YER107C / GLE2

RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1

Zygosity: Homozygous strain
fixedexpanded
Profile for YER107C / GLE2

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.99|P-value:5.75E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:5.00|P-value:2.24E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.94|P-value:2.80E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:6.56|P-value:4.01E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-3.72|P-value:9.60E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.83|P-value:1.17E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:4.04|P-value:4.97E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:5.42|P-value:4.85E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:9.20|P-value:2.44E-14 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.42|P-value:1.19E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.20|P-value:2.37E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.51|P-value:3.38E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:6.68|P-value:2.39E-8 ID:SGTC_235|Compound:0330-0087|FD-Score:4.18|P-value:3.35E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.07|P-value:1.76E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.81|P-value:4.40E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.37|P-value:8.09E-10 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.75|P-value:5.34E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.76|P-value:5.14E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:4.08|P-value:4.41E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.95|P-value:6.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.95|P-value:1.95E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.27|P-value:8.57E-10 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.08|P-value:3.44E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.93|P-value:6.83E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.54|P-value:3.01E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:4.90|P-value:3.26E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.25|P-value:2.71E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:9.62|P-value:1.64E-15 ID:SGTC_639|Compound:0833-0042|FD-Score:4.17|P-value:3.41E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:6.26|P-value:1.57E-7 ID:SGTC_861|Compound:0443-0273|FD-Score:4.22|P-value:2.96E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.17|P-value:1.24E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.72|P-value:9.73E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.72|P-value:6.00E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.17|P-value:3.44E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.61|P-value:8.43E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.65|P-value:1.99E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.90|P-value:3.20E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:7.32|P-value:1.07E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:6.97|P-value:5.86E-9 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.17|P-value:1.22E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.21|P-value:1.06E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:7.40|P-value:7.15E-10 ID:SGTC_1514|Compound:1189-1591|FD-Score:7.96|P-value:3.58E-11 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.87|P-value:3.55E-5 ID:SGTC_1608|Compound:st001473|FD-Score:8.67|P-value:6.12E-13 ID:SGTC_1643|Compound:st009866|FD-Score:-4.02|P-value:4.12E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.72|P-value:5.99E-5 ID:SGTC_1740|Compound:st038286|FD-Score:4.16|P-value:3.50E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.41|P-value:6.63E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.22|P-value:1.81E-7 ID:SGTC_1901|Compound:st060216|FD-Score:4.97|P-value:2.53E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-5.02|P-value:1.54E-5 ID:SGTC_2012|Compound:4023501|FD-Score:6.13|P-value:2.77E-7 ID:SGTC_2077|Compound:5212015|FD-Score:5.91|P-value:6.75E-7 ID:SGTC_2084|Compound:5306078|FD-Score:5.28|P-value:8.23E-6 ID:SGTC_2088|Compound:5278280|FD-Score:5.59|P-value:2.51E-6 ID:SGTC_2090|Compound:5301565|FD-Score:12.50|P-value:4.14E-25 ID:SGTC_2092|Compound:5303694|FD-Score:8.71|P-value:4.94E-13 ID:SGTC_2093|Compound:5331342|FD-Score:4.66|P-value:7.18E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.85|P-value:3.79E-5 ID:SGTC_2134|Compound:5324836|FD-Score:4.59|P-value:9.14E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.98|P-value:6.04E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.43|P-value:1.55E-4 ID:SGTC_2225|Compound:6654152|FD-Score:7.29|P-value:1.25E-9 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.63|P-value:8.01E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.25|P-value:2.65E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.12|P-value:3.97E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.02|P-value:5.34E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.21|P-value:1.04E-5 ID:SGTC_2430|Compound:5571206|FD-Score:4.44|P-value:1.50E-4 ID:SGTC_2456|Compound:5770359|FD-Score:5.98|P-value:5.17E-7 ID:SGTC_2461|Compound:5755302|FD-Score:9.47|P-value:4.16E-15 ID:SGTC_2483|Compound:5729050|FD-Score:3.86|P-value:8.51E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.43|P-value:1.54E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:6.56|P-value:4.09E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.95|P-value:6.55E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.08|P-value:4.50E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.01|P-value:5.52E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-5.78|P-value:8.33E-7 ID:SGTC_2701|Compound:st077767|FD-Score:5.38|P-value:5.62E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.01|P-value:1.61E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.13|P-value:3.82E-4 ID:SGTC_2921|Compound:7974240|FD-Score:11.60|P-value:6.49E-22 ID:SGTC_2949|Compound:9072542|FD-Score:4.63|P-value:8.04E-5 ID:SGTC_3151|Compound:9099821|FD-Score:4.02|P-value:5.35E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.93|P-value:5.39E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.17|P-value:3.37E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.93|P-value:6.86E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.67|P-value:7.11E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.82|P-value:9.48E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.99|P-value:5.75E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:5.00|P-value:2.24E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.94|P-value:2.80E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:6.56|P-value:4.01E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-3.72|P-value:9.60E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.83|P-value:1.17E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:4.04|P-value:4.97E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:5.42|P-value:4.85E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:9.20|P-value:2.44E-14 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.42|P-value:1.19E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.20|P-value:2.37E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.51|P-value:3.38E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:6.68|P-value:2.39E-8 ID:SGTC_235|Compound:0330-0087|FD-Score:4.18|P-value:3.35E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.07|P-value:1.76E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.81|P-value:4.40E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.37|P-value:8.09E-10 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.75|P-value:5.34E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.76|P-value:5.14E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:4.08|P-value:4.41E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.95|P-value:6.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.95|P-value:1.95E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.27|P-value:8.57E-10 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.08|P-value:3.44E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.93|P-value:6.83E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.54|P-value:3.01E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:4.90|P-value:3.26E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.25|P-value:2.71E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:9.62|P-value:1.64E-15 ID:SGTC_639|Compound:0833-0042|FD-Score:4.17|P-value:3.41E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:6.26|P-value:1.57E-7 ID:SGTC_861|Compound:0443-0273|FD-Score:4.22|P-value:2.96E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.17|P-value:1.24E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.72|P-value:9.73E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.72|P-value:6.00E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.17|P-value:3.44E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.61|P-value:8.43E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.65|P-value:1.99E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.90|P-value:3.20E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:7.32|P-value:1.07E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:6.97|P-value:5.86E-9 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.17|P-value:1.22E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.21|P-value:1.06E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:7.40|P-value:7.15E-10 ID:SGTC_1514|Compound:1189-1591|FD-Score:7.96|P-value:3.58E-11 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.87|P-value:3.55E-5 ID:SGTC_1608|Compound:st001473|FD-Score:8.67|P-value:6.12E-13 ID:SGTC_1643|Compound:st009866|FD-Score:-4.02|P-value:4.12E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.72|P-value:5.99E-5 ID:SGTC_1740|Compound:st038286|FD-Score:4.16|P-value:3.50E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.41|P-value:6.63E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.22|P-value:1.81E-7 ID:SGTC_1901|Compound:st060216|FD-Score:4.97|P-value:2.53E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-5.02|P-value:1.54E-5 ID:SGTC_2012|Compound:4023501|FD-Score:6.13|P-value:2.77E-7 ID:SGTC_2077|Compound:5212015|FD-Score:5.91|P-value:6.75E-7 ID:SGTC_2084|Compound:5306078|FD-Score:5.28|P-value:8.23E-6 ID:SGTC_2088|Compound:5278280|FD-Score:5.59|P-value:2.51E-6 ID:SGTC_2090|Compound:5301565|FD-Score:12.50|P-value:4.14E-25 ID:SGTC_2092|Compound:5303694|FD-Score:8.71|P-value:4.94E-13 ID:SGTC_2093|Compound:5331342|FD-Score:4.66|P-value:7.18E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.85|P-value:3.79E-5 ID:SGTC_2134|Compound:5324836|FD-Score:4.59|P-value:9.14E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.98|P-value:6.04E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.43|P-value:1.55E-4 ID:SGTC_2225|Compound:6654152|FD-Score:7.29|P-value:1.25E-9 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.63|P-value:8.01E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.25|P-value:2.65E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.12|P-value:3.97E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.02|P-value:5.34E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.21|P-value:1.04E-5 ID:SGTC_2430|Compound:5571206|FD-Score:4.44|P-value:1.50E-4 ID:SGTC_2456|Compound:5770359|FD-Score:5.98|P-value:5.17E-7 ID:SGTC_2461|Compound:5755302|FD-Score:9.47|P-value:4.16E-15 ID:SGTC_2483|Compound:5729050|FD-Score:3.86|P-value:8.51E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.43|P-value:1.54E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:6.56|P-value:4.09E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.95|P-value:6.55E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.08|P-value:4.50E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.01|P-value:5.52E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-5.78|P-value:8.33E-7 ID:SGTC_2701|Compound:st077767|FD-Score:5.38|P-value:5.62E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.01|P-value:1.61E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.13|P-value:3.82E-4 ID:SGTC_2921|Compound:7974240|FD-Score:11.60|P-value:6.49E-22 ID:SGTC_2949|Compound:9072542|FD-Score:4.63|P-value:8.04E-5 ID:SGTC_3151|Compound:9099821|FD-Score:4.02|P-value:5.35E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.93|P-value:5.39E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.17|P-value:3.37E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.93|P-value:6.86E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.67|P-value:7.11E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.82|P-value:9.48E-4

Top fitness defect scores for YER107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2090 5301565 12.50 104.5 µM 4.14E-25 TSC3-RPN4 4 2.30E-36
2 SGTC_2921 7974240 11.60 10.7 µM 6.49E-22 1 1.20E-31
3 SGTC_638 3970-0837 9.62 4.1 µM 1.64E-15 5 3.39E-22
4 SGTC_2461 5755302 9.47 26.1 µM 4.16E-15 4 1.34E-21
5 SGTC_159 3970-0959 9.20 50.0 µM 2.44E-14 7 1.82E-20
6 SGTC_2092 5303694 8.71 80.7 µM 4.94E-13 TSC3-RPN4 3 1.54E-18
7 SGTC_1608 st001473 8.67 40.5 µM 6.12E-13 4 2.11E-18
8 SGTC_1514 1189-1591 7.96 158.0 µM 3.58E-11 5 8.48E-16
9 SGTC_1773 st048542 7.41 73.6 µM 6.63E-10 9 6.25E-14
10 SGTC_1509 1326-1131 7.40 80.0 µM 7.15E-10 1 6.98E-14
11 SGTC_241 5hr heat shock (37°C) + cantharidin 7.37 155.4 µM 8.09E-10 cell wall signaling 21 8.39E-14
12 SGTC_1242 0402-0103 7.32 60.1 µM 1.07E-9 5 1.27E-13
13 SGTC_2225 6654152 7.29 15.4 µM 1.25E-9 4 1.59E-13
14 SGTC_1273 0849-0096 6.97 14.1 µM 5.86E-9 RPP1 & pyrimidine depletion 2 1.55E-12
15 SGTC_59 0330-0160 6.83 1.3 µM 1.17E-8 24 4.30E-12
16 SGTC_210 3551-0445 6.68 56.8 µM 2.39E-8 21 1.23E-11
17 SGTC_52 0329-0193 6.56 875.0 nM 4.01E-8 TSC3-RPN4 6 2.62E-11
18 SGTC_2531 methyl deoxycholate 6.56 70.1 µM 4.09E-8 4 2.69E-11
19 SGTC_720 r052-1644 6.26 49.9 µM 1.57E-7 TSC3-RPN4 7 1.96E-10
20 SGTC_1877 wortmannin 6.22 25.0 µM 1.81E-7 44 2.41E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.264 1.26E-54 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.200 1.06E-31 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.199 2.05E-31 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.177 4.53E-25 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.176 8.46E-25 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.175 1.57E-24 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.165 5.87E-22 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.163 1.82E-21 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.162 4.49E-21 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.160 8.85E-21 YFR036W CDC26 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.160 1.29E-20 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.154 2.57E-19 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.154 2.96E-19 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.154 3.49E-19 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.152 6.35E-19 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2