YER079W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YER079W / YER079W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.60|P-value:1.07E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.52|P-value:1.64E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-6.63|P-value:5.75E-12 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.08|P-value:8.34E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.49|P-value:1.61E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.22|P-value:4.60E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.17|P-value:5.56E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.06|P-value:8.86E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.32|P-value:3.48E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.67|P-value:7.60E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.40|P-value:3.02E-6 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.74|P-value:5.57E-7 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.06|P-value:8.06E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.27|P-value:3.84E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.04|P-value:8.71E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.16|P-value:5.60E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.31|P-value:2.37E-8 ID:SGTC_1931|Compound:st074438|FD-Score:4.56|P-value:1.33E-6 ID:SGTC_1932|Compound:st074806|FD-Score:4.46|P-value:2.25E-6 ID:SGTC_2054|Compound:5233173|FD-Score:4.95|P-value:1.75E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.48|P-value:1.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.88|P-value:7.48E-10 ID:SGTC_2172|Compound:5754775|FD-Score:-3.63|P-value:1.06E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.50|P-value:1.56E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.05|P-value:8.42E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:6.75|P-value:1.94E-12 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.69|P-value:8.06E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.60|P-value:1.11E-6 ID:SGTC_2780|Compound:5215298|FD-Score:-3.11|P-value:7.63E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.51|P-value:2.06E-6 ID:SGTC_2826|Compound:7992541|FD-Score:-3.33|P-value:3.42E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.21|P-value:4.73E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.08|P-value:7.65E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.24|P-value:4.26E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-4.64|P-value:1.05E-6 ID:SGTC_3200|Compound:9114385|FD-Score:7.01|P-value:2.96E-13 ID:SGTC_3217|Compound:9129673|FD-Score:-3.36|P-value:3.07E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.18|P-value:5.27E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.24|P-value:4.68E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.44|P-value:2.21E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.60|P-value:1.07E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.52|P-value:1.64E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-6.63|P-value:5.75E-12 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.08|P-value:8.34E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.49|P-value:1.61E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.22|P-value:4.60E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.17|P-value:5.56E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.06|P-value:8.86E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.32|P-value:3.48E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.67|P-value:7.60E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.40|P-value:3.02E-6 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.74|P-value:5.57E-7 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.06|P-value:8.06E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.27|P-value:3.84E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.04|P-value:8.71E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.16|P-value:5.60E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.31|P-value:2.37E-8 ID:SGTC_1931|Compound:st074438|FD-Score:4.56|P-value:1.33E-6 ID:SGTC_1932|Compound:st074806|FD-Score:4.46|P-value:2.25E-6 ID:SGTC_2054|Compound:5233173|FD-Score:4.95|P-value:1.75E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.48|P-value:1.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.88|P-value:7.48E-10 ID:SGTC_2172|Compound:5754775|FD-Score:-3.63|P-value:1.06E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.50|P-value:1.56E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.05|P-value:8.42E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:6.75|P-value:1.94E-12 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.69|P-value:8.06E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.60|P-value:1.11E-6 ID:SGTC_2780|Compound:5215298|FD-Score:-3.11|P-value:7.63E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.51|P-value:2.06E-6 ID:SGTC_2826|Compound:7992541|FD-Score:-3.33|P-value:3.42E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.21|P-value:4.73E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.08|P-value:7.65E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.24|P-value:4.26E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-4.64|P-value:1.05E-6 ID:SGTC_3200|Compound:9114385|FD-Score:7.01|P-value:2.96E-13 ID:SGTC_3217|Compound:9129673|FD-Score:-3.36|P-value:3.07E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.18|P-value:5.27E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.24|P-value:4.68E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.44|P-value:2.21E-4

Top fitness defect scores for YER079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3200 9114385 7.01 49.5 µM 2.96E-13 4 1.20E-12
2 SGTC_2764 methyldopa 6.75 94.7 µM 1.94E-12 4 7.14E-12
3 SGTC_2066 5222451 5.88 176.0 µM 7.48E-10 heme biosynthesis & mitochondrial translocase 9 2.05E-9
4 SGTC_1720 st037298 5.31 9.5 µM 2.37E-8 17 5.46E-8
5 SGTC_2054 5233173 4.95 129.0 µM 1.75E-7 mitochondrial response to ROS 29 3.64E-7
6 SGTC_1278 0874-0585 4.74 172.0 µM 5.57E-7 6 1.09E-6
7 SGTC_803 4488-1585 4.67 147.0 µM 7.60E-7 6 1.47E-6
8 SGTC_2777 climbazole 4.60 1.5 µM 1.11E-6 iron homeostasis 27 2.11E-6
9 SGTC_1931 st074438 4.56 57.1 µM 1.33E-6 9 2.51E-6
10 SGTC_1932 st074806 4.46 40.9 µM 2.25E-6 14 4.13E-6
11 SGTC_961 1252-1571 4.40 372.0 µM 3.02E-6 21 5.46E-6
12 SGTC_8 0354-0001 3.60 70.0 µM 1.07E-4 96 1.61E-4
13 SGTC_116 0155-0182 3.59 31.8 µM 1.08E-4 mitochondrial response to ROS 107 1.64E-4
14 SGTC_2808 7946468 3.55 45.5 µM 1.27E-4 36 1.91E-4
15 SGTC_2592 piperlongumine 3.50 83.3 µM 1.56E-4 TSC3-RPN4 59 2.32E-4
16 SGTC_152 4469-0003 3.49 551.2 µM 1.61E-4 37 2.39E-4
17 SGTC_2063 5246145 3.48 200.0 µM 1.68E-4 39 2.49E-4
18 SGTC_1567 st069303 3.27 68.4 µM 3.84E-4 mitochondrial processes 44 5.46E-4
19 SGTC_2991 9074669 3.24 71.4 µM 4.26E-4 azole & statin 103 6.01E-4
20 SGTC_285 1486-1325 3.22 46.0 µM 4.60E-4 40 6.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.50E-11 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.108 4.29E-10 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.106 7.74E-10 YGR181W TIM13 hom Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.099 9.02E-9 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.098 1.33E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.096 2.41E-8 YDR151C CTH1 hom Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
0.091 1.16E-7 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.091 1.35E-7 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.089 2.15E-7 YLR208W SEC13 het Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
0.088 3.06E-7 YBR097W VPS15 hom Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.087 5.01E-7 YGL226W MTC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
0.086 6.24E-7 YGR133W PEX4 hom Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
0.085 8.99E-7 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.080 3.21E-6 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.079 4.26E-6 YJL126W NIT2 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member