YER095W / RAD51

Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YER095W / RAD51

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.72|P-value:4.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.59|P-value:3.16E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:6.64|P-value:1.66E-9 ID:SGTC_93|Compound:0109-0045|FD-Score:5.93|P-value:6.22E-8 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.59|P-value:6.30E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.59|P-value:6.99E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.05|P-value:3.56E-8 ID:SGTC_244|Compound:nsc-207895|FD-Score:4.69|P-value:1.47E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.16|P-value:1.06E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.53|P-value:2.74E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:4.60|P-value:2.08E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:4.18|P-value:9.86E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.94|P-value:2.26E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.76|P-value:1.12E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:4.41|P-value:4.34E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.69|P-value:5.10E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.99|P-value:4.44E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.74|P-value:4.42E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:7.09|P-value:1.34E-10 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.07|P-value:1.30E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.80|P-value:3.57E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.70|P-value:1.93E-7 ID:SGTC_836|Compound:0330-0104|FD-Score:3.77|P-value:3.96E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:5.81|P-value:1.12E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:4.18|P-value:9.99E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.92|P-value:5.12E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.63|P-value:1.87E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.65|P-value:5.87E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.30|P-value:6.43E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.14|P-value:1.01E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.83|P-value:8.53E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:6.26|P-value:1.25E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.29|P-value:7.35E-14 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.91|P-value:2.49E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.09|P-value:2.91E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.50|P-value:3.10E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.63|P-value:5.55E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.68|P-value:2.09E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.09|P-value:1.37E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.77|P-value:3.99E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.71|P-value:4.42E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:8.04|P-value:3.84E-13 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.69|P-value:1.99E-7 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.65|P-value:1.55E-9 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.98|P-value:1.97E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.52|P-value:7.81E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.07|P-value:1.44E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-4.17|P-value:9.34E-5 ID:SGTC_1620|Compound:st003704|FD-Score:4.39|P-value:4.63E-5 ID:SGTC_1655|Compound:st012546|FD-Score:4.48|P-value:3.39E-5 ID:SGTC_1707|Compound:st032323|FD-Score:6.17|P-value:1.96E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:4.50|P-value:3.05E-5 ID:SGTC_1813|Compound:st051246|FD-Score:5.00|P-value:4.25E-6 ID:SGTC_1845|Compound:st056753|FD-Score:5.34|P-value:1.00E-6 ID:SGTC_1846|Compound:st056244|FD-Score:4.44|P-value:3.83E-5 ID:SGTC_1849|Compound:st056239|FD-Score:4.06|P-value:1.51E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.39|P-value:4.72E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.69|P-value:5.13E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.02|P-value:1.73E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.67|P-value:5.49E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.63|P-value:5.61E-4 ID:SGTC_2088|Compound:5278280|FD-Score:5.64|P-value:2.54E-7 ID:SGTC_2192|Compound:5915882|FD-Score:4.19|P-value:9.48E-5 ID:SGTC_2200|Compound:6600604|FD-Score:4.32|P-value:5.95E-5 ID:SGTC_2204|Compound:7233102|FD-Score:5.27|P-value:1.34E-6 ID:SGTC_2360|Compound:9040895|FD-Score:6.23|P-value:1.39E-8 ID:SGTC_2381|Compound:9035592|FD-Score:3.61|P-value:6.56E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.24|P-value:8.16E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.61|P-value:6.64E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.14|P-value:1.16E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.88|P-value:2.49E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.00|P-value:2.26E-10 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-14.60|P-value:2.66E-39 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.85|P-value:7.74E-6 ID:SGTC_2671|Compound:danthron|FD-Score:5.86|P-value:8.91E-8 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.11|P-value:1.28E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.40|P-value:4.57E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.82|P-value:3.36E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.54|P-value:8.28E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.78|P-value:9.10E-6 ID:SGTC_3012|Compound:9080433|FD-Score:-4.10|P-value:1.17E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.90|P-value:6.42E-6 ID:SGTC_3050|Compound:9093513|FD-Score:4.22|P-value:8.59E-5 ID:SGTC_3247|Compound:9135149|FD-Score:6.13|P-value:2.30E-8 ID:SGTC_3254|Compound:9136651|FD-Score:6.97|P-value:2.62E-10 ID:SGTC_3330|Compound:9141424|FD-Score:4.45|P-value:3.74E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.72|P-value:4.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.59|P-value:3.16E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:6.64|P-value:1.66E-9 ID:SGTC_93|Compound:0109-0045|FD-Score:5.93|P-value:6.22E-8 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.59|P-value:6.30E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.59|P-value:6.99E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.05|P-value:3.56E-8 ID:SGTC_244|Compound:nsc-207895|FD-Score:4.69|P-value:1.47E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.16|P-value:1.06E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.53|P-value:2.74E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:4.60|P-value:2.08E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:4.18|P-value:9.86E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.94|P-value:2.26E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.76|P-value:1.12E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:4.41|P-value:4.34E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.69|P-value:5.10E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.99|P-value:4.44E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.74|P-value:4.42E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:7.09|P-value:1.34E-10 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.07|P-value:1.30E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.80|P-value:3.57E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.70|P-value:1.93E-7 ID:SGTC_836|Compound:0330-0104|FD-Score:3.77|P-value:3.96E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:5.81|P-value:1.12E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:4.18|P-value:9.99E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.92|P-value:5.12E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.63|P-value:1.87E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.65|P-value:5.87E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.30|P-value:6.43E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.14|P-value:1.01E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.83|P-value:8.53E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:6.26|P-value:1.25E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.29|P-value:7.35E-14 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.91|P-value:2.49E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.09|P-value:2.91E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.50|P-value:3.10E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.63|P-value:5.55E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.68|P-value:2.09E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.09|P-value:1.37E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.77|P-value:3.99E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.71|P-value:4.42E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:8.04|P-value:3.84E-13 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.69|P-value:1.99E-7 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.65|P-value:1.55E-9 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.98|P-value:1.97E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.52|P-value:7.81E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.07|P-value:1.44E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-4.17|P-value:9.34E-5 ID:SGTC_1620|Compound:st003704|FD-Score:4.39|P-value:4.63E-5 ID:SGTC_1655|Compound:st012546|FD-Score:4.48|P-value:3.39E-5 ID:SGTC_1707|Compound:st032323|FD-Score:6.17|P-value:1.96E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:4.50|P-value:3.05E-5 ID:SGTC_1813|Compound:st051246|FD-Score:5.00|P-value:4.25E-6 ID:SGTC_1845|Compound:st056753|FD-Score:5.34|P-value:1.00E-6 ID:SGTC_1846|Compound:st056244|FD-Score:4.44|P-value:3.83E-5 ID:SGTC_1849|Compound:st056239|FD-Score:4.06|P-value:1.51E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.39|P-value:4.72E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.69|P-value:5.13E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.02|P-value:1.73E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.67|P-value:5.49E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.63|P-value:5.61E-4 ID:SGTC_2088|Compound:5278280|FD-Score:5.64|P-value:2.54E-7 ID:SGTC_2192|Compound:5915882|FD-Score:4.19|P-value:9.48E-5 ID:SGTC_2200|Compound:6600604|FD-Score:4.32|P-value:5.95E-5 ID:SGTC_2204|Compound:7233102|FD-Score:5.27|P-value:1.34E-6 ID:SGTC_2360|Compound:9040895|FD-Score:6.23|P-value:1.39E-8 ID:SGTC_2381|Compound:9035592|FD-Score:3.61|P-value:6.56E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.24|P-value:8.16E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.61|P-value:6.64E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.14|P-value:1.16E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.88|P-value:2.49E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.00|P-value:2.26E-10 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-14.60|P-value:2.66E-39 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.85|P-value:7.74E-6 ID:SGTC_2671|Compound:danthron|FD-Score:5.86|P-value:8.91E-8 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.11|P-value:1.28E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.40|P-value:4.57E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.82|P-value:3.36E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.54|P-value:8.28E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.78|P-value:9.10E-6 ID:SGTC_3012|Compound:9080433|FD-Score:-4.10|P-value:1.17E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.90|P-value:6.42E-6 ID:SGTC_3050|Compound:9093513|FD-Score:4.22|P-value:8.59E-5 ID:SGTC_3247|Compound:9135149|FD-Score:6.13|P-value:2.30E-8 ID:SGTC_3254|Compound:9136651|FD-Score:6.97|P-value:2.62E-10 ID:SGTC_3330|Compound:9141424|FD-Score:4.45|P-value:3.74E-5

Top fitness defect scores for YER095W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 8.29 424.9 nM 7.35E-14 DNA damage response 11 5.76E-17
2 SGTC_1309 pyrazolanthrone 8.04 13.4 µM 3.84E-13 4 4.56E-16
3 SGTC_720 r052-1644 7.09 49.9 µM 1.34E-10 TSC3-RPN4 4 6.87E-13
4 SGTC_2612 dictamnine 7.00 15.5 µM 2.26E-10 RNA pol III & RNase P/MRP 8 1.33E-12
5 SGTC_3254 9136651 6.97 49.5 µM 2.62E-10 DNA damage response 3 1.59E-12
6 SGTC_1369 1866-0067 6.65 208.0 µM 1.55E-9 RPP1 & pyrimidine depletion 8 1.47E-11
7 SGTC_73 0327-0325 6.64 16.2 µM 1.66E-9 DNA damage response 10 1.61E-11
8 SGTC_1079 idarubicin 6.26 2.4 µM 1.25E-8 DNA damage response 6 1.99E-10
9 SGTC_2360 9040895 6.23 200.0 µM 1.39E-8 RPP1 & pyrimidine depletion 4 2.28E-10
10 SGTC_1707 st032323 6.17 6.3 µM 1.96E-8 DNA damage response 20 3.49E-10
11 SGTC_3247 9135149 6.13 49.5 µM 2.30E-8 DNA damage response 11 4.27E-10
12 SGTC_238 5hr heat shock (37°C) + nsc-638432 6.05 8.9 µM 3.56E-8 heat shock/prefoldin 15 7.38E-10
13 SGTC_93 0109-0045 5.93 59.2 µM 6.22E-8 DNA damage response 11 1.48E-9
14 SGTC_2671 danthron 5.86 100.0 µM 8.91E-8 DNA damage response 14 2.31E-9
15 SGTC_840 0245-0196 5.81 390.0 µM 1.12E-7 1 3.09E-9
16 SGTC_829 1635-0120 5.70 117.0 µM 1.93E-7 DNA damage response 11 6.08E-9
17 SGTC_1336 1486-0901 5.69 104.0 µM 1.99E-7 8 6.32E-9
18 SGTC_1173 0443-0020 5.68 122.0 µM 2.09E-7 TSC3-RPN4 12 6.71E-9
19 SGTC_2088 5278280 5.64 127.4 µM 2.54E-7 5 8.56E-9
20 SGTC_58 0957-0393 5.59 9.0 µM 3.16E-7 cell wall 237 1.12E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.382 1.07E-116 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.360 2.32E-103 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.353 2.48E-99 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.307 5.39E-74 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.252 7.51E-50 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.247 7.55E-48 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.246 2.04E-47 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.244 1.43E-46 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.235 3.54E-43 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.231 8.18E-42 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.218 1.92E-37 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.194 6.98E-30 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.193 2.01E-29 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
0.185 4.04E-27 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.183 9.41E-27 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21