YER093C / TSC11

Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER093C / TSC11

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:2.97|P-value:6.60E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.79|P-value:2.20E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.19|P-value:3.34E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.63|P-value:5.36E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.28|P-value:1.97E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.24|P-value:2.36E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.15|P-value:3.85E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.41|P-value:1.17E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.15|P-value:3.39E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.07|P-value:4.56E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.50|P-value:7.75E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.51|P-value:7.56E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:5.02|P-value:3.10E-8 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.71|P-value:3.62E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.86|P-value:1.84E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.45|P-value:1.15E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.71|P-value:3.17E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.56|P-value:1.04E-12 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.70|P-value:3.28E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.89|P-value:1.59E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.25|P-value:2.25E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-2.96|P-value:7.83E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.01|P-value:6.53E-4 ID:SGTC_1640|Compound:st009078|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.46|P-value:9.28E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.89|P-value:1.34E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.02|P-value:5.56E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.51|P-value:7.56E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.12|P-value:3.79E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.34|P-value:1.56E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.24|P-value:2.67E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.37|P-value:1.38E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.94|P-value:7.46E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.76|P-value:2.96E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.03|P-value:5.35E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.22|P-value:2.55E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.44|P-value:1.01E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.06|P-value:4.68E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.28|P-value:1.95E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-3.80|P-value:2.44E-5 ID:SGTC_3122|Compound:9126309|FD-Score:-3.56|P-value:7.22E-5 ID:SGTC_3127|Compound:9126946|FD-Score:5.41|P-value:2.79E-9 ID:SGTC_3138|Compound:9097216|FD-Score:-3.22|P-value:2.95E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.60|P-value:5.20E-5 ID:SGTC_3186|Compound:9110464|FD-Score:3.16|P-value:3.18E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.25|P-value:2.26E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.25|P-value:2.33E-6 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:2.97|P-value:6.60E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.79|P-value:2.20E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.19|P-value:3.34E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.63|P-value:5.36E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.28|P-value:1.97E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.24|P-value:2.36E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.15|P-value:3.85E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.41|P-value:1.17E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.15|P-value:3.39E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.07|P-value:4.56E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.50|P-value:7.75E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.51|P-value:7.56E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:5.02|P-value:3.10E-8 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.71|P-value:3.62E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.86|P-value:1.84E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.45|P-value:1.15E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.71|P-value:3.17E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.56|P-value:1.04E-12 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.70|P-value:3.28E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.89|P-value:1.59E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.25|P-value:2.25E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-2.96|P-value:7.83E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.01|P-value:6.53E-4 ID:SGTC_1640|Compound:st009078|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.46|P-value:9.28E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.89|P-value:1.34E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.02|P-value:5.56E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.51|P-value:7.56E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.12|P-value:3.79E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.34|P-value:1.56E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.24|P-value:2.67E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.37|P-value:1.38E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.94|P-value:7.46E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.76|P-value:2.96E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.03|P-value:5.35E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.22|P-value:2.55E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.44|P-value:1.01E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.06|P-value:4.68E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.28|P-value:1.95E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-3.80|P-value:2.44E-5 ID:SGTC_3122|Compound:9126309|FD-Score:-3.56|P-value:7.22E-5 ID:SGTC_3127|Compound:9126946|FD-Score:5.41|P-value:2.79E-9 ID:SGTC_3138|Compound:9097216|FD-Score:-3.22|P-value:2.95E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.60|P-value:5.20E-5 ID:SGTC_3186|Compound:9110464|FD-Score:3.16|P-value:3.18E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.25|P-value:2.26E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.25|P-value:2.33E-6

Top fitness defect scores for YER093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3127 9126946 5.41 49.5 µM 2.79E-9 ERG2 4 3.17E-8 0.10
2 SGTC_634 1611-4317 5.02 11.2 µM 3.10E-8 ERG2 3 2.56E-7 0.46
3 SGTC_3327 9140648 4.25 26.9 µM 2.33E-6 9 1.09E-5 0.09
4 SGTC_1877 wortmannin 3.89 25.0 µM 1.34E-5 12 4.99E-5 0.09
5 SGTC_65 0798-0905 3.79 35.0 µM 2.20E-5 calcium & mitochondrial duress 10 7.69E-5 0.01
6 SGTC_1213 1315-0166 3.71 115.0 µM 3.17E-5 19 1.05E-4 0.02
7 SGTC_1411 3909-8223 3.70 150.0 µM 3.28E-5 2 1.09E-4 0.24
8 SGTC_3155 9099265 3.60 49.5 µM 5.20E-5 7 1.62E-4 0.11
9 SGTC_1916 st067606 3.51 49.2 µM 7.56E-5 10 2.24E-4 0.00
10 SGTC_632 0781-2353 3.51 4.7 µM 7.56E-5 Golgi 24 2.24E-4 0.09
11 SGTC_623 k072-0108 3.50 16.9 µM 7.75E-5 heme biosynthesis & mitochondrial translocase 17 2.29E-4 0.10
12 SGTC_1645 Cervolide 3.46 78.0 µM 9.28E-5 6 2.68E-4 0.04
13 SGTC_2757 clomiphene 3.44 4.2 µM 1.01E-4 fatty acid desaturase (OLE1) 22 2.89E-4 0.03
14 SGTC_542 3381-0244 3.41 89.3 µM 1.17E-4 10 3.29E-4 0.09
15 SGTC_2248 tofa 3.37 1.1 µM 1.38E-4 sphingolipid biosynthesis & PDR1 37 3.78E-4 0.03
16 SGTC_2101 5377231 3.34 179.2 µM 1.56E-4 10 4.21E-4 0.21
17 SGTC_3008 9078912 3.28 71.4 µM 1.95E-4 6 5.13E-4 0.06
18 SGTC_184 1494-0393 3.28 24.7 µM 1.97E-4 45 5.16E-4 0.01
19 SGTC_1510 1123-0200 3.25 71.5 µM 2.25E-4 26 5.80E-4 0.00
20 SGTC_3214 9129694 3.25 49.5 µM 2.26E-4 11 5.82E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.34E-11 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.116 1.90E-11 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.115 2.32E-11 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.114 3.23E-11 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.114 4.19E-11 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.108 3.37E-10 YGL217C_d YGL217C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
0.104 1.59E-9 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.102 3.59E-9 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.100 5.86E-9 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.099 9.55E-9 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.098 1.44E-8 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.096 2.33E-8 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.096 2.47E-8 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress
0.093 7.56E-8 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.092 9.49E-8 YPL122C TFB2 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH