YER087C-A_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase

Zygosity: Homozygous strain
fixedexpanded
Profile for YER087C-A / YER087C-A

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.85|P-value:5.85E-10 ID:SGTC_61|Compound:0978-8327|FD-Score:3.88|P-value:2.69E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.85|P-value:5.79E-10 ID:SGTC_67|Compound:0335-0847|FD-Score:6.54|P-value:5.23E-12 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.98|P-value:1.92E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.63|P-value:1.09E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:3.01|P-value:8.64E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.60|P-value:8.90E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:4.34|P-value:3.11E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:6.16|P-value:7.41E-11 ID:SGTC_343|Compound:4130-2827|FD-Score:6.34|P-value:2.17E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:4.31|P-value:3.64E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.47|P-value:1.63E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:2.99|P-value:9.27E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.99|P-value:9.79E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.10|P-value:6.08E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.06|P-value:7.08E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.39|P-value:2.24E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.23|P-value:3.80E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.66|P-value:6.84E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.88|P-value:2.96E-5 ID:SGTC_1708|Compound:st033234|FD-Score:3.68|P-value:6.39E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.34|P-value:3.48E-6 ID:SGTC_1807|Compound:st050092|FD-Score:-3.16|P-value:5.38E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.80|P-value:3.73E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.35|P-value:2.38E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.26|P-value:3.46E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.06|P-value:7.09E-4 ID:SGTC_1938|Compound:st074717|FD-Score:5.06|P-value:7.01E-8 ID:SGTC_1948|Compound:st076329|FD-Score:6.74|P-value:1.18E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.29|P-value:4.51E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.66|P-value:6.87E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-5.30|P-value:2.00E-8 ID:SGTC_2285|Compound:7945142|FD-Score:-3.16|P-value:5.44E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.04|P-value:8.43E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.40|P-value:2.20E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.11|P-value:5.98E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.20|P-value:4.21E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:10.20|P-value:2.21E-26 ID:SGTC_2469|Compound:5655019|FD-Score:3.59|P-value:9.31E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.12|P-value:5.69E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.41|P-value:2.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.25|P-value:3.50E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.51|P-value:1.43E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.46|P-value:1.55E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.85|P-value:5.85E-10 ID:SGTC_61|Compound:0978-8327|FD-Score:3.88|P-value:2.69E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.85|P-value:5.79E-10 ID:SGTC_67|Compound:0335-0847|FD-Score:6.54|P-value:5.23E-12 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.98|P-value:1.92E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.63|P-value:1.09E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:3.01|P-value:8.64E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.60|P-value:8.90E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:4.34|P-value:3.11E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:6.16|P-value:7.41E-11 ID:SGTC_343|Compound:4130-2827|FD-Score:6.34|P-value:2.17E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:4.31|P-value:3.64E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.47|P-value:1.63E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:2.99|P-value:9.27E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.99|P-value:9.79E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.10|P-value:6.08E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.06|P-value:7.08E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.39|P-value:2.24E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.23|P-value:3.80E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.66|P-value:6.84E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.88|P-value:2.96E-5 ID:SGTC_1708|Compound:st033234|FD-Score:3.68|P-value:6.39E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.34|P-value:3.48E-6 ID:SGTC_1807|Compound:st050092|FD-Score:-3.16|P-value:5.38E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.80|P-value:3.73E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.35|P-value:2.38E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.26|P-value:3.46E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.06|P-value:7.09E-4 ID:SGTC_1938|Compound:st074717|FD-Score:5.06|P-value:7.01E-8 ID:SGTC_1948|Compound:st076329|FD-Score:6.74|P-value:1.18E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.29|P-value:4.51E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.66|P-value:6.87E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-5.30|P-value:2.00E-8 ID:SGTC_2285|Compound:7945142|FD-Score:-3.16|P-value:5.44E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.04|P-value:8.43E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.40|P-value:2.20E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.11|P-value:5.98E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.20|P-value:4.21E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:10.20|P-value:2.21E-26 ID:SGTC_2469|Compound:5655019|FD-Score:3.59|P-value:9.31E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.12|P-value:5.69E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.41|P-value:2.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.25|P-value:3.50E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.51|P-value:1.43E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.46|P-value:1.55E-4

Top fitness defect scores for YER087C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2407 paclitaxel 10.20 400.0 µM 2.21E-26 1 1.48E-24
2 SGTC_137 0438-0332 7.63 85.4 µM 1.09E-15 ubiquinone biosynthesis & proteasome 41 1.22E-14
3 SGTC_1948 st076329 6.74 66.6 µM 1.18E-12 2 7.92E-12
4 SGTC_67 0335-0847 6.54 266.0 µM 5.23E-12 ubiquinone biosynthesis & proteasome 57 3.14E-11
5 SGTC_343 4130-2827 6.34 29.8 µM 2.17E-11 4 1.18E-10
6 SGTC_340 k038-0059 6.16 454.0 µM 7.41E-11 ubiquinone biosynthesis & proteasome 18 3.67E-10
7 SGTC_64 000l-0018 5.85 272.1 µM 5.79E-10 ubiquinone biosynthesis & proteasome 82 2.47E-9
8 SGTC_16 erodoxin 5.85 22.8 µM 5.85E-10 unfolded protein response 28 2.49E-9
9 SGTC_1938 st074717 5.06 56.4 µM 7.01E-8 5 2.11E-7
10 SGTC_320 4092-0846 4.34 5.3 µM 3.11E-6 ergosterol depletion effects on membrane 39 7.12E-6
11 SGTC_367 0335-0881 4.31 7.1 µM 3.64E-6 ubiquinone biosynthesis & proteasome 58 8.25E-6
12 SGTC_61 0978-8327 3.88 98.6 µM 2.69E-5 ergosterol biosynthesis 32 5.28E-5
13 SGTC_1823 3-hydroxy-2-naphthoic acid 3.80 106.0 µM 3.73E-5 20 7.15E-5
14 SGTC_1708 st033234 3.68 31.8 µM 6.39E-5 23 1.18E-4
15 SGTC_1567 st069303 3.66 68.4 µM 6.84E-5 mitochondrial processes 26 1.25E-4
16 SGTC_2045 5106652 3.66 78.0 µM 6.87E-5 20 1.26E-4
17 SGTC_165 k038-0023 3.60 64.4 µM 8.90E-5 ubiquinone biosynthesis & proteasome 96 1.60E-4
18 SGTC_2469 5655019 3.59 90.8 µM 9.31E-5 29 1.67E-4
19 SGTC_2940 9060638 3.46 45.9 µM 1.55E-4 amide catabolism 42 2.69E-4
20 SGTC_1924 st058459 3.35 75.1 µM 2.38E-4 25 4.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 2.84E-55 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.264 1.09E-54 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.260 8.49E-53 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.245 3.08E-47 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.243 3.18E-46 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.231 6.44E-42 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.227 2.67E-40 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.225 7.75E-40 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.223 5.98E-39 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.218 2.66E-37 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.210 1.31E-34 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.203 1.73E-32 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.198 4.65E-31 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.191 8.63E-29 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.186 1.29E-27 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication