YER087C-B / SBH1

Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER087C-B / SBH1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:7.81|P-value:7.44E-12 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.99|P-value:2.40E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:9.10|P-value:1.75E-15 ID:SGTC_236|Compound:1509-0011|FD-Score:3.71|P-value:6.96E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.45|P-value:5.13E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:5.12|P-value:5.01E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:4.34|P-value:9.25E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:6.74|P-value:2.97E-9 ID:SGTC_635|Compound:k038-0028|FD-Score:5.48|P-value:1.15E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.90|P-value:3.29E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.65|P-value:8.52E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:6.26|P-value:3.25E-8 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.93|P-value:1.05E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.64|P-value:8.77E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.11|P-value:5.25E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.63|P-value:8.82E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.27|P-value:1.19E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.40|P-value:1.62E-6 ID:SGTC_1612|Compound:st002233|FD-Score:4.03|P-value:2.56E-4 ID:SGTC_1694|Compound:st024011|FD-Score:5.11|P-value:5.26E-6 ID:SGTC_1740|Compound:st038286|FD-Score:5.01|P-value:7.75E-6 ID:SGTC_1773|Compound:st048542|FD-Score:5.45|P-value:1.29E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.47|P-value:4.76E-5 ID:SGTC_1836|Compound:st055642|FD-Score:4.45|P-value:6.35E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.59|P-value:8.45E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.80|P-value:1.75E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.95|P-value:2.81E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.21|P-value:1.42E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.64|P-value:8.77E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.68|P-value:2.19E-5 ID:SGTC_2237|Compound:6667747|FD-Score:6.27|P-value:3.02E-8 ID:SGTC_2265|Compound:7929201|FD-Score:6.63|P-value:5.13E-9 ID:SGTC_2286|Compound:7945697|FD-Score:4.19|P-value:1.55E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.08|P-value:1.82E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.85|P-value:4.59E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.23|P-value:1.34E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.84|P-value:4.71E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:7.71|P-value:1.32E-11 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.24|P-value:3.04E-6 ID:SGTC_2852|Compound:9023854|FD-Score:-4.27|P-value:9.44E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.59|P-value:8.35E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-6.68|P-value:2.91E-9 ID:SGTC_2965|Compound:9082772|FD-Score:-4.57|P-value:3.31E-5 ID:SGTC_2989|Compound:9073649|FD-Score:-4.86|P-value:1.12E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.77|P-value:5.86E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.02|P-value:7.47E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-3.82|P-value:4.21E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.86|P-value:1.40E-5 ID:SGTC_3196|Compound:9111891|FD-Score:5.58|P-value:7.21E-7 ID:SGTC_3197|Compound:9113331|FD-Score:-6.03|P-value:7.25E-8 ID:SGTC_3199|Compound:9111318|FD-Score:-8.17|P-value:5.72E-13 ID:SGTC_16|Compound:erodoxin|FD-Score:7.81|P-value:7.44E-12 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.99|P-value:2.40E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:9.10|P-value:1.75E-15 ID:SGTC_236|Compound:1509-0011|FD-Score:3.71|P-value:6.96E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.45|P-value:5.13E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:5.12|P-value:5.01E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:4.34|P-value:9.25E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:6.74|P-value:2.97E-9 ID:SGTC_635|Compound:k038-0028|FD-Score:5.48|P-value:1.15E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.90|P-value:3.29E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.65|P-value:8.52E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:6.26|P-value:3.25E-8 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.93|P-value:1.05E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.64|P-value:8.77E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.11|P-value:5.25E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.63|P-value:8.82E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.27|P-value:1.19E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.40|P-value:1.62E-6 ID:SGTC_1612|Compound:st002233|FD-Score:4.03|P-value:2.56E-4 ID:SGTC_1694|Compound:st024011|FD-Score:5.11|P-value:5.26E-6 ID:SGTC_1740|Compound:st038286|FD-Score:5.01|P-value:7.75E-6 ID:SGTC_1773|Compound:st048542|FD-Score:5.45|P-value:1.29E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.47|P-value:4.76E-5 ID:SGTC_1836|Compound:st055642|FD-Score:4.45|P-value:6.35E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.59|P-value:8.45E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.80|P-value:1.75E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.95|P-value:2.81E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.21|P-value:1.42E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.64|P-value:8.77E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.68|P-value:2.19E-5 ID:SGTC_2237|Compound:6667747|FD-Score:6.27|P-value:3.02E-8 ID:SGTC_2265|Compound:7929201|FD-Score:6.63|P-value:5.13E-9 ID:SGTC_2286|Compound:7945697|FD-Score:4.19|P-value:1.55E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.08|P-value:1.82E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.85|P-value:4.59E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.23|P-value:1.34E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.84|P-value:4.71E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:7.71|P-value:1.32E-11 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.24|P-value:3.04E-6 ID:SGTC_2852|Compound:9023854|FD-Score:-4.27|P-value:9.44E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.59|P-value:8.35E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-6.68|P-value:2.91E-9 ID:SGTC_2965|Compound:9082772|FD-Score:-4.57|P-value:3.31E-5 ID:SGTC_2989|Compound:9073649|FD-Score:-4.86|P-value:1.12E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.77|P-value:5.86E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.02|P-value:7.47E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-3.82|P-value:4.21E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.86|P-value:1.40E-5 ID:SGTC_3196|Compound:9111891|FD-Score:5.58|P-value:7.21E-7 ID:SGTC_3197|Compound:9113331|FD-Score:-6.03|P-value:7.25E-8 ID:SGTC_3199|Compound:9111318|FD-Score:-8.17|P-value:5.72E-13

Top fitness defect scores for YER087C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_137 0438-0332 9.10 85.4 µM 1.75E-15 ubiquinone biosynthesis & proteasome 28 4.41E-20
2 SGTC_16 erodoxin 7.81 22.8 µM 7.44E-12 unfolded protein response 15 2.88E-15
3 SGTC_2626 ethyl orsellinate 7.71 100.0 µM 1.32E-11 2 6.20E-15
4 SGTC_541 4513-1321 6.74 94.0 µM 2.97E-9 3 8.12E-12
5 SGTC_2265 7929201 6.63 200.0 µM 5.13E-9 5 1.68E-11
6 SGTC_2237 6667747 6.27 47.2 µM 3.02E-8 3 1.75E-10
7 SGTC_1028 k015-0029 6.26 4.8 µM 3.25E-8 1 1.93E-10
8 SGTC_3196 9111891 5.58 49.5 µM 7.21E-7 mitochondrial processes 3 1.17E-8
9 SGTC_635 k038-0028 5.48 24.7 µM 1.15E-6 ubiquinone biosynthesis & proteasome 21 2.17E-8
10 SGTC_1773 st048542 5.45 73.6 µM 1.29E-6 22 2.52E-8
11 SGTC_1506 4226-2149 5.40 212.0 µM 1.62E-6 7 3.41E-8
12 SGTC_2628 lathosterol 5.24 100.0 µM 3.04E-6 9 7.85E-8
13 SGTC_537 1334-0398 5.12 209.0 µM 5.01E-6 8 1.52E-7
14 SGTC_1241 0364-0022 5.11 50.8 µM 5.25E-6 ERG2 13 1.62E-7
15 SGTC_1694 st024011 5.11 44.9 µM 5.26E-6 ERG2 17 1.62E-7
16 SGTC_3059 1327-0034 5.02 3.0 µM 7.47E-6 34 2.58E-7
17 SGTC_1740 st038286 5.01 13.2 µM 7.75E-6 10 2.71E-7
18 SGTC_1183 1254-0324 4.93 198.0 µM 1.05E-5 6 4.06E-7
19 SGTC_3152 9099253 4.86 49.5 µM 1.40E-5 NEO1-PIK1 84 5.89E-7
20 SGTC_1910 st062352 4.80 60.4 µM 1.75E-5 14 7.93E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.18E-12 YBR072C-A_p YBR072C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.121 1.91E-12 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.121 2.29E-12 YHL023C NPR3 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair
0.119 4.04E-12 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.119 4.11E-12 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.114 3.93E-11 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.113 5.86E-11 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.106 6.55E-10 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.102 2.64E-9 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.102 2.90E-9 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.102 3.39E-9 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.102 3.53E-9 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.100 7.36E-9 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.094 5.18E-8 YJL197W UBP12 hom Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm
0.093 5.98E-8 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs