YER075C / PTP3

Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YER075C / PTP3

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:2.95|P-value:6.01E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.91|P-value:6.89E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.08|P-value:3.91E-6 ID:SGTC_228|Compound:caffeine|FD-Score:2.92|P-value:6.91E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-2.94|P-value:6.22E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.54|P-value:5.10E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.45|P-value:5.29E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:2.84|P-value:9.24E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.25|P-value:4.08E-9 ID:SGTC_734|Compound:2023-0417|FD-Score:3.46|P-value:7.23E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-5.16|P-value:7.68E-9 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.11|P-value:3.20E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.02|P-value:4.63E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.34|P-value:1.22E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.90|P-value:7.35E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.98|P-value:5.41E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.94|P-value:6.37E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.00|P-value:4.98E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.51|P-value:6.00E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-2.92|P-value:6.69E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.94|P-value:7.92E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.11|P-value:3.23E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.43|P-value:8.37E-5 ID:SGTC_1917|Compound:st066507|FD-Score:2.84|P-value:9.37E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-2.89|P-value:7.60E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.14|P-value:2.81E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.20|P-value:2.22E-4 ID:SGTC_2239|Compound:6685329|FD-Score:5.46|P-value:1.09E-9 ID:SGTC_2271|Compound:7849410|FD-Score:4.10|P-value:3.39E-6 ID:SGTC_2473|Compound:5854593|FD-Score:3.32|P-value:1.37E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.13|P-value:3.00E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.00|P-value:5.87E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.88|P-value:1.06E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.58|P-value:4.25E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.05|P-value:4.51E-6 ID:SGTC_2867|Compound:9039098|FD-Score:-2.84|P-value:9.26E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.63|P-value:3.50E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.75|P-value:1.93E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.04|P-value:4.31E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.06|P-value:3.91E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.06|P-value:3.95E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.24|P-value:1.90E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-4.07|P-value:3.95E-6 ID:SGTC_3298|Compound:9116858|FD-Score:3.46|P-value:7.24E-5 ID:SGTC_3300|Compound:9124615|FD-Score:2.97|P-value:5.52E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.08|P-value:3.58E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.95|P-value:6.01E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.91|P-value:6.89E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.08|P-value:3.91E-6 ID:SGTC_228|Compound:caffeine|FD-Score:2.92|P-value:6.91E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-2.94|P-value:6.22E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.54|P-value:5.10E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.45|P-value:5.29E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:2.84|P-value:9.24E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.25|P-value:4.08E-9 ID:SGTC_734|Compound:2023-0417|FD-Score:3.46|P-value:7.23E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-5.16|P-value:7.68E-9 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.11|P-value:3.20E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.02|P-value:4.63E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.34|P-value:1.22E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.90|P-value:7.35E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.98|P-value:5.41E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.94|P-value:6.37E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.00|P-value:4.98E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.51|P-value:6.00E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-2.92|P-value:6.69E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.94|P-value:7.92E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.11|P-value:3.23E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.43|P-value:8.37E-5 ID:SGTC_1917|Compound:st066507|FD-Score:2.84|P-value:9.37E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-2.89|P-value:7.60E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.14|P-value:2.81E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.20|P-value:2.22E-4 ID:SGTC_2239|Compound:6685329|FD-Score:5.46|P-value:1.09E-9 ID:SGTC_2271|Compound:7849410|FD-Score:4.10|P-value:3.39E-6 ID:SGTC_2473|Compound:5854593|FD-Score:3.32|P-value:1.37E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.13|P-value:3.00E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.00|P-value:5.87E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.88|P-value:1.06E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.58|P-value:4.25E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.05|P-value:4.51E-6 ID:SGTC_2867|Compound:9039098|FD-Score:-2.84|P-value:9.26E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.63|P-value:3.50E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.75|P-value:1.93E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.04|P-value:4.31E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.06|P-value:3.91E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.06|P-value:3.95E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.24|P-value:1.90E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-4.07|P-value:3.95E-6 ID:SGTC_3298|Compound:9116858|FD-Score:3.46|P-value:7.24E-5 ID:SGTC_3300|Compound:9124615|FD-Score:2.97|P-value:5.52E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.08|P-value:3.58E-4

Top fitness defect scores for YER075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2239 6685329 5.46 187.6 µM 1.09E-9 5 2.44E-8
2 SGTC_475 α-linolenic acid 4.45 10.0 µM 5.29E-7 excess fatty acid 15 4.30E-6
3 SGTC_2271 7849410 4.10 118.6 µM 3.39E-6 12 2.04E-5
4 SGTC_171 k064-0041 4.08 9.7 µM 3.91E-6 heme requiring 25 2.30E-5
5 SGTC_2787 5284540 4.05 71.4 µM 4.51E-6 21 2.59E-5
6 SGTC_2627 acetyl isogambogic acid 4.00 100.0 µM 5.87E-6 TSC3-RPN4 39 3.23E-5
7 SGTC_1734 st037168 3.94 69.4 µM 7.92E-6 23 4.15E-5
8 SGTC_2690 usnic acid 3.88 100.0 µM 1.06E-5 28 5.31E-5
9 SGTC_3156 9099931 3.75 49.5 µM 1.93E-5 12 8.75E-5
10 SGTC_3155 9099265 3.63 49.5 µM 3.50E-5 34 1.44E-4
11 SGTC_2781 5567276 3.58 71.4 µM 4.25E-5 66 1.70E-4
12 SGTC_403 arphamenine a 3.54 50.0 µM 5.10E-5 60S ribosome export 24 1.98E-4
13 SGTC_1728 st035614 3.51 33.8 µM 6.00E-5 75 2.27E-4
14 SGTC_734 2023-0417 3.46 80.0 µM 7.23E-5 ergosterol biosynthesis 31 2.65E-4
15 SGTC_3298 9116858 3.46 71.4 µM 7.24E-5 24 2.66E-4
16 SGTC_1736 st036774 3.43 51.0 µM 8.37E-5 55 3.00E-4
17 SGTC_2473 5854593 3.32 8.9 µM 1.37E-4 27 4.53E-4
18 SGTC_1214 0358-0031 3.27 63.7 µM 1.68E-4 39 5.38E-4
19 SGTC_3283 9109332 3.24 35.8 µM 1.90E-4 DNA intercalators 29 5.96E-4
20 SGTC_1735 st034310 3.11 56.8 µM 3.23E-4 Golgi 61 9.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.45E-18 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.112 7.18E-11 YBR079C RPG1 het eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
0.098 1.43E-8 YJL104W PAM16 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
0.093 6.47E-8 YDR496C PUF6 hom Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
0.093 7.76E-8 YNL173C MDG1 hom Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
0.090 1.95E-7 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.089 2.47E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.086 5.62E-7 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.084 9.76E-7 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.084 1.10E-6 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.081 2.40E-6 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.080 3.16E-6 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.079 4.63E-6 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.078 6.53E-6 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.075 1.24E-5 YPL152W-A_p YPL152W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching