YER082C / UTP7

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER082C / UTP7

Click on Significant Values for Screen Details ID:SGTC_610|Compound:4215-0184|FD-Score:-3.75|P-value:1.93E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.49|P-value:4.75E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-4.08|P-value:5.76E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.44|P-value:5.66E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.41|P-value:1.50E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.27|P-value:9.91E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.56|P-value:3.78E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.84|P-value:1.41E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.92|P-value:1.07E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.19|P-value:3.67E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.69|P-value:2.41E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-5.48|P-value:1.07E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.31|P-value:8.63E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-4.75|P-value:3.57E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.74|P-value:2.01E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.27|P-value:9.92E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.30|P-value:9.16E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.55|P-value:3.98E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.37|P-value:7.09E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.41|P-value:6.40E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.44|P-value:5.68E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.75|P-value:1.93E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.49|P-value:4.75E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-4.08|P-value:5.76E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.44|P-value:5.66E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.41|P-value:1.50E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.27|P-value:9.91E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.56|P-value:3.78E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.84|P-value:1.41E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.92|P-value:1.07E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.19|P-value:3.67E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.69|P-value:2.41E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-5.48|P-value:1.07E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.31|P-value:8.63E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-4.75|P-value:3.57E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.74|P-value:2.01E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.27|P-value:9.92E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.30|P-value:9.16E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.55|P-value:3.98E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.37|P-value:7.09E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.41|P-value:6.40E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.44|P-value:5.68E-4

Top fitness defect scores for YER082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1321 1326-2144 4.41 215.0 µM 1.50E-5 1 5.08E-6 0.42
2 SGTC_1144 3486-0183 3.73 12.5 µM 2.07E-4 6 9.41E-5 0.09
3 SGTC_909 3448-9333 3.49 149.0 µM 4.75E-4 3 2.37E-4 0.05
4 SGTC_3301 9125354 3.44 19.8 µM 5.68E-4 3 2.89E-4 0.14
5 SGTC_3008 9078912 3.41 71.4 µM 6.40E-4 5 3.31E-4 0.12
6 SGTC_1575 cyproterone acetate 3.31 48.0 µM 8.63E-4 14 4.61E-4 0.02
7 SGTC_1682 st012968 3.26 530.0 nM 0.00101 10 5.50E-4 0.08
8 SGTC_2615 purpurogallin-4-carboxylic acid 3.08 100.0 µM 0.00181 redox potentiating 22 0.00105 0.10
9 SGTC_999 4022-0066 2.94 22.7 µM 0.00275 Golgi 27 0.00167 0.24
10 SGTC_1564 D-Arginine 2.93 115.0 µM 0.00277 20 0.00168 0.05
11 SGTC_2601 securinine 2.92 100.0 µM 0.00289 37 0.00176 0.03
12 SGTC_429 1112-0049 2.92 25.5 µM 0.00290 DNA damage response 21 0.00177 0.01
13 SGTC_1163 k060-0048 2.91 49.9 µM 0.00293 9 0.00179 0.02
14 SGTC_1819 st053448 2.90 58.6 µM 0.00303 amide catabolism 15 0.00186 0.01
15 SGTC_430 0958-0115 2.88 16.4 µM 0.00325 26 0.00201 0.01
16 SGTC_304 1310-0298 2.87 97.0 µM 0.00334 cell wall 15 0.00207 0.07
17 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 2.86 54.9 µM 0.00339 redox potentiating 17 0.00210 0.04
18 SGTC_300 r073-0011 2.86 5.0 µM 0.00341 11 0.00211 0.10
19 SGTC_2234 tolnaftate 2.85 200.0 µM 0.00354 2 0.00221 0.37
20 SGTC_1728 st035614 2.80 33.8 µM 0.00410 22 0.00259 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.21E-25 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.118 5.87E-12 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.104 1.47E-9 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.101 4.64E-9 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.097 2.02E-8 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.091 1.16E-7 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.091 1.19E-7 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.087 4.38E-7 YPL041C_p YPL041C_p hom Protein of unknown function involved in maintenance of proper telomere length
0.086 5.59E-7 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.083 1.65E-6 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.081 2.83E-6 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.078 6.93E-6 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.075 1.20E-5 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.074 1.83E-5 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.073 2.10E-5 YDR465C RMT2 hom Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress