YER106W / MAM1

Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle

Zygosity: Homozygous strain
fixedexpanded
Profile for YER106W / MAM1

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:3.20|P-value:4.08E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:6.40|P-value:1.13E-11 ID:SGTC_134|Compound:0269-0018|FD-Score:3.96|P-value:1.77E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.76|P-value:3.36E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.16|P-value:6.93E-6 ID:SGTC_277|Compound:nystatin|FD-Score:3.06|P-value:6.95E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.15|P-value:5.02E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.12|P-value:8.37E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:6.11|P-value:8.45E-11 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.10|P-value:6.06E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.25|P-value:3.36E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.47|P-value:1.46E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:5.40|P-value:8.29E-9 ID:SGTC_704|Compound:1310-0270|FD-Score:5.21|P-value:2.65E-8 ID:SGTC_786|Compound:4544-0069|FD-Score:3.00|P-value:8.71E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.90|P-value:1.50E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.41|P-value:2.11E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.98|P-value:1.61E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.11|P-value:9.09E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.19|P-value:4.35E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.03|P-value:7.74E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.72|P-value:5.00E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.28|P-value:3.02E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.82|P-value:3.21E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.05|P-value:7.27E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.34|P-value:2.93E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.29|P-value:3.02E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.05|P-value:7.08E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.99|P-value:9.14E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.99|P-value:1.50E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.89|P-value:2.43E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.23|P-value:3.70E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.52|P-value:1.15E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.26|P-value:3.33E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.06|P-value:6.97E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.59|P-value:8.74E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.34|P-value:2.41E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.32|P-value:2.62E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.24|P-value:3.61E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.03|P-value:7.60E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.96|P-value:9.96E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.98|P-value:9.29E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:7.73|P-value:3.27E-16 ID:SGTC_2827|Compound:7993847|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.73|P-value:4.93E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.32|P-value:3.18E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.97|P-value:1.66E-5 ID:SGTC_2931|Compound:9014674|FD-Score:3.05|P-value:7.14E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.32|P-value:2.63E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.13|P-value:5.44E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.88|P-value:2.49E-5 ID:SGTC_3078|Compound:9116413|FD-Score:3.32|P-value:2.65E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.58|P-value:9.47E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.68|P-value:6.14E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.02|P-value:8.11E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.20|P-value:4.08E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:6.40|P-value:1.13E-11 ID:SGTC_134|Compound:0269-0018|FD-Score:3.96|P-value:1.77E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.76|P-value:3.36E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.16|P-value:6.93E-6 ID:SGTC_277|Compound:nystatin|FD-Score:3.06|P-value:6.95E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.15|P-value:5.02E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.12|P-value:8.37E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:6.11|P-value:8.45E-11 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.10|P-value:6.06E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.25|P-value:3.36E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.47|P-value:1.46E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:5.40|P-value:8.29E-9 ID:SGTC_704|Compound:1310-0270|FD-Score:5.21|P-value:2.65E-8 ID:SGTC_786|Compound:4544-0069|FD-Score:3.00|P-value:8.71E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.90|P-value:1.50E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.41|P-value:2.11E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.98|P-value:1.61E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.11|P-value:9.09E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.19|P-value:4.35E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.03|P-value:7.74E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.72|P-value:5.00E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.28|P-value:3.02E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.82|P-value:3.21E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.05|P-value:7.27E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.34|P-value:2.93E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.29|P-value:3.02E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.05|P-value:7.08E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.99|P-value:9.14E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.99|P-value:1.50E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.89|P-value:2.43E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.23|P-value:3.70E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.52|P-value:1.15E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.26|P-value:3.33E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.06|P-value:6.97E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.59|P-value:8.74E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.34|P-value:2.41E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.32|P-value:2.62E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.24|P-value:3.61E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.03|P-value:7.60E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.96|P-value:9.96E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.98|P-value:9.29E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:7.73|P-value:3.27E-16 ID:SGTC_2827|Compound:7993847|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.73|P-value:4.93E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.32|P-value:3.18E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.97|P-value:1.66E-5 ID:SGTC_2931|Compound:9014674|FD-Score:3.05|P-value:7.14E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.32|P-value:2.63E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.13|P-value:5.44E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.88|P-value:2.49E-5 ID:SGTC_3078|Compound:9116413|FD-Score:3.32|P-value:2.65E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.58|P-value:9.47E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.68|P-value:6.14E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.02|P-value:8.11E-4

Top fitness defect scores for YER106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2730 imipramine 7.73 71.3 µM 3.27E-16 1 5.28E-15
2 SGTC_133 0724-0033 6.40 378.9 µM 1.13E-11 6 7.73E-11
3 SGTC_517 1365-0151 6.11 113.0 µM 8.45E-11 9 4.90E-10
4 SGTC_703 3875-0075 5.40 71.8 µM 8.29E-9 4 3.30E-8
5 SGTC_704 1310-0270 5.21 142.0 µM 2.65E-8 11 9.60E-8
6 SGTC_803 4488-1585 4.90 147.0 µM 1.50E-7 2 4.72E-7
7 SGTC_231 b-estradiol 4.76 524.0 µM 3.36E-7 2 9.90E-7
8 SGTC_1936 st074407 4.52 74.3 µM 1.15E-6 DNA damage response 19 3.08E-6
9 SGTC_1506 4226-2149 4.34 212.0 µM 2.93E-6 19 7.24E-6
10 SGTC_2837 9008476 4.32 45.5 µM 3.18E-6 23 7.81E-6
11 SGTC_273 hydroxyurea 4.16 18.1 mM 6.93E-6 heme biosynthesis & mitochondrial translocase 32 1.60E-5
12 SGTC_403 arphamenine a 4.12 50.0 µM 8.37E-6 60S ribosome export 18 1.90E-5
13 SGTC_1855 st056195 3.99 39.6 µM 1.50E-5 60S ribosome export 19 3.25E-5
14 SGTC_2924 9010168 3.97 62.8 µM 1.66E-5 cell wall signaling 38 3.57E-5
15 SGTC_134 0269-0018 3.96 6.9 µM 1.77E-5 135 3.79E-5
16 SGTC_1886 st057356 3.89 49.9 µM 2.43E-5 60S ribosome export 22 5.07E-5
17 SGTC_3066 9117245 3.88 49.5 µM 2.49E-5 14 5.19E-5
18 SGTC_1202 1988-0068 3.82 29.6 µM 3.21E-5 RNA processing & uracil transport 31 6.55E-5
19 SGTC_2836 9010338 3.73 19.5 µM 4.93E-5 RPP1 & pyrimidine depletion 34 9.73E-5
20 SGTC_1151 3909-8316 3.72 15.3 µM 5.00E-5 22 9.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.70E-11 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.113 6.38E-11 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.108 3.35E-10 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.097 1.87E-8 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.090 2.07E-7 YDL200C MGT1 hom DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
0.088 3.25E-7 YKR073C_d YKR073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 3.90E-7 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.084 1.08E-6 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.084 1.20E-6 YGR111W_p YGR111W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 4.07E-6 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.077 7.40E-6 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.075 1.33E-5 YPL172C COX10 hom Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
0.074 1.77E-5 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.83E-5 YPL079W RPL21B hom Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication
0.072 3.11E-5 YGR184C UBR1 hom E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)