YER103W / SSA4

Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER103W / SSA4

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.26|P-value:2.33E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.60|P-value:5.46E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.66|P-value:4.29E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.90|P-value:1.39E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:4.16|P-value:3.93E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.57|P-value:6.34E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.19|P-value:3.37E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.75|P-value:2.89E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.11|P-value:4.16E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.60|P-value:5.58E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:4.80|P-value:1.29E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:2.91|P-value:9.02E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:2.99|P-value:6.73E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.50|P-value:8.58E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.19|P-value:3.06E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.25|P-value:2.39E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.38|P-value:1.44E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.57|P-value:4.75E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.21|P-value:2.82E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.07|P-value:4.83E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.15|P-value:3.61E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.20|P-value:2.87E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-2.92|P-value:8.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_1676|Compound:st018489|FD-Score:2.89|P-value:9.66E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.19|P-value:3.10E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.89|P-value:1.47E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-2.87|P-value:9.98E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.01|P-value:6.17E-4 ID:SGTC_1912|Compound:st060209|FD-Score:2.90|P-value:9.25E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.85|P-value:1.78E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-2.97|P-value:7.08E-4 ID:SGTC_1954|Compound:st077032|FD-Score:6.18|P-value:1.62E-11 ID:SGTC_1982|Compound:st072467|FD-Score:4.99|P-value:4.21E-8 ID:SGTC_1993|Compound:st073995|FD-Score:-3.01|P-value:6.16E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.64|P-value:4.64E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.64|P-value:4.66E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.23|P-value:2.68E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.47|P-value:9.91E-5 ID:SGTC_2264|Compound:7948757|FD-Score:5.47|P-value:2.14E-9 ID:SGTC_2267|Compound:7931562|FD-Score:3.09|P-value:4.52E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.67|P-value:2.72E-7 ID:SGTC_2274|Compound:7947094|FD-Score:5.41|P-value:3.24E-9 ID:SGTC_2314|Compound:7727897|FD-Score:-3.30|P-value:1.93E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.01|P-value:6.12E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.31|P-value:1.85E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.12|P-value:4.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.48|P-value:7.67E-7 ID:SGTC_2925|Compound:9010536|FD-Score:-3.37|P-value:1.45E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.18|P-value:3.25E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.77|P-value:2.83E-10 ID:SGTC_2941|Compound:9056145|FD-Score:2.96|P-value:7.42E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.66|P-value:4.22E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.26|P-value:2.36E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.92|P-value:1.25E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.48|P-value:9.26E-5 ID:SGTC_3269|Compound:9137823|FD-Score:4.70|P-value:2.32E-7 ID:SGTC_3278|Compound:9139605|FD-Score:3.81|P-value:2.16E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.26|P-value:2.33E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.60|P-value:5.46E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.66|P-value:4.29E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.90|P-value:1.39E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:4.16|P-value:3.93E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.57|P-value:6.34E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.19|P-value:3.37E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.75|P-value:2.89E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.11|P-value:4.16E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.60|P-value:5.58E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:4.80|P-value:1.29E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:2.91|P-value:9.02E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:2.99|P-value:6.73E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.50|P-value:8.58E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.19|P-value:3.06E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.25|P-value:2.39E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.38|P-value:1.44E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.57|P-value:4.75E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.21|P-value:2.82E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.07|P-value:4.83E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.15|P-value:3.61E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.20|P-value:2.87E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-2.92|P-value:8.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_1676|Compound:st018489|FD-Score:2.89|P-value:9.66E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.19|P-value:3.10E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.89|P-value:1.47E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-2.87|P-value:9.98E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.01|P-value:6.17E-4 ID:SGTC_1912|Compound:st060209|FD-Score:2.90|P-value:9.25E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.85|P-value:1.78E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-2.97|P-value:7.08E-4 ID:SGTC_1954|Compound:st077032|FD-Score:6.18|P-value:1.62E-11 ID:SGTC_1982|Compound:st072467|FD-Score:4.99|P-value:4.21E-8 ID:SGTC_1993|Compound:st073995|FD-Score:-3.01|P-value:6.16E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.64|P-value:4.64E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.64|P-value:4.66E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.23|P-value:2.68E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.47|P-value:9.91E-5 ID:SGTC_2264|Compound:7948757|FD-Score:5.47|P-value:2.14E-9 ID:SGTC_2267|Compound:7931562|FD-Score:3.09|P-value:4.52E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.67|P-value:2.72E-7 ID:SGTC_2274|Compound:7947094|FD-Score:5.41|P-value:3.24E-9 ID:SGTC_2314|Compound:7727897|FD-Score:-3.30|P-value:1.93E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.01|P-value:6.12E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.31|P-value:1.85E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.12|P-value:4.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.48|P-value:7.67E-7 ID:SGTC_2925|Compound:9010536|FD-Score:-3.37|P-value:1.45E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.18|P-value:3.25E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.77|P-value:2.83E-10 ID:SGTC_2941|Compound:9056145|FD-Score:2.96|P-value:7.42E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.66|P-value:4.22E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.26|P-value:2.36E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.92|P-value:1.25E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.48|P-value:9.26E-5 ID:SGTC_3269|Compound:9137823|FD-Score:4.70|P-value:2.32E-7 ID:SGTC_3278|Compound:9139605|FD-Score:3.81|P-value:2.16E-5

Top fitness defect scores for YER103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1954 st077032 6.18 68.9 µM 1.62E-11 1 3.21E-10
2 SGTC_2937 9044753 5.77 11.3 µM 2.83E-10 60S ribosome export 8 3.85E-9
3 SGTC_2264 7948757 5.47 110.8 µM 2.14E-9 3 2.25E-8
4 SGTC_2274 7947094 5.41 46.1 µM 3.24E-9 7 3.22E-8
5 SGTC_1982 st072467 4.99 71.9 µM 4.21E-8 13 3.01E-7
6 SGTC_804 1595-0054 4.80 20.9 µM 1.29E-7 sphingolipid biosynthesis & PDR1 21 7.97E-7
7 SGTC_3269 9137823 4.70 49.5 µM 2.32E-7 60S ribosome export 7 1.33E-6
8 SGTC_2268 7933382 4.67 153.8 µM 2.72E-7 20 1.53E-6
9 SGTC_1166 k206-0078 4.57 225.0 µM 4.75E-7 9 2.49E-6
10 SGTC_2788 5282734 4.48 71.4 µM 7.67E-7 27 3.77E-6
11 SGTC_574 1315-0397 4.19 40.0 µM 3.37E-6 26 1.37E-5
12 SGTC_523 1934-0222 4.16 13.7 µM 3.93E-6 29 1.57E-5
13 SGTC_518 1021-0119 3.90 62.6 µM 1.39E-5 ERG2 39 4.72E-5
14 SGTC_1774 st048371 3.89 48.5 µM 1.47E-5 RNA processing & uracil transport 17 4.97E-5
15 SGTC_1939 st074455 3.85 53.6 µM 1.78E-5 31 5.85E-5
16 SGTC_3278 9139605 3.81 49.5 µM 2.16E-5 18 6.95E-5
17 SGTC_648 0375-0473 3.75 33.3 µM 2.89E-5 21 8.96E-5
18 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.66 150.0 µM 4.29E-5 Golgi 49 1.26E-4
19 SGTC_2049 5262831 3.64 67.2 µM 4.66E-5 38 1.36E-4
20 SGTC_479 n-linoleoylglycine 3.60 10.0 µM 5.46E-5 16 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 9.18E-8 YLR010C TEN1 het Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
0.087 3.85E-7 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.086 6.67E-7 YDR538W PAD1 hom Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
0.079 4.09E-6 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.075 1.38E-5 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.075 1.51E-5 YAR047C_d YAR047C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.074 1.99E-5 YPR075C OPY2 hom Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress
0.073 2.08E-5 YMR224C MRE11 hom Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
0.073 2.23E-5 YOR337W TEA1 hom Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
0.073 2.45E-5 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.072 3.12E-5 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.072 3.29E-5 YBR242W_p YBR242W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
0.070 5.44E-5 YDR468C TLG1 het Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
0.070 5.48E-5 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.069 6.75E-5 YNL226W_d YNL226W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C