YER092W / IES5

Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YER092W / IES5

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-3.46|P-value:8.43E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.19|P-value:7.99E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.34|P-value:2.95E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.68|P-value:3.20E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.86|P-value:1.74E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.81|P-value:2.72E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.60|P-value:4.26E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.82|P-value:4.18E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.70|P-value:3.83E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.48|P-value:6.33E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.58|P-value:4.53E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.44|P-value:7.22E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.86|P-value:3.50E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-4.05|P-value:1.14E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.89|P-value:1.56E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.08|P-value:7.96E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.27|P-value:5.59E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.92|P-value:1.85E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.62|P-value:4.97E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:4.26|P-value:4.12E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.41|P-value:7.73E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:5.86|P-value:3.11E-8 ID:SGTC_588|Compound:3970-1144|FD-Score:5.52|P-value:1.76E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:5.58|P-value:1.26E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:-7.33|P-value:1.10E-11 ID:SGTC_666|Compound:0272-0154|FD-Score:-4.28|P-value:4.95E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.48|P-value:6.37E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.66|P-value:3.42E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.68|P-value:3.26E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.63|P-value:3.89E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.07|P-value:8.22E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.85|P-value:2.32E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:7.52|P-value:2.01E-12 ID:SGTC_993|Compound:3909-8757|FD-Score:4.46|P-value:1.84E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.56|P-value:6.20E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.29|P-value:3.63E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.38|P-value:8.67E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.41|P-value:2.22E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.89|P-value:3.12E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:5.61|P-value:1.10E-7 ID:SGTC_1705|Compound:st027868|FD-Score:3.53|P-value:5.26E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.33|P-value:6.07E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.72|P-value:3.62E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.44|P-value:8.88E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.39|P-value:2.42E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.82|P-value:1.98E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.57|P-value:1.19E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.51|P-value:1.53E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.54|P-value:5.13E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.25|P-value:4.24E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.80|P-value:2.17E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.74|P-value:3.38E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.90|P-value:4.03E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-3.86|P-value:2.25E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.43|P-value:7.46E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.53|P-value:5.40E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.35|P-value:2.87E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.42|P-value:7.47E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.46|P-value:8.53E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.47|P-value:6.53E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.61|P-value:5.15E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.32|P-value:3.24E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.70|P-value:6.91E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.97|P-value:2.17E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.73|P-value:2.75E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.75|P-value:5.73E-6 ID:SGTC_2801|Compound:7907800|FD-Score:3.72|P-value:2.89E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.95|P-value:1.63E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.71|P-value:3.80E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.59|P-value:4.35E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.46|P-value:6.68E-4 ID:SGTC_3233|Compound:9132340|FD-Score:5.40|P-value:3.02E-7 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.46|P-value:8.43E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.19|P-value:7.99E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.34|P-value:2.95E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.68|P-value:3.20E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.86|P-value:1.74E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.81|P-value:2.72E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.60|P-value:4.26E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.82|P-value:4.18E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.70|P-value:3.83E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.48|P-value:6.33E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.58|P-value:4.53E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.44|P-value:7.22E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.86|P-value:3.50E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-4.05|P-value:1.14E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.89|P-value:1.56E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.08|P-value:7.96E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.27|P-value:5.59E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.92|P-value:1.85E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.62|P-value:4.97E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:4.26|P-value:4.12E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.41|P-value:7.73E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:5.86|P-value:3.11E-8 ID:SGTC_588|Compound:3970-1144|FD-Score:5.52|P-value:1.76E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:5.58|P-value:1.26E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:-7.33|P-value:1.10E-11 ID:SGTC_666|Compound:0272-0154|FD-Score:-4.28|P-value:4.95E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.48|P-value:6.37E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.66|P-value:3.42E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.68|P-value:3.26E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.63|P-value:3.89E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.07|P-value:8.22E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.85|P-value:2.32E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:7.52|P-value:2.01E-12 ID:SGTC_993|Compound:3909-8757|FD-Score:4.46|P-value:1.84E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.56|P-value:6.20E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.29|P-value:3.63E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.38|P-value:8.67E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.41|P-value:2.22E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.89|P-value:3.12E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:5.61|P-value:1.10E-7 ID:SGTC_1705|Compound:st027868|FD-Score:3.53|P-value:5.26E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.33|P-value:6.07E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.72|P-value:3.62E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.44|P-value:8.88E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.39|P-value:2.42E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.82|P-value:1.98E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.57|P-value:1.19E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.51|P-value:1.53E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.54|P-value:5.13E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.25|P-value:4.24E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.80|P-value:2.17E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.74|P-value:3.38E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.90|P-value:4.03E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-3.86|P-value:2.25E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.43|P-value:7.46E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.53|P-value:5.40E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.35|P-value:2.87E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.42|P-value:7.47E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.46|P-value:8.53E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.47|P-value:6.53E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.61|P-value:5.15E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.32|P-value:3.24E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.70|P-value:6.91E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.97|P-value:2.17E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.73|P-value:2.75E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.75|P-value:5.73E-6 ID:SGTC_2801|Compound:7907800|FD-Score:3.72|P-value:2.89E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.95|P-value:1.63E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.71|P-value:3.80E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.59|P-value:4.35E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.46|P-value:6.68E-4 ID:SGTC_3233|Compound:9132340|FD-Score:5.40|P-value:3.02E-7

Top fitness defect scores for YER092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_952 1185-0122 7.52 232.0 µM 2.01E-12 3 2.66E-14
2 SGTC_453 enantio-paf c16 6.62 10.0 µM 4.97E-10 32 1.76E-11
3 SGTC_539 4859-0462 5.86 2.5 µM 3.11E-8 RNA pol III & RNase P/MRP 3 2.28E-9
4 SGTC_2581 avocatin a 5.70 64.0 µM 6.91E-8 sphingolipid biosynthesis & PDR1 20 5.82E-9
5 SGTC_1399 3562-5772 5.61 25.0 µM 1.10E-7 RPP1 & pyrimidine depletion 4 1.00E-8
6 SGTC_653 0203-0016 5.58 55.2 µM 1.26E-7 4 1.18E-8
7 SGTC_588 3970-1144 5.52 52.9 µM 1.76E-7 5 1.74E-8
8 SGTC_3233 9132340 5.40 49.5 µM 3.02E-7 3 3.29E-8
9 SGTC_435 c-PAF 5.27 6.7 µM 5.59E-7 14 6.78E-8
10 SGTC_7 0192-1582 5.19 4.2 µM 7.99E-7 33 1.03E-7
11 SGTC_2582 agaric acid 4.97 100.0 µM 2.17E-6 redox potentiating 223 3.33E-7
12 SGTC_1280 0880-0253 4.89 10.1 µM 3.12E-6 4 5.10E-7
13 SGTC_378 3970-0959 4.86 8.3 µM 3.50E-6 7 5.82E-7
14 SGTC_158 k038-0087 4.82 26.4 µM 4.18E-6 ubiquinone biosynthesis & proteasome 94 7.18E-7
15 SGTC_2651 1327-0036 4.75 5.0 µM 5.73E-6 123 1.04E-6
16 SGTC_1941 st076221 4.57 61.8 µM 1.19E-5 sphingolipid biosynthesis & PDR1 56 2.44E-6
17 SGTC_1959 st077091 4.51 55.8 µM 1.53E-5 RPP1 & pyrimidine depletion 31 3.27E-6
18 SGTC_993 3909-8757 4.46 62.7 µM 1.84E-5 16 4.08E-6
19 SGTC_1279 0874-0590 4.41 65.2 µM 2.22E-5 26 5.08E-6
20 SGTC_1785 bathophenanthroline 4.39 24.0 µM 2.42E-5 heme requiring 32 5.62E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 5.88E-33 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.182 2.44E-26 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.176 1.20E-24 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.169 9.45E-23 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.158 3.56E-20 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.157 4.89E-20 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.157 5.14E-20 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex
0.155 1.93E-19 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 3.20E-19 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.146 2.11E-17 YFL013C IES1 hom Subunit of the INO80 chromatin remodeling complex
0.140 4.54E-16 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.134 8.21E-15 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.129 5.22E-14 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.126 2.63E-13 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.123 7.68E-13 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data