YER085C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YER085C / YER085C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.84|P-value:3.84E-8 ID:SGTC_57|Compound:miconazole|FD-Score:3.57|P-value:3.69E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:2.98|P-value:4.62E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.17|P-value:2.14E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.97|P-value:4.65E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-2.97|P-value:4.65E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:6.97|P-value:4.85E-15 ID:SGTC_361|Compound:000s-0510|FD-Score:13.50|P-value:2.77E-51 ID:SGTC_368|Compound:fentichlor|FD-Score:-2.87|P-value:6.82E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.48|P-value:5.52E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:4.41|P-value:4.92E-7 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.86|P-value:7.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:5.06|P-value:9.58E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.22|P-value:1.32E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.14|P-value:2.47E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.06|P-value:3.24E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.94|P-value:6.03E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:-2.80|P-value:9.12E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.22|P-value:1.37E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.35|P-value:6.63E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.85|P-value:7.64E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.05|P-value:3.56E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.29|P-value:9.51E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.52|P-value:4.65E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.00|P-value:4.18E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.10|P-value:2.87E-4 ID:SGTC_1717|Compound:st033143|FD-Score:2.88|P-value:6.92E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.16|P-value:2.14E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.57|P-value:3.52E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.23|P-value:1.66E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-6.77|P-value:2.49E-14 ID:SGTC_2411|Compound:st077133|FD-Score:4.87|P-value:3.15E-8 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.61|P-value:2.90E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.26|P-value:1.05E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-4.39|P-value:5.01E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-3.44|P-value:6.34E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-2.90|P-value:6.18E-4 ID:SGTC_2432|Compound:5630864|FD-Score:2.85|P-value:7.78E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.86|P-value:8.84E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.36|P-value:6.50E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.46|P-value:5.91E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.91|P-value:6.27E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.84|P-value:9.87E-6 ID:SGTC_2970|Compound:9090938|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.01|P-value:4.21E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.09|P-value:2.61E-6 ID:SGTC_3309|Compound:9129340|FD-Score:-2.92|P-value:5.63E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-4.26|P-value:1.02E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-3.68|P-value:2.04E-5 ID:SGTC_3340|Compound:9146634|FD-Score:5.11|P-value:6.75E-9 ID:SGTC_3347|Compound:9188721|FD-Score:2.97|P-value:4.92E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.84|P-value:3.84E-8 ID:SGTC_57|Compound:miconazole|FD-Score:3.57|P-value:3.69E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:2.98|P-value:4.62E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.17|P-value:2.14E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.97|P-value:4.65E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-2.97|P-value:4.65E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:6.97|P-value:4.85E-15 ID:SGTC_361|Compound:000s-0510|FD-Score:13.50|P-value:2.77E-51 ID:SGTC_368|Compound:fentichlor|FD-Score:-2.87|P-value:6.82E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.48|P-value:5.52E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:4.41|P-value:4.92E-7 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.86|P-value:7.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:5.06|P-value:9.58E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.22|P-value:1.32E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.14|P-value:2.47E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.06|P-value:3.24E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.94|P-value:6.03E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:-2.80|P-value:9.12E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.22|P-value:1.37E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.35|P-value:6.63E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.85|P-value:7.64E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.05|P-value:3.56E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.29|P-value:9.51E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.52|P-value:4.65E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.00|P-value:4.18E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.10|P-value:2.87E-4 ID:SGTC_1717|Compound:st033143|FD-Score:2.88|P-value:6.92E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.16|P-value:2.14E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.57|P-value:3.52E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.23|P-value:1.66E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-6.77|P-value:2.49E-14 ID:SGTC_2411|Compound:st077133|FD-Score:4.87|P-value:3.15E-8 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.61|P-value:2.90E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.26|P-value:1.05E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-4.39|P-value:5.01E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-3.44|P-value:6.34E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-2.90|P-value:6.18E-4 ID:SGTC_2432|Compound:5630864|FD-Score:2.85|P-value:7.78E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.86|P-value:8.84E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.36|P-value:6.50E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.46|P-value:5.91E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.91|P-value:6.27E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.84|P-value:9.87E-6 ID:SGTC_2970|Compound:9090938|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.01|P-value:4.21E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.09|P-value:2.61E-6 ID:SGTC_3309|Compound:9129340|FD-Score:-2.92|P-value:5.63E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-4.26|P-value:1.02E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-3.68|P-value:2.04E-5 ID:SGTC_3340|Compound:9146634|FD-Score:5.11|P-value:6.75E-9 ID:SGTC_3347|Compound:9188721|FD-Score:2.97|P-value:4.92E-4

Top fitness defect scores for YER085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_361 000s-0510 13.50 1.4 µM 2.77E-51 1 7.10E-42
2 SGTC_353 1988-1175 6.97 58.3 µM 4.85E-15 unfolded protein response 7 1.62E-12
3 SGTC_3340 9146634 5.11 11.1 µM 6.75E-9 4 1.60E-7
4 SGTC_516 3992-2719 5.06 87.3 µM 9.58E-9 7 2.13E-7
5 SGTC_2411 st077133 4.87 39.9 µM 3.15E-8 RNA pol III & RNase P/MRP 15 5.61E-7
6 SGTC_8 0354-0001 4.84 70.0 µM 3.84E-8 48 6.59E-7
7 SGTC_432 NS 1619 4.41 61.3 µM 4.92E-7 21 5.27E-6
8 SGTC_2611 pyromycin 4.36 23.9 µM 6.50E-7 17 6.61E-6
9 SGTC_1247 0448-0043 4.35 5.8 µM 6.63E-7 ERG2 28 6.72E-6
10 SGTC_1263 0774-1208 4.29 64.8 µM 9.51E-7 34 9.02E-6
11 SGTC_1132 3456-3614 4.22 2.5 µM 1.37E-6 tubulin folding & SWR complex 32 1.21E-5
12 SGTC_1119 parthenolide 3.94 318.5 nM 6.03E-6 TSC3-RPN4 38 4.07E-5
13 SGTC_2436 5633522 3.86 8.1 µM 8.84E-6 18 5.57E-5
14 SGTC_2891 9063876 3.84 19.5 µM 9.87E-6 9 6.10E-5
15 SGTC_57 miconazole 3.57 162.5 nM 3.69E-5 ergosterol depletion effects on membrane 34 1.79E-4
16 SGTC_1277 0873-0036 3.52 22.0 µM 4.65E-5 PDR1 37 2.17E-4
17 SGTC_393 acivicin 3.48 6.2 µM 5.52E-5 27 2.49E-4
18 SGTC_2131 toluylene red 3.23 5.3 µM 1.66E-4 60S ribosome export 57 6.15E-4
19 SGTC_198 3454-2873 3.17 16.2 µM 2.14E-4 60S ribosome export 36 7.57E-4
20 SGTC_996 3970-0799 3.14 1.8 µM 2.47E-4 143 8.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.36E-18 YIL047C SYG1 hom Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
0.134 8.04E-15 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.126 2.20E-13 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.125 3.48E-13 YDL112W TRM3 hom 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.122 1.07E-12 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.120 3.21E-12 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.119 4.93E-12 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.116 1.52E-11 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.116 1.78E-11 YLR286C CTS1 hom Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
0.115 2.17E-11 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.113 4.57E-11 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.113 5.19E-11 YOR324C FRT1 hom Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication
0.113 5.58E-11 YOR123C LEO1 hom Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.110 1.64E-10 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.107 4.74E-10 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene