YER097W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YER097W / YER097W

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:4.25|P-value:5.12E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.35|P-value:6.62E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.94|P-value:2.35E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:3.77|P-value:2.89E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.72|P-value:1.86E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.69|P-value:2.08E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.85|P-value:2.23E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.90|P-value:3.43E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.73|P-value:3.36E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:5.16|P-value:1.09E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:5.14|P-value:1.17E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:5.06|P-value:1.72E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:4.14|P-value:7.71E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.89|P-value:1.95E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.04|P-value:1.13E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.83|P-value:4.18E-8 ID:SGTC_1124|Compound:fisetin|FD-Score:3.53|P-value:6.62E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.59|P-value:5.38E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.56|P-value:5.93E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.63|P-value:1.13E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.48|P-value:7.79E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.73|P-value:3.32E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.58|P-value:1.39E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.47|P-value:8.04E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.84|P-value:2.31E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.07|P-value:1.01E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.33|P-value:6.94E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.46|P-value:8.11E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.15|P-value:7.34E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.54|P-value:3.45E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.45|P-value:2.31E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:6.92|P-value:8.88E-11 ID:SGTC_2601|Compound:securinine|FD-Score:4.31|P-value:4.03E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.34|P-value:4.65E-7 ID:SGTC_2657|Compound:nystatin|FD-Score:5.03|P-value:1.95E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.48|P-value:7.82E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.70|P-value:3.76E-4 ID:SGTC_2849|Compound:9019321|FD-Score:9.06|P-value:2.59E-17 ID:SGTC_2854|Compound:9024559|FD-Score:3.66|P-value:4.20E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.58|P-value:5.57E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.72|P-value:1.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.42|P-value:2.65E-5 ID:SGTC_3019|Compound:9081971|FD-Score:4.95|P-value:2.87E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.80|P-value:2.65E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.56|P-value:5.98E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-3.31|P-value:7.38E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.13|P-value:8.02E-5 ID:SGTC_3155|Compound:9099265|FD-Score:4.20|P-value:6.10E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.89|P-value:1.02E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.02|P-value:6.08E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:4.25|P-value:5.12E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.35|P-value:6.62E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.94|P-value:2.35E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:3.77|P-value:2.89E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.72|P-value:1.86E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.69|P-value:2.08E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.85|P-value:2.23E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.90|P-value:3.43E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.73|P-value:3.36E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:5.16|P-value:1.09E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:5.14|P-value:1.17E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:5.06|P-value:1.72E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:4.14|P-value:7.71E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.89|P-value:1.95E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.04|P-value:1.13E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.83|P-value:4.18E-8 ID:SGTC_1124|Compound:fisetin|FD-Score:3.53|P-value:6.62E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.59|P-value:5.38E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.56|P-value:5.93E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.63|P-value:1.13E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.48|P-value:7.79E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.73|P-value:3.32E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.58|P-value:1.39E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.47|P-value:8.04E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.84|P-value:2.31E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.07|P-value:1.01E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.33|P-value:6.94E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.46|P-value:8.11E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.15|P-value:7.34E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.54|P-value:3.45E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.45|P-value:2.31E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:6.92|P-value:8.88E-11 ID:SGTC_2601|Compound:securinine|FD-Score:4.31|P-value:4.03E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.34|P-value:4.65E-7 ID:SGTC_2657|Compound:nystatin|FD-Score:5.03|P-value:1.95E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.48|P-value:7.82E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.70|P-value:3.76E-4 ID:SGTC_2849|Compound:9019321|FD-Score:9.06|P-value:2.59E-17 ID:SGTC_2854|Compound:9024559|FD-Score:3.66|P-value:4.20E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.58|P-value:5.57E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.72|P-value:1.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.42|P-value:2.65E-5 ID:SGTC_3019|Compound:9081971|FD-Score:4.95|P-value:2.87E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.80|P-value:2.65E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.56|P-value:5.98E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-3.31|P-value:7.38E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.13|P-value:8.02E-5 ID:SGTC_3155|Compound:9099265|FD-Score:4.20|P-value:6.10E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.89|P-value:1.02E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.02|P-value:6.08E-5

Top fitness defect scores for YER097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2849 9019321 9.06 13.0 µM 2.59E-17 2 6.30E-20
2 SGTC_2598 perillyl alcohol 6.92 100.0 µM 8.88E-11 3 2.27E-12
3 SGTC_145 3737-0113 5.94 38.4 µM 2.35E-8 DNA intercalators 29 1.45E-9
4 SGTC_1032 k061-1018 5.83 98.7 µM 4.18E-8 3 2.82E-9
5 SGTC_2633 5,7-dihydroxyisoflavone 5.34 100.0 µM 4.65E-7 13 4.60E-8
6 SGTC_735 3076-0345 5.16 636.0 µM 1.09E-6 9 1.24E-7
7 SGTC_755 1995-0008 5.14 37.3 µM 1.17E-6 11 1.35E-7
8 SGTC_764 1951-2361 5.06 146.0 µM 1.72E-6 17 2.09E-7
9 SGTC_2657 nystatin 5.03 74.4 µM 1.95E-6 4 2.42E-7
10 SGTC_3019 9081971 4.95 49.5 µM 2.87E-6 7 3.80E-7
11 SGTC_534 k292-0788 4.90 63.4 µM 3.43E-6 mitochondrial processes 10 4.67E-7
12 SGTC_1359 1582-0056 4.63 520.0 nM 1.13E-5 9 1.86E-6
13 SGTC_1719 st032227 4.58 49.2 µM 1.39E-5 14 2.38E-6
14 SGTC_2595 hexamethylquercetagetin 4.45 100.0 µM 2.31E-5 16 4.26E-6
15 SGTC_2937 9044753 4.42 11.3 µM 2.65E-5 60S ribosome export 24 5.00E-6
16 SGTC_2601 securinine 4.31 100.0 µM 4.03E-5 24 8.14E-6
17 SGTC_62 0180-0423 4.25 3.2 µM 5.12E-5 60S ribosome export 12 1.08E-5
18 SGTC_3155 9099265 4.20 49.5 µM 6.10E-5 20 1.32E-5
19 SGTC_2067 5224629 4.15 34.1 µM 7.34E-5 21 1.63E-5
20 SGTC_886 0866-0150 4.14 153.0 µM 7.71E-5 19 1.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.21E-14 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.110 2.05E-10 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.22E-9 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.101 5.39E-9 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.48E-8 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.096 2.98E-8 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.091 1.19E-7 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.089 2.36E-7 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.087 4.80E-7 YNR043W MVD1 het Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
0.084 9.75E-7 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.084 1.13E-6 YBR014C GRX7 hom Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication
0.084 1.15E-6 YDL142C CRD1 hom Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis
0.084 1.23E-6 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.083 1.45E-6 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.083 1.72E-6 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters