YER074W / RPS24A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER074W / RPS24A

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.46|P-value:3.85E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.60|P-value:2.36E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.40|P-value:7.53E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.79|P-value:1.79E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:5.95|P-value:4.65E-9 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.59|P-value:4.00E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:5.25|P-value:2.03E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.58|P-value:4.03E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.30|P-value:2.79E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.69|P-value:2.84E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-5.09|P-value:8.55E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.38|P-value:2.06E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.48|P-value:3.60E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.30|P-value:6.60E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.33|P-value:5.94E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.69|P-value:2.75E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-4.56|P-value:9.46E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.77|P-value:1.27E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.02|P-value:6.17E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.47|P-value:3.73E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.00|P-value:6.62E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.00|P-value:5.25E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.55|P-value:2.81E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.23|P-value:2.08E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.03|P-value:4.62E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:5.90|P-value:6.31E-9 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.96|P-value:1.02E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.80|P-value:1.87E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-4.11|P-value:5.79E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.33|P-value:2.38E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.46|P-value:3.78E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.46|P-value:6.22E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.40|P-value:4.74E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.71|P-value:2.66E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-4.75|P-value:4.14E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.71|P-value:2.61E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-6.67|P-value:1.51E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.28|P-value:2.39E-19 ID:SGTC_1860|Compound:st056228|FD-Score:4.30|P-value:1.58E-5 ID:SGTC_1995|Compound:st072814|FD-Score:-3.50|P-value:5.41E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.86|P-value:8.97E-5 ID:SGTC_2248|Compound:tofa|FD-Score:4.72|P-value:2.48E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.86|P-value:1.28E-6 ID:SGTC_2302|Compound:7771753|FD-Score:4.77|P-value:1.97E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.05|P-value:4.38E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.85|P-value:9.17E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-3.34|P-value:9.01E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:16.00|P-value:2.14E-53 ID:SGTC_2416|Compound:tofa|FD-Score:3.41|P-value:4.53E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.35|P-value:5.57E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.26|P-value:7.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.01|P-value:8.62E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-5.02|P-value:1.17E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.58|P-value:8.39E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.36|P-value:8.61E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.10|P-value:4.13E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.66|P-value:3.28E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.52|P-value:5.05E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.87|P-value:8.72E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.35|P-value:8.89E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.73|P-value:2.42E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.77|P-value:1.27E-4 ID:SGTC_2948|Compound:9070189|FD-Score:10.40|P-value:8.01E-24 ID:SGTC_2951|Compound:9072950|FD-Score:-4.27|P-value:3.13E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.24|P-value:7.98E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.61|P-value:2.29E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.61|P-value:2.30E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-4.70|P-value:5.09E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-3.76|P-value:2.17E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.24|P-value:1.98E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.20|P-value:9.06E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.46|P-value:3.85E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.60|P-value:2.36E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.40|P-value:7.53E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.79|P-value:1.79E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:5.95|P-value:4.65E-9 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.59|P-value:4.00E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:5.25|P-value:2.03E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.58|P-value:4.03E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.30|P-value:2.79E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.69|P-value:2.84E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-5.09|P-value:8.55E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.38|P-value:2.06E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.48|P-value:3.60E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.30|P-value:6.60E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.33|P-value:5.94E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.69|P-value:2.75E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-4.56|P-value:9.46E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.77|P-value:1.27E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.02|P-value:6.17E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.47|P-value:3.73E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.00|P-value:6.62E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.00|P-value:5.25E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.55|P-value:2.81E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.23|P-value:2.08E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.03|P-value:4.62E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:5.90|P-value:6.31E-9 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.96|P-value:1.02E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.80|P-value:1.87E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-4.11|P-value:5.79E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.33|P-value:2.38E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.46|P-value:3.78E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.46|P-value:6.22E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.40|P-value:4.74E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.71|P-value:2.66E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-4.75|P-value:4.14E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.71|P-value:2.61E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-6.67|P-value:1.51E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.28|P-value:2.39E-19 ID:SGTC_1860|Compound:st056228|FD-Score:4.30|P-value:1.58E-5 ID:SGTC_1995|Compound:st072814|FD-Score:-3.50|P-value:5.41E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.86|P-value:8.97E-5 ID:SGTC_2248|Compound:tofa|FD-Score:4.72|P-value:2.48E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.86|P-value:1.28E-6 ID:SGTC_2302|Compound:7771753|FD-Score:4.77|P-value:1.97E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.05|P-value:4.38E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.85|P-value:9.17E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-3.34|P-value:9.01E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:16.00|P-value:2.14E-53 ID:SGTC_2416|Compound:tofa|FD-Score:3.41|P-value:4.53E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.35|P-value:5.57E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.26|P-value:7.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.01|P-value:8.62E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-5.02|P-value:1.17E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.58|P-value:8.39E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.36|P-value:8.61E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.10|P-value:4.13E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.66|P-value:3.28E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.52|P-value:5.05E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.87|P-value:8.72E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.35|P-value:8.89E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.73|P-value:2.42E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.77|P-value:1.27E-4 ID:SGTC_2948|Compound:9070189|FD-Score:10.40|P-value:8.01E-24 ID:SGTC_2951|Compound:9072950|FD-Score:-4.27|P-value:3.13E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.24|P-value:7.98E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.61|P-value:2.29E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.61|P-value:2.30E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-4.70|P-value:5.09E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-3.76|P-value:2.17E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.24|P-value:1.98E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.20|P-value:9.06E-4

Top fitness defect scores for YER074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 16.00 3.5 µM 2.14E-53 4 4.71E-58
2 SGTC_2948 9070189 10.40 9.4 µM 8.01E-24 plasma membrane duress 12 1.06E-25
3 SGTC_1844 rapamycin 9.28 4.0 nM 2.39E-19 44 8.13E-21
4 SGTC_176 1486-1328 5.95 72.8 µM 4.65E-9 21 1.30E-9
5 SGTC_1424 4048-1941 5.90 275.0 µM 6.31E-9 5 1.81E-9
6 SGTC_325 2810-4341 5.25 181.0 µM 2.03E-7 amide catabolism 2 7.80E-8
7 SGTC_2628 lathosterol 5.10 100.0 µM 4.13E-7 11 1.69E-7
8 SGTC_1119 parthenolide 5.02 318.5 nM 6.17E-7 TSC3-RPN4 20 2.60E-7
9 SGTC_1127 asiatic acid 5.00 681.4 nM 6.62E-7 8 2.81E-7
10 SGTC_2293 7624732 4.86 200.0 µM 1.28E-6 9 5.76E-7
11 SGTC_114 0364-0001 4.79 490.3 µM 1.79E-6 20 8.24E-7
12 SGTC_2302 7771753 4.77 200.0 µM 1.97E-6 22 9.17E-7
13 SGTC_2248 tofa 4.72 1.1 µM 2.48E-6 sphingolipid biosynthesis & PDR1 30 1.17E-6
14 SGTC_1729 st035615 4.71 46.0 µM 2.66E-6 20 1.27E-6
15 SGTC_422 cantharidin 4.69 155.0 µM 2.84E-6 cell wall signaling 39 1.36E-6
16 SGTC_2679 rapamycin 4.66 1.0 nM 3.28E-6 106 1.59E-6
17 SGTC_1860 st056228 4.30 74.6 µM 1.58E-5 9 8.68E-6
18 SGTC_3210 9128157 4.24 49.5 µM 1.98E-5 41 1.11E-5
19 SGTC_1258 0671-0043 4.23 57.1 µM 2.08E-5 18 1.17E-5
20 SGTC_2303 7774051 4.05 200.0 µM 4.38E-5 17 2.61E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.318 2.71E-79 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.185 3.98E-27 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.168 1.37E-22 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.166 4.87E-22 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.152 9.52E-19 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.147 1.43E-17 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.143 7.03E-17 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.141 2.59E-16 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.137 1.29E-15 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.132 1.44E-14 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.128 9.88E-14 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.125 3.54E-13 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.123 8.61E-13 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.123 9.69E-13 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.120 2.68E-12 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)