Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YER094C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.581 | 4.21E-302 | YMR314W | PRE5 | het | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.486 | 1.14E-198 | YFR050C | PRE4 | het | Beta 7 subunit of the 20S proteasome |
0.479 | 6.74E-192 | YOL038W | PRE6 | het | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
0.478 | 2.68E-191 | YOR362C | PRE10 | het | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.478 | 3.57E-191 | YGL011C | SCL1 | het | Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria |
0.469 | 2.22E-183 | YGR253C | PUP2 | het | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
0.468 | 9.67E-182 | YML092C | PRE8 | het | Alpha 2 subunit of the 20S proteasome |
0.426 | 8.23E-148 | YBL041W | PRE7 | het | Beta 6 subunit of the 20S proteasome |
0.390 | 4.45E-122 | YJL001W | PRE3 | het | Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides |
0.374 | 3.80E-112 | YER012W | PRE1 | het | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
0.370 | 4.89E-109 | YLR021W | IRC25 | hom | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
0.318 | 7.94E-80 | YNL111C | CYB5 | hom | Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation |
0.289 | 1.97E-65 | YPR146C_d | YPR146C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.282 | 2.16E-62 | YPR103W | PRE2 | het | Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome |
0.280 | 1.36E-61 | YPL144W | POC4 | hom | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |