGI1

Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER067W / RGI1

Click on Significant Values for Screen Details ID:SGTC_1035|Compound:k081-0041|FD-Score:3.09|P-value:3.17E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.16|P-value:2.79E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.92|P-value:6.21E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.11|P-value:3.57E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.11|P-value:3.61E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-2.99|P-value:5.75E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.05|P-value:3.68E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.42|P-value:9.56E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.48|P-value:5.94E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.21|P-value:1.94E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.90|P-value:6.70E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.36|P-value:7.50E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.73|P-value:1.38E-10 ID:SGTC_2304|Compound:7443016|FD-Score:-3.52|P-value:6.40E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.79|P-value:8.57E-8 ID:SGTC_2314|Compound:7727897|FD-Score:-3.25|P-value:2.00E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.41|P-value:5.58E-7 ID:SGTC_2585|Compound:alliin|FD-Score:3.67|P-value:2.53E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.68|P-value:1.65E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.30|P-value:1.60E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.45|P-value:6.72E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.88|P-value:1.18E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.33|P-value:8.58E-7 ID:SGTC_2949|Compound:9072542|FD-Score:3.37|P-value:9.60E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.80|P-value:1.36E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.15|P-value:3.02E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.05|P-value:4.47E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.26|P-value:1.52E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-5.59|P-value:4.97E-10 ID:SGTC_3195|Compound:9113082|FD-Score:2.98|P-value:4.85E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.46|P-value:6.57E-5 ID:SGTC_3257|Compound:9139206|FD-Score:-3.18|P-value:2.71E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.87|P-value:1.23E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.09|P-value:3.17E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.16|P-value:2.79E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.92|P-value:6.21E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.11|P-value:3.57E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.11|P-value:3.61E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-2.99|P-value:5.75E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.05|P-value:3.68E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.42|P-value:9.56E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.48|P-value:5.94E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.21|P-value:1.94E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.90|P-value:6.70E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.36|P-value:7.50E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.73|P-value:1.38E-10 ID:SGTC_2304|Compound:7443016|FD-Score:-3.52|P-value:6.40E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.79|P-value:8.57E-8 ID:SGTC_2314|Compound:7727897|FD-Score:-3.25|P-value:2.00E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.41|P-value:5.58E-7 ID:SGTC_2585|Compound:alliin|FD-Score:3.67|P-value:2.53E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.68|P-value:1.65E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.30|P-value:1.60E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.45|P-value:6.72E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.88|P-value:1.18E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.33|P-value:8.58E-7 ID:SGTC_2949|Compound:9072542|FD-Score:3.37|P-value:9.60E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.80|P-value:1.36E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.15|P-value:3.02E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.05|P-value:4.47E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.26|P-value:1.52E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-5.59|P-value:4.97E-10 ID:SGTC_3195|Compound:9113082|FD-Score:2.98|P-value:4.85E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.46|P-value:6.57E-5 ID:SGTC_3257|Compound:9139206|FD-Score:-3.18|P-value:2.71E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.87|P-value:1.23E-5

Top fitness defect scores for YER067W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2131 toluylene red 5.73 5.3 µM 1.38E-10 60S ribosome export 1 5.14E-9
2 SGTC_2397 5161689 4.41 200.0 µM 5.58E-7 20 5.12E-6
3 SGTC_2126 5251174 4.36 33.9 µM 7.50E-7 20 6.55E-6
4 SGTC_2837 9008476 4.33 45.5 µM 8.58E-7 22 7.33E-6
5 SGTC_2991 9074669 3.80 71.4 µM 1.36E-5 azole & statin 72 7.32E-5
6 SGTC_2585 alliin 3.67 100.0 µM 2.53E-5 36 1.23E-4
7 SGTC_1927 st060202 3.48 13.8 µM 5.94E-5 32 2.49E-4
8 SGTC_3232 9132874 3.46 49.5 µM 6.57E-5 RPP1 & pyrimidine depletion 30 2.71E-4
9 SGTC_2780 5215298 3.45 71.4 µM 6.72E-5 56 2.76E-4
10 SGTC_2949 9072542 3.37 2.2 µM 9.60E-5 TSC3-RPN4 63 3.72E-4
11 SGTC_3082 9117008 3.26 49.5 µM 1.52E-4 40 5.48E-4
12 SGTC_1937 st074714 3.21 47.2 µM 1.94E-4 66 6.69E-4
13 SGTC_1035 k081-0041 3.09 55.2 µM 3.17E-4 Golgi 57 0.00101
14 SGTC_1920 st075728 3.05 45.7 µM 3.68E-4 70 0.00114
15 SGTC_3195 9113082 2.98 49.5 µM 4.85E-4 47 0.00144
16 SGTC_1206 3978-0017 2.92 132.0 µM 6.21E-4 ERG2 79 0.00177
17 SGTC_2022 5136654 2.90 200.0 µM 6.70E-4 70 0.00188
18 SGTC_2827 7993847 2.71 71.4 µM 0.00136 83 0.00340
19 SGTC_1999 st074831 2.67 12.5 µM 0.00153 plasma membrane duress 109 0.00376
20 SGTC_1700 st030840 2.59 7.9 µM 0.00205 PDR1 92 0.00480

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.11E-31 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.188 5.99E-28 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.144 4.78E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.139 7.09E-16 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.133 8.63E-15 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.130 3.80E-14 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.129 5.39E-14 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.127 1.34E-13 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.123 8.42E-13 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.116 1.95E-11 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.115 1.99E-11 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.115 2.68E-11 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 4.22E-11 YBR033W_p EDS1_p hom Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication
0.113 5.72E-11 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.113 5.91E-11 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress