YER096W / SHC1

Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER096W / SHC1

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:4.09|P-value:2.90E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.89|P-value:5.67E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:3.28|P-value:6.27E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.36|P-value:4.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.33|P-value:4.76E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.19|P-value:8.79E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.23|P-value:7.48E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.66|P-value:1.62E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:7.29|P-value:3.48E-13 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.33|P-value:5.38E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.40|P-value:4.18E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.29|P-value:6.16E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.14|P-value:8.88E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.37|P-value:4.71E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.41|P-value:3.55E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.44|P-value:3.69E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.77|P-value:9.03E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.31|P-value:5.78E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.73|P-value:1.23E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.17|P-value:9.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:5.10|P-value:2.63E-7 ID:SGTC_1672|Compound:st016598|FD-Score:4.73|P-value:1.62E-6 ID:SGTC_1710|Compound:st031758|FD-Score:3.28|P-value:6.40E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.75|P-value:7.63E-9 ID:SGTC_1838|Compound:st055369|FD-Score:3.18|P-value:9.07E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.24|P-value:6.37E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.21|P-value:8.23E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.46|P-value:3.41E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.41|P-value:4.04E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.46|P-value:3.37E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.79|P-value:8.34E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.99|P-value:4.59E-7 ID:SGTC_2273|Compound:7815444|FD-Score:3.90|P-value:6.33E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.43|P-value:3.77E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.48|P-value:3.14E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.25|P-value:7.14E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.73|P-value:1.25E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.45|P-value:3.08E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.61|P-value:1.97E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.32|P-value:5.64E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.66|P-value:2.26E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.35|P-value:5.03E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.84|P-value:4.46E-9 ID:SGTC_2819|Compound:7996655|FD-Score:4.14|P-value:2.37E-5 ID:SGTC_2870|Compound:9038528|FD-Score:-3.36|P-value:4.25E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.92|P-value:5.73E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.19|P-value:8.78E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.19|P-value:1.61E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.21|P-value:7.08E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.43|P-value:6.62E-6 ID:SGTC_3121|Compound:9125696|FD-Score:3.83|P-value:8.28E-5 ID:SGTC_3122|Compound:9126309|FD-Score:3.44|P-value:3.64E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.24|P-value:7.25E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.09|P-value:2.90E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.89|P-value:5.67E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:3.28|P-value:6.27E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.36|P-value:4.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.33|P-value:4.76E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.19|P-value:8.79E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.23|P-value:7.48E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.66|P-value:1.62E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:7.29|P-value:3.48E-13 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.33|P-value:5.38E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.40|P-value:4.18E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.29|P-value:6.16E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.14|P-value:8.88E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.37|P-value:4.71E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.41|P-value:3.55E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.44|P-value:3.69E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.77|P-value:9.03E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.31|P-value:5.78E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.73|P-value:1.23E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.17|P-value:9.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:5.10|P-value:2.63E-7 ID:SGTC_1672|Compound:st016598|FD-Score:4.73|P-value:1.62E-6 ID:SGTC_1710|Compound:st031758|FD-Score:3.28|P-value:6.40E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.75|P-value:7.63E-9 ID:SGTC_1838|Compound:st055369|FD-Score:3.18|P-value:9.07E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.24|P-value:6.37E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.21|P-value:8.23E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.46|P-value:3.41E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.41|P-value:4.04E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.46|P-value:3.37E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.79|P-value:8.34E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.99|P-value:4.59E-7 ID:SGTC_2273|Compound:7815444|FD-Score:3.90|P-value:6.33E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.43|P-value:3.77E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.48|P-value:3.14E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.25|P-value:7.14E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.73|P-value:1.25E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.45|P-value:3.08E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.61|P-value:1.97E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.32|P-value:5.64E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.66|P-value:2.26E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.35|P-value:5.03E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.84|P-value:4.46E-9 ID:SGTC_2819|Compound:7996655|FD-Score:4.14|P-value:2.37E-5 ID:SGTC_2870|Compound:9038528|FD-Score:-3.36|P-value:4.25E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.92|P-value:5.73E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.19|P-value:8.78E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.19|P-value:1.61E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.21|P-value:7.08E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.43|P-value:6.62E-6 ID:SGTC_3121|Compound:9125696|FD-Score:3.83|P-value:8.28E-5 ID:SGTC_3122|Compound:9126309|FD-Score:3.44|P-value:3.64E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.24|P-value:7.25E-4

Top fitness defect scores for YER096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_977 1348-1378 7.29 135.0 µM 3.48E-13 2 1.59E-13
2 SGTC_2802 7925815 5.84 54.5 µM 4.46E-9 7 2.62E-9
3 SGTC_1738 st035555 5.75 74.0 µM 7.63E-9 TSC3-RPN4 7 4.55E-9
4 SGTC_1648 st011736 5.10 69.8 µM 2.63E-7 PDR1 3 1.73E-7
5 SGTC_2179 6298986 4.99 200.0 µM 4.59E-7 heme requiring 7 3.06E-7
6 SGTC_1672 st016598 4.73 6.5 µM 1.62E-6 endomembrane recycling 47 1.12E-6
7 SGTC_2600 tangeritin 4.66 88.0 µM 2.26E-6 16 1.57E-6
8 SGTC_3078 9116413 4.43 49.5 µM 6.62E-6 unfolded protein response 26 4.75E-6
9 SGTC_1099 5-nonyloxytryptamine 4.21 2.9 µM 1.70E-5 14 1.25E-5
10 SGTC_2819 7996655 4.14 46.4 µM 2.37E-5 19 1.76E-5
11 SGTC_152 4469-0003 4.09 551.2 µM 2.90E-5 22 2.17E-5
12 SGTC_2965 9082772 3.92 38.6 µM 5.73E-5 mitochondrial response to ROS 42 4.36E-5
13 SGTC_2273 7815444 3.90 169.1 µM 6.33E-5 24 4.83E-5
14 SGTC_3121 9125696 3.83 49.5 µM 8.28E-5 4 6.37E-5
15 SGTC_1625 st003711 3.73 30.1 µM 1.23E-4 calcium & mitochondrial duress 44 9.56E-5
16 SGTC_2569 tetrandrine 3.73 100.0 µM 1.25E-4 27 9.74E-5
17 SGTC_2172 5754775 3.72 163.9 µM 1.29E-4 19 1.01E-4
18 SGTC_781 4335-2806 3.66 94.4 µM 1.62E-4 28 1.27E-4
19 SGTC_2594 a-mangostin 3.61 100.0 µM 1.97E-4 39 1.55E-4
20 SGTC_2422 chlorphenesin carbamate 3.48 384.2 µM 3.14E-4 47 2.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.15E-10 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.100 5.93E-9 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.18E-7 YKL192C ACP1 het Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
0.082 1.77E-6 YGL228W SHE10 hom Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
0.079 4.82E-6 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.078 5.77E-6 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.075 1.53E-5 YKR090W PXL1 hom Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.070 5.55E-5 YLR299W ECM38 hom Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
0.069 5.92E-5 YJL047C-A_p YJL047C-A_p hom Putative protein of unknown function
0.069 6.88E-5 YHR060W VMA22 hom Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
0.067 1.10E-4 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.066 1.30E-4 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.066 1.36E-4 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.064 2.03E-4 YOR217W RFC1 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.064 2.24E-4 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)