YER098W / UBP9

Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER098W / UBP9

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.33|P-value:8.25E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.05|P-value:6.48E-5 ID:SGTC_224|Compound:benfluorex|FD-Score:4.29|P-value:2.47E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.52|P-value:4.03E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.56|P-value:8.12E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.82|P-value:2.53E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.58|P-value:3.63E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.32|P-value:2.17E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:6.00|P-value:6.64E-9 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.91|P-value:1.00E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.54|P-value:4.07E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:4.87|P-value:2.00E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:4.63|P-value:5.92E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.33|P-value:7.63E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.36|P-value:7.38E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.67|P-value:5.06E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.73|P-value:2.11E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.40|P-value:1.56E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.27|P-value:2.67E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.55|P-value:3.63E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.47|P-value:1.11E-7 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.95|P-value:1.41E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.49|P-value:4.78E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.00|P-value:7.82E-5 ID:SGTC_1523|Compound:st012844|FD-Score:4.05|P-value:6.37E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.05|P-value:6.39E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.44|P-value:5.70E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.69|P-value:2.41E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.23|P-value:3.15E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.44|P-value:1.34E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.36|P-value:7.54E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.83|P-value:1.36E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.01|P-value:7.51E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.94|P-value:9.80E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.61|P-value:3.21E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.46|P-value:5.38E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.47|P-value:5.17E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:4.25|P-value:2.95E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.80|P-value:2.82E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.61|P-value:3.26E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.31|P-value:2.32E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.06|P-value:6.06E-5 ID:SGTC_3089|Compound:9117425|FD-Score:4.17|P-value:4.05E-5 ID:SGTC_3093|Compound:9117344|FD-Score:-3.83|P-value:1.36E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.58|P-value:3.32E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.31|P-value:8.11E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.38|P-value:6.53E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.44|P-value:5.79E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.57|P-value:3.41E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.34|P-value:7.96E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.33|P-value:8.25E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.05|P-value:6.48E-5 ID:SGTC_224|Compound:benfluorex|FD-Score:4.29|P-value:2.47E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.52|P-value:4.03E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.56|P-value:8.12E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.82|P-value:2.53E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.58|P-value:3.63E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.32|P-value:2.17E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:6.00|P-value:6.64E-9 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.91|P-value:1.00E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.54|P-value:4.07E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:4.87|P-value:2.00E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:4.63|P-value:5.92E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.33|P-value:7.63E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.36|P-value:7.38E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.67|P-value:5.06E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.73|P-value:2.11E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.40|P-value:1.56E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.27|P-value:2.67E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.55|P-value:3.63E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.47|P-value:1.11E-7 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.95|P-value:1.41E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.49|P-value:4.78E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.00|P-value:7.82E-5 ID:SGTC_1523|Compound:st012844|FD-Score:4.05|P-value:6.37E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.05|P-value:6.39E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.44|P-value:5.70E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.69|P-value:2.41E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.23|P-value:3.15E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.44|P-value:1.34E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.36|P-value:7.54E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.83|P-value:1.36E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.01|P-value:7.51E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.94|P-value:9.80E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.61|P-value:3.21E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.46|P-value:5.38E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.47|P-value:5.17E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:4.25|P-value:2.95E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.80|P-value:2.82E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.61|P-value:3.26E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.31|P-value:2.32E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.06|P-value:6.06E-5 ID:SGTC_3089|Compound:9117425|FD-Score:4.17|P-value:4.05E-5 ID:SGTC_3093|Compound:9117344|FD-Score:-3.83|P-value:1.36E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.58|P-value:3.32E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.31|P-value:8.11E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.38|P-value:6.53E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.44|P-value:5.79E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.57|P-value:3.41E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.34|P-value:7.96E-4

Top fitness defect scores for YER098W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_541 4513-1321 6.00 94.0 µM 6.64E-9 4 9.66E-10
2 SGTC_1383 3049-0032 5.47 20.7 µM 1.11E-7 60S ribosome export 4 2.20E-8
3 SGTC_1399 3562-5772 4.95 25.0 µM 1.41E-6 RPP1 & pyrimidine depletion 6 3.72E-7
4 SGTC_732 3970-1727 4.87 52.7 µM 2.00E-6 4 5.47E-7
5 SGTC_410 α-linolenic acid 4.82 100.0 µM 2.53E-6 excess fatty acid 19 7.10E-7
6 SGTC_2649 anisomycin 4.80 9.6 µM 2.82E-6 3 8.00E-7
7 SGTC_1026 k007-1105 4.67 30.6 µM 5.06E-6 ERAD & cell cycle 71 1.53E-6
8 SGTC_756 0508-1999 4.63 28.3 µM 5.92E-6 RPP1 & pyrimidine depletion 11 1.82E-6
9 SGTC_409 arachidonic acid 4.56 100.0 µM 8.12E-6 13 2.59E-6
10 SGTC_1824 st053723 4.44 68.6 µM 1.34E-5 20 4.52E-6
11 SGTC_1130 3454-2858 4.40 15.9 µM 1.56E-5 NEO1 66 5.35E-6
12 SGTC_533 1222-0222 4.32 6.7 µM 2.17E-5 PDR1 21 7.72E-6
13 SGTC_2952 9073731 4.31 13.8 µM 2.32E-5 tubulin folding & SWR complex 32 8.29E-6
14 SGTC_224 benfluorex 4.29 43.9 µM 2.47E-5 3 8.90E-6
15 SGTC_1179 1021-1431 4.27 9.3 µM 2.67E-5 32 9.70E-6
16 SGTC_2642 cholecalciferol 4.25 100.0 µM 2.95E-5 18 1.08E-5
17 SGTC_1796 st049173 4.23 110.4 µM 3.15E-5 11 1.17E-5
18 SGTC_3089 9117425 4.17 49.5 µM 4.05E-5 17 1.54E-5
19 SGTC_2970 9090938 4.06 41.9 µM 6.06E-5 RNA processing & uracil transport 34 2.41E-5
20 SGTC_1523 st012844 4.05 44.7 µM 6.37E-5 60S ribosome export 17 2.54E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.03E-8 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.088 2.89E-7 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.084 9.64E-7 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.081 2.41E-6 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.079 5.29E-6 YGL190C CDC55 hom Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion
0.077 7.26E-6 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.074 1.97E-5 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.074 1.99E-5 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.070 5.01E-5 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.069 5.85E-5 YIL091C UTP25 het Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis
0.069 6.82E-5 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.068 8.75E-5 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.067 1.04E-4 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.067 1.08E-4 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.067 1.12E-4 YBR297W MAL33 hom MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C