YER087W / AIM10

Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YER087W / AIM10

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.15|P-value:3.95E-9 ID:SGTC_19|Compound:0279-0214|FD-Score:5.03|P-value:1.18E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.60|P-value:7.80E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.37|P-value:7.96E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.01|P-value:1.30E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.11|P-value:5.77E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.40|P-value:1.73E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:13.30|P-value:3.80E-36 ID:SGTC_236|Compound:1509-0011|FD-Score:9.67|P-value:5.26E-20 ID:SGTC_253|Compound:dyclonine|FD-Score:4.08|P-value:6.56E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.54|P-value:6.96E-13 ID:SGTC_283|Compound:0987-0079|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.00|P-value:2.35E-21 ID:SGTC_314|Compound:1671-0008|FD-Score:4.97|P-value:1.51E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.56|P-value:4.05E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.96|P-value:1.49E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.67|P-value:2.74E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.99|P-value:1.39E-6 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.96|P-value:9.52E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.65|P-value:6.51E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.32|P-value:9.36E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.06|P-value:6.97E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.15|P-value:4.92E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.32|P-value:8.78E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:5.18|P-value:5.92E-7 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.69|P-value:2.68E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.59|P-value:3.65E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.32|P-value:9.21E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.61|P-value:3.39E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.75|P-value:3.83E-6 ID:SGTC_1742|Compound:st038235|FD-Score:5.01|P-value:1.27E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.56|P-value:4.03E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.71|P-value:2.48E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.33|P-value:8.58E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.81|P-value:1.78E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.99|P-value:1.40E-6 ID:SGTC_1922|Compound:5578187|FD-Score:3.43|P-value:6.54E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.91|P-value:1.22E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.96|P-value:1.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.41|P-value:6.93E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.50|P-value:5.18E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.42|P-value:6.43E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.41|P-value:1.65E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.76|P-value:2.09E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.47|P-value:5.64E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.07|P-value:6.31E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.52|P-value:1.02E-5 ID:SGTC_2780|Compound:5215298|FD-Score:-7.43|P-value:1.32E-12 ID:SGTC_2781|Compound:5567276|FD-Score:-8.27|P-value:3.50E-15 ID:SGTC_2784|Compound:7567673|FD-Score:-3.94|P-value:1.02E-4 ID:SGTC_2785|Compound:7756463|FD-Score:5.38|P-value:2.15E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-3.63|P-value:3.18E-4 ID:SGTC_3075|Compound:9116269|FD-Score:4.84|P-value:2.83E-6 ID:SGTC_3218|Compound:9131285|FD-Score:4.55|P-value:9.90E-6 ID:SGTC_3282|Compound:9108498|FD-Score:3.33|P-value:8.90E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.15|P-value:3.95E-9 ID:SGTC_19|Compound:0279-0214|FD-Score:5.03|P-value:1.18E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.60|P-value:7.80E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.37|P-value:7.96E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.01|P-value:1.30E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.11|P-value:5.77E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.40|P-value:1.73E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:13.30|P-value:3.80E-36 ID:SGTC_236|Compound:1509-0011|FD-Score:9.67|P-value:5.26E-20 ID:SGTC_253|Compound:dyclonine|FD-Score:4.08|P-value:6.56E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.54|P-value:6.96E-13 ID:SGTC_283|Compound:0987-0079|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.00|P-value:2.35E-21 ID:SGTC_314|Compound:1671-0008|FD-Score:4.97|P-value:1.51E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.56|P-value:4.05E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.96|P-value:1.49E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.67|P-value:2.74E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.99|P-value:1.39E-6 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.96|P-value:9.52E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.65|P-value:6.51E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.32|P-value:9.36E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.06|P-value:6.97E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.15|P-value:4.92E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.32|P-value:8.78E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:5.18|P-value:5.92E-7 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.69|P-value:2.68E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.59|P-value:3.65E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.32|P-value:9.21E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.61|P-value:3.39E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.75|P-value:3.83E-6 ID:SGTC_1742|Compound:st038235|FD-Score:5.01|P-value:1.27E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.56|P-value:4.03E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.71|P-value:2.48E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.33|P-value:8.58E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.81|P-value:1.78E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.99|P-value:1.40E-6 ID:SGTC_1922|Compound:5578187|FD-Score:3.43|P-value:6.54E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.91|P-value:1.22E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.96|P-value:1.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.41|P-value:6.93E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.50|P-value:5.18E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.42|P-value:6.43E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.41|P-value:1.65E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.76|P-value:2.09E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.47|P-value:5.64E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.07|P-value:6.31E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.52|P-value:1.02E-5 ID:SGTC_2780|Compound:5215298|FD-Score:-7.43|P-value:1.32E-12 ID:SGTC_2781|Compound:5567276|FD-Score:-8.27|P-value:3.50E-15 ID:SGTC_2784|Compound:7567673|FD-Score:-3.94|P-value:1.02E-4 ID:SGTC_2785|Compound:7756463|FD-Score:5.38|P-value:2.15E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-3.63|P-value:3.18E-4 ID:SGTC_3075|Compound:9116269|FD-Score:4.84|P-value:2.83E-6 ID:SGTC_3218|Compound:9131285|FD-Score:4.55|P-value:9.90E-6 ID:SGTC_3282|Compound:9108498|FD-Score:3.33|P-value:8.90E-4

Top fitness defect scores for YER087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 13.30 2.7 µM 3.80E-36 mitochondrial stress 14 1.11E-40
2 SGTC_310 1273-0058 10.00 1.1 µM 2.35E-21 mitochondrial stress 41 5.99E-24
3 SGTC_236 1509-0011 9.67 5.3 µM 5.26E-20 202 2.01E-22
4 SGTC_275 trichlorophene 7.54 5.7 µM 6.96E-13 mitochondrial stress 84 2.27E-14
5 SGTC_10 0279-0212 6.15 42.6 µM 3.95E-9 TRP & mitochondrial translation 26 3.97E-10
6 SGTC_2785 7756463 5.38 72.7 µM 2.15E-7 6 3.63E-8
7 SGTC_1332 1480-0653 5.18 17.5 µM 5.92E-7 TSC3-RPN4 5 1.13E-7
8 SGTC_19 0279-0214 5.03 38.4 µM 1.18E-6 TRP & mitochondrial translation 20 2.48E-7
9 SGTC_1742 st038235 5.01 28.9 µM 1.27E-6 mitochondrial stress 74 2.68E-7
10 SGTC_68 0986-0284 5.01 82.8 µM 1.30E-6 32 2.75E-7
11 SGTC_717 1532-0246 4.99 73.2 µM 1.39E-6 Golgi 12 2.97E-7
12 SGTC_1883 5-benzylidenerhodanine 4.99 20.0 µM 1.40E-6 TRP & mitochondrial translation 31 2.99E-7
13 SGTC_314 1671-0008 4.97 2.7 µM 1.51E-6 23 3.27E-7
14 SGTC_3075 9116269 4.84 49.5 µM 2.83E-6 11 6.64E-7
15 SGTC_892 0929-0076 4.65 29.0 µM 6.51E-6 TRP & mitochondrial translation 23 1.70E-6
16 SGTC_28 pentachloropyridine N-oxide 4.60 1.6 µM 7.80E-6 TSC3-RPN4 40 2.08E-6
17 SGTC_3218 9131285 4.55 49.5 µM 9.90E-6 endomembrane recycling 27 2.72E-6
18 SGTC_1188 1403-0014 4.15 4.6 µM 4.92E-5 mitochondrial stress 45 1.66E-5
19 SGTC_70 0141-0289 4.11 43.3 µM 5.77E-5 mitochondrial stress 162 1.98E-5
20 SGTC_253 dyclonine 4.08 31.2 µM 6.56E-5 amide catabolism 22 2.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.494 1.29E-205 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.491 6.18E-203 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.485 1.39E-197 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.483 8.01E-196 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.481 1.35E-193 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.480 6.71E-193 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.479 2.99E-191 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.474 2.26E-187 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.469 3.68E-183 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.468 1.11E-182 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.468 5.77E-182 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.444 6.20E-162 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.443 5.16E-161 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.441 1.14E-159 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.441 1.47E-159 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit