YER104W / RTT105

Protein with a role in regulation of Ty1 transposition

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER104W / RTT105

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.35|P-value:8.79E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:9.16|P-value:6.58E-18 ID:SGTC_89|Compound:0302-0250|FD-Score:3.33|P-value:9.18E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.40|P-value:7.44E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-6.89|P-value:7.61E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.89|P-value:7.71E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:3.32|P-value:9.45E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.10|P-value:6.48E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.22|P-value:4.06E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.71|P-value:2.61E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.63|P-value:3.43E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.04|P-value:8.06E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.70|P-value:5.67E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.33|P-value:9.16E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.49|P-value:6.18E-4 ID:SGTC_1794|Compound:st048918|FD-Score:-3.44|P-value:7.09E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.37|P-value:8.00E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.43|P-value:6.79E-4 ID:SGTC_2004|Compound:4023728|FD-Score:5.78|P-value:3.45E-8 ID:SGTC_2008|Compound:4012253|FD-Score:5.56|P-value:1.06E-7 ID:SGTC_2146|Compound:5545642|FD-Score:-5.84|P-value:3.02E-8 ID:SGTC_2255|Compound:7941087|FD-Score:3.88|P-value:1.43E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.44|P-value:7.08E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.50|P-value:5.81E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-4.30|P-value:3.37E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.72|P-value:2.85E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:7.73|P-value:2.72E-13 ID:SGTC_2532|Compound:xanthone|FD-Score:3.92|P-value:1.25E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.13|P-value:5.59E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.23|P-value:4.40E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:6.05|P-value:8.24E-9 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.07|P-value:1.11E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.36|P-value:8.46E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.57|P-value:4.24E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.35|P-value:8.75E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.48|P-value:1.61E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.39|P-value:7.70E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.68|P-value:2.94E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.35|P-value:8.79E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:9.16|P-value:6.58E-18 ID:SGTC_89|Compound:0302-0250|FD-Score:3.33|P-value:9.18E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.40|P-value:7.44E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-6.89|P-value:7.61E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.89|P-value:7.71E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:3.32|P-value:9.45E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.10|P-value:6.48E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.22|P-value:4.06E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.71|P-value:2.61E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.63|P-value:3.43E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.04|P-value:8.06E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.70|P-value:5.67E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.33|P-value:9.16E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.49|P-value:6.18E-4 ID:SGTC_1794|Compound:st048918|FD-Score:-3.44|P-value:7.09E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.37|P-value:8.00E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.43|P-value:6.79E-4 ID:SGTC_2004|Compound:4023728|FD-Score:5.78|P-value:3.45E-8 ID:SGTC_2008|Compound:4012253|FD-Score:5.56|P-value:1.06E-7 ID:SGTC_2146|Compound:5545642|FD-Score:-5.84|P-value:3.02E-8 ID:SGTC_2255|Compound:7941087|FD-Score:3.88|P-value:1.43E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.44|P-value:7.08E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.50|P-value:5.81E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-4.30|P-value:3.37E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.72|P-value:2.85E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:7.73|P-value:2.72E-13 ID:SGTC_2532|Compound:xanthone|FD-Score:3.92|P-value:1.25E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.13|P-value:5.59E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.23|P-value:4.40E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:6.05|P-value:8.24E-9 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.07|P-value:1.11E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.36|P-value:8.46E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.57|P-value:4.24E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.35|P-value:8.75E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.48|P-value:1.61E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.39|P-value:7.70E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.68|P-value:2.94E-4

Top fitness defect scores for YER104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_66 0109-0187 9.16 42.4 µM 6.58E-18 1 2.57E-20 2.62
2 SGTC_2531 methyl deoxycholate 7.73 70.1 µM 2.72E-13 1 5.21E-15 2.92
3 SGTC_2595 hexamethylquercetagetin 6.05 100.0 µM 8.24E-9 1 7.28E-10 1.61
4 SGTC_2004 4023728 5.78 41.9 µM 3.45E-8 16 3.76E-9 0.66
5 SGTC_2008 4012253 5.56 172.0 µM 1.06E-7 2 1.37E-8 0.47
6 SGTC_2634 4'-methoxyflavone 5.07 100.0 µM 1.11E-6 2 2.01E-7 0.21
7 SGTC_1205 4161-2785 4.70 76.0 µM 5.67E-6 2 1.30E-6 0.79
8 SGTC_556 4058-0063 4.22 51.5 µM 4.06E-5 2 1.23E-5 0.35
9 SGTC_2533 agelasine 4.13 13.7 µM 5.59E-5 ERG2 11 1.78E-5 0.10
10 SGTC_551 k048-0028 4.10 34.9 µM 6.48E-5 8 2.10E-5 0.41
11 SGTC_827 3253-0474 4.04 693.0 µM 8.06E-5 6 2.70E-5 0.16
12 SGTC_2532 xanthone 3.92 78.9 µM 1.25E-4 4 4.46E-5 0.47
13 SGTC_2255 7941087 3.88 197.4 µM 1.43E-4 4 5.21E-5 0.01
14 SGTC_833 3852-0053 3.87 558.0 µM 1.50E-4 5 5.46E-5 0.18
15 SGTC_717 1532-0246 3.71 73.2 µM 2.61E-4 Golgi 11 1.03E-4 0.16
16 SGTC_796 1234-0020 3.70 70.7 µM 2.67E-4 SWF1 & branched chain AA biosynthesis 9 1.06E-4 0.16
17 SGTC_3185 9108267 3.68 49.5 µM 2.94E-4 60S ribosome export 6 1.18E-4 0.09
18 SGTC_822 1487-0950 3.63 154.0 µM 3.43E-4 3 1.41E-4 0.12
19 SGTC_2705 st078069 3.57 42.8 µM 4.24E-4 4 1.79E-4 0.01
20 SGTC_1825 st052143 3.43 62.6 µM 6.79E-4 9 3.07E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.39E-13 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.119 4.52E-12 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.113 5.12E-11 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.100 6.29E-9 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.095 3.99E-8 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.090 1.83E-7 YKR086W PRP16 het DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step
0.089 2.81E-7 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.088 2.94E-7 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.087 3.98E-7 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.086 5.37E-7 YOL026C MIM1 het Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
0.084 9.95E-7 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.080 3.83E-6 YGR228W_d YGR228W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C
0.079 4.75E-6 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.078 5.69E-6 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.078 5.98E-6 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene