YER076C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YER076C / YER076C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.66|P-value:9.00E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.78|P-value:5.53E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-4.64|P-value:9.90E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:3.48|P-value:1.83E-4 ID:SGTC_493|Compound:zm226600|FD-Score:5.53|P-value:7.94E-9 ID:SGTC_516|Compound:3992-2719|FD-Score:-6.04|P-value:3.07E-10 ID:SGTC_632|Compound:0781-2353|FD-Score:3.23|P-value:4.77E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.98|P-value:2.34E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.81|P-value:4.85E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.42|P-value:1.48E-8 ID:SGTC_1087|Compound:pterostilbene|FD-Score:6.56|P-value:9.65E-12 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.28|P-value:4.02E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.93|P-value:2.93E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.09|P-value:7.97E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.13|P-value:6.75E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.13|P-value:6.71E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.85|P-value:4.13E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.77|P-value:5.84E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.04|P-value:9.29E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.69|P-value:7.93E-7 ID:SGTC_2173|Compound:5763948|FD-Score:-3.28|P-value:3.87E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.74|P-value:6.60E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.86|P-value:3.97E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.15|P-value:6.29E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.63|P-value:1.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.12|P-value:6.98E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.98|P-value:2.32E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.81|P-value:4.95E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.63|P-value:1.11E-6 ID:SGTC_2958|Compound:9077254|FD-Score:-3.02|P-value:9.89E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.62|P-value:1.14E-6 ID:SGTC_3038|Compound:9091290|FD-Score:3.15|P-value:6.46E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.09|P-value:7.75E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.43|P-value:2.25E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.14|P-value:6.49E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.77|P-value:5.67E-5 ID:SGTC_3267|Compound:9137951|FD-Score:3.03|P-value:9.70E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.66|P-value:9.00E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.78|P-value:5.53E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-4.64|P-value:9.90E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:3.48|P-value:1.83E-4 ID:SGTC_493|Compound:zm226600|FD-Score:5.53|P-value:7.94E-9 ID:SGTC_516|Compound:3992-2719|FD-Score:-6.04|P-value:3.07E-10 ID:SGTC_632|Compound:0781-2353|FD-Score:3.23|P-value:4.77E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.98|P-value:2.34E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.81|P-value:4.85E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.42|P-value:1.48E-8 ID:SGTC_1087|Compound:pterostilbene|FD-Score:6.56|P-value:9.65E-12 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.28|P-value:4.02E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.93|P-value:2.93E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.09|P-value:7.97E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.13|P-value:6.75E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.13|P-value:6.71E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.85|P-value:4.13E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.77|P-value:5.84E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.04|P-value:9.29E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.69|P-value:7.93E-7 ID:SGTC_2173|Compound:5763948|FD-Score:-3.28|P-value:3.87E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.74|P-value:6.60E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.86|P-value:3.97E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.15|P-value:6.29E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.63|P-value:1.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.12|P-value:6.98E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.98|P-value:2.32E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.81|P-value:4.95E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.63|P-value:1.11E-6 ID:SGTC_2958|Compound:9077254|FD-Score:-3.02|P-value:9.89E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.62|P-value:1.14E-6 ID:SGTC_3038|Compound:9091290|FD-Score:3.15|P-value:6.46E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.09|P-value:7.75E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.43|P-value:2.25E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.14|P-value:6.49E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.77|P-value:5.67E-5 ID:SGTC_3267|Compound:9137951|FD-Score:3.03|P-value:9.70E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.63|P-value:1.01E-4

Top fitness defect scores for YER076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1087 pterostilbene 6.56 9.1 µM 9.65E-12 3 2.68E-11
2 SGTC_493 zm226600 5.53 134.0 µM 7.94E-9 mitochondrial processes 3 1.64E-8
3 SGTC_1077 5-fluorocytosine 5.42 377.0 nM 1.48E-8 exosome 4 2.98E-8
4 SGTC_1992 st073643 4.69 23.3 µM 7.93E-7 mitochondrial processes 5 1.34E-6
5 SGTC_2952 9073731 4.63 13.8 µM 1.11E-6 tubulin folding & SWR complex 19 1.85E-6
6 SGTC_2974 9094440 4.62 9.7 µM 1.14E-6 ergosterol biosynthesis 33 1.91E-6
7 SGTC_783 0848-0141 3.98 92.7 µM 2.34E-5 RSC & ERG11 12 3.43E-5
8 SGTC_1295 1013-0063 3.93 9.8 µM 2.93E-5 12 4.26E-5
9 SGTC_2431 5490079 3.86 200.0 µM 3.97E-5 40 5.69E-5
10 SGTC_1888 azatryptophan 3.85 97.5 µM 4.13E-5 21 5.91E-5
11 SGTC_868 0527-0199 3.81 213.0 µM 4.85E-5 fatty acid desaturase (OLE1) 30 6.90E-5
12 SGTC_2942 9052777 3.81 62.2 µM 4.95E-5 37 7.04E-5
13 SGTC_212 3807-4682 3.78 38.8 µM 5.53E-5 tubulin folding & SWR complex 75 7.82E-5
14 SGTC_3228 9131799 3.77 49.5 µM 5.67E-5 amide catabolism 7 8.01E-5
15 SGTC_1906 st060206 3.77 94.7 µM 5.84E-5 22 8.24E-5
16 SGTC_2266 7929956 3.74 200.0 µM 6.60E-5 42 9.27E-5
17 SGTC_6 0844-0013 3.66 19.8 µM 9.00E-5 119 1.25E-4
18 SGTC_3309 9129340 3.63 25.8 µM 1.01E-4 22 1.40E-4
19 SGTC_2483 5729050 3.61 27.2 µM 1.13E-4 34 1.55E-4
20 SGTC_431 k089-0097 3.48 107.0 µM 1.83E-4 iron homeostasis 64 2.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 8.23E-19 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.04E-11 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.115 2.55E-11 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.108 2.99E-10 YMR012W CLU1 hom eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.106 7.76E-10 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.102 2.76E-9 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.099 8.95E-9 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.097 2.03E-8 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.096 2.21E-8 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.094 4.35E-8 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.093 7.65E-8 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.092 8.17E-8 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.092 8.72E-8 YDL144C YDL144C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress
0.090 1.84E-7 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.089 2.58E-7 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation