YER093C-A / AIM11

Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER093C-A / AIM11

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:4.89|P-value:1.42E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.14|P-value:4.52E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.98|P-value:9.04E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.12|P-value:7.93E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:5.22|P-value:2.11E-8 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.39|P-value:1.69E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.36|P-value:2.14E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.11|P-value:5.05E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.96|P-value:9.90E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.12|P-value:5.42E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.97|P-value:9.54E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.89|P-value:1.42E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.44|P-value:1.64E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.02|P-value:7.71E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.10|P-value:5.92E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.08|P-value:6.20E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.21|P-value:3.82E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.13|P-value:4.66E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.40|P-value:2.02E-6 ID:SGTC_1871|Compound:st057448|FD-Score:4.52|P-value:1.08E-6 ID:SGTC_2159|Compound:5658611|FD-Score:3.14|P-value:5.02E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.80|P-value:2.34E-7 ID:SGTC_2313|Compound:7726885|FD-Score:3.09|P-value:6.12E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.53|P-value:9.65E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.18|P-value:5.97E-6 ID:SGTC_2340|Compound:7987427|FD-Score:4.58|P-value:7.72E-7 ID:SGTC_2365|Compound:9042475|FD-Score:2.98|P-value:9.05E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:4.08E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.19|P-value:3.71E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-4.69|P-value:3.57E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.46|P-value:5.18E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.60|P-value:6.02E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.13|P-value:5.21E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.77|P-value:3.88E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.71|P-value:4.99E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.13|P-value:5.17E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.31|P-value:2.60E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.18|P-value:5.91E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.95|P-value:1.71E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.25|P-value:2.92E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.14|P-value:5.12E-4 ID:SGTC_3295|Compound:9122362|FD-Score:2.99|P-value:8.83E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.21|P-value:4.96E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:4.89|P-value:1.42E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.14|P-value:4.52E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.98|P-value:9.04E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.12|P-value:7.93E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:5.22|P-value:2.11E-8 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.39|P-value:1.69E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.36|P-value:2.14E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.11|P-value:5.05E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.96|P-value:9.90E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.12|P-value:5.42E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.97|P-value:9.54E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.89|P-value:1.42E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.44|P-value:1.64E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.02|P-value:7.71E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.10|P-value:5.92E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.08|P-value:6.20E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.21|P-value:3.82E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.13|P-value:4.66E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.40|P-value:2.02E-6 ID:SGTC_1871|Compound:st057448|FD-Score:4.52|P-value:1.08E-6 ID:SGTC_2159|Compound:5658611|FD-Score:3.14|P-value:5.02E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.80|P-value:2.34E-7 ID:SGTC_2313|Compound:7726885|FD-Score:3.09|P-value:6.12E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.53|P-value:9.65E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.18|P-value:5.97E-6 ID:SGTC_2340|Compound:7987427|FD-Score:4.58|P-value:7.72E-7 ID:SGTC_2365|Compound:9042475|FD-Score:2.98|P-value:9.05E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:4.08E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.19|P-value:3.71E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-4.69|P-value:3.57E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.46|P-value:5.18E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.60|P-value:6.02E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.13|P-value:5.21E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.77|P-value:3.88E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.71|P-value:4.99E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.13|P-value:5.17E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.31|P-value:2.60E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.18|P-value:5.91E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.95|P-value:1.71E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.25|P-value:2.92E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.14|P-value:5.12E-4 ID:SGTC_3295|Compound:9122362|FD-Score:2.99|P-value:8.83E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.21|P-value:4.96E-6

Top fitness defect scores for YER093C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 5.46 64.0 µM 5.18E-9 sphingolipid biosynthesis & PDR1 27 2.45E-8
2 SGTC_284 0988-0104 5.22 32.6 µM 2.11E-8 heme requiring 3 8.77E-8
3 SGTC_49 0717-0965 4.89 32.1 µM 1.42E-7 60S ribosome export 6 4.95E-7
4 SGTC_1245 0418-0076 4.89 17.2 µM 1.42E-7 ERG2 12 4.95E-7
5 SGTC_2208 7283366 4.80 200.0 µM 2.34E-7 5 7.80E-7
6 SGTC_2340 7987427 4.58 183.4 µM 7.72E-7 20 2.31E-6
7 SGTC_1871 st057448 4.52 67.3 µM 1.08E-6 13 3.14E-6
8 SGTC_1504 k297-0033 4.44 30.0 µM 1.64E-6 7 4.57E-6
9 SGTC_1697 st025554 4.40 27.7 µM 2.02E-6 18 5.52E-6
10 SGTC_3300 9124615 4.21 50.5 µM 4.96E-6 15 1.25E-5
11 SGTC_2991 9074669 4.18 71.4 µM 5.91E-6 azole & statin 51 1.47E-5
12 SGTC_2336 9001819 4.18 198.7 µM 5.97E-6 heme biosynthesis & mitochondrial translocase 44 1.48E-5
13 SGTC_274 sirtinol 4.12 40.1 µM 7.93E-6 16 1.92E-5
14 SGTC_2999 9069765 3.95 71.4 µM 1.71E-5 amide catabolism 24 3.86E-5
15 SGTC_2773 thioridazine 3.77 9.1 µM 3.88E-5 15 8.14E-5
16 SGTC_2415 st077333 3.76 57.7 µM 4.08E-5 53 8.52E-5
17 SGTC_2792 7535235 3.71 81.8 µM 4.99E-5 fatty acid desaturase (OLE1) 40 1.02E-4
18 SGTC_2205 7238770 3.40 200.0 µM 1.86E-4 11 3.40E-4
19 SGTC_590 k048-0076 3.36 22.4 µM 2.14E-4 RSC & ERG11 25 3.86E-4
20 SGTC_2825 7998094 3.31 58.4 µM 2.60E-4 fatty acid desaturase (OLE1) 52 4.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.87E-18 YMR244W_p YMR244W_p hom Putative protein of unknown function
0.119 3.77E-12 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.110 1.83E-10 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.103 2.03E-9 YIL121W QDR2 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.103 2.04E-9 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.096 2.16E-8 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.091 1.45E-7 YPL184C MRN1 hom RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation
0.091 1.48E-7 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.087 5.01E-7 YDR109C_p YDR109C_p hom Putative kinase
0.087 5.16E-7 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.086 5.40E-7 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.086 5.88E-7 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 9.60E-7 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.084 1.02E-6 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.084 1.07E-6 YDR156W RPA14 hom RNA polymerase I subunit A14