YER109C / FLO8

Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YER109C / FLO8

Click on Significant Values for Screen Details ID:SGTC_212|Compound:3807-4682|FD-Score:4.08|P-value:3.04E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:2.89|P-value:6.88E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.36|P-value:9.69E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.23|P-value:1.72E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.63|P-value:2.75E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.61|P-value:3.25E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.21|P-value:1.54E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.70|P-value:1.17E-10 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.21|P-value:1.78E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.05|P-value:3.49E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.13|P-value:2.64E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.06|P-value:3.57E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.09|P-value:2.98E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.29|P-value:2.20E-9 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.39|P-value:8.29E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.78|P-value:1.41E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.03|P-value:3.72E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.69|P-value:2.05E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.82|P-value:1.14E-5 ID:SGTC_1530|Compound:rhein|FD-Score:-2.83|P-value:8.29E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.85|P-value:3.86E-8 ID:SGTC_1619|Compound:st003326|FD-Score:3.43|P-value:7.18E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.03|P-value:3.89E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.36|P-value:1.01E-4 ID:SGTC_1817|Compound:st052116|FD-Score:2.85|P-value:8.10E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-2.91|P-value:6.14E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.60|P-value:3.20E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-2.93|P-value:5.68E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.33|P-value:1.12E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.99|P-value:4.96E-6 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.29|P-value:1.32E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:5.48|P-value:6.25E-10 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.81|P-value:8.80E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.36|P-value:9.49E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-5.04|P-value:1.08E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.85|P-value:7.50E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.68|P-value:2.29E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-2.98|P-value:4.64E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.45|P-value:4.03E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-2.95|P-value:5.19E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.18|P-value:2.14E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.16|P-value:1.89E-6 ID:SGTC_2812|Compound:7970281|FD-Score:2.95|P-value:5.39E-4 ID:SGTC_3055|Compound:9094636|FD-Score:2.97|P-value:5.02E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.70|P-value:2.09E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.08|P-value:3.04E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:2.89|P-value:6.88E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.36|P-value:9.69E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.23|P-value:1.72E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.63|P-value:2.75E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.61|P-value:3.25E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.21|P-value:1.54E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.70|P-value:1.17E-10 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.21|P-value:1.78E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.05|P-value:3.49E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.13|P-value:2.64E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.06|P-value:3.57E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.09|P-value:2.98E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.29|P-value:2.20E-9 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.39|P-value:8.29E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.78|P-value:1.41E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.03|P-value:3.72E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.69|P-value:2.05E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.82|P-value:1.14E-5 ID:SGTC_1530|Compound:rhein|FD-Score:-2.83|P-value:8.29E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.85|P-value:3.86E-8 ID:SGTC_1619|Compound:st003326|FD-Score:3.43|P-value:7.18E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.03|P-value:3.89E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.36|P-value:1.01E-4 ID:SGTC_1817|Compound:st052116|FD-Score:2.85|P-value:8.10E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-2.91|P-value:6.14E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.60|P-value:3.20E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-2.93|P-value:5.68E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.33|P-value:1.12E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.99|P-value:4.96E-6 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.29|P-value:1.32E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:5.48|P-value:6.25E-10 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.81|P-value:8.80E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.36|P-value:9.49E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-5.04|P-value:1.08E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.85|P-value:7.50E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.68|P-value:2.29E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-2.98|P-value:4.64E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.45|P-value:4.03E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-2.95|P-value:5.19E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.18|P-value:2.14E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.16|P-value:1.89E-6 ID:SGTC_2812|Compound:7970281|FD-Score:2.95|P-value:5.39E-4 ID:SGTC_3055|Compound:9094636|FD-Score:2.97|P-value:5.02E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.70|P-value:2.09E-5

Top fitness defect scores for YER109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2493 resveratrol 5.48 26.1 µM 6.25E-10 2 2.14E-8
2 SGTC_1167 k781-0610 5.29 148.0 µM 2.20E-9 RNA processing & uracil transport 5 5.98E-8
3 SGTC_1552 6-methylflavone 4.85 10.6 µM 3.86E-8 superoxide 6 6.23E-7
4 SGTC_2620 irigenin 4.45 100.0 µM 4.03E-7 20 4.25E-6
5 SGTC_945 3381-0768 4.21 11.3 µM 1.54E-6 endomembrane recycling 28 1.28E-5
6 SGTC_212 3807-4682 4.08 38.8 µM 3.04E-6 tubulin folding & SWR complex 64 2.23E-5
7 SGTC_2491 paeonol 3.99 100.0 µM 4.96E-6 10 3.33E-5
8 SGTC_1517 deoxycholic acid methyl ester 3.82 49.2 µM 1.14E-5 12 6.58E-5
9 SGTC_1230 0170-0365 3.78 3.8 µM 1.41E-5 endomembrane recycling 75 7.88E-5
10 SGTC_3300 9124615 3.70 50.5 µM 2.09E-5 22 1.09E-4
11 SGTC_2586 curcumin 3.68 80.0 µM 2.29E-5 iron homeostasis 63 1.17E-4
12 SGTC_939 1165-0479 3.61 45.3 µM 3.25E-5 46 1.56E-4
13 SGTC_1619 st003326 3.43 88.7 µM 7.18E-5 60S ribosome export 31 3.00E-4
14 SGTC_359 0081-0058 3.36 15.9 µM 9.69E-5 60S ribosome export 76 3.83E-4
15 SGTC_1717 st033143 3.36 58.0 µM 1.01E-4 72 3.96E-4
16 SGTC_2096 5468907 3.34 200.0 µM 1.10E-4 22 4.25E-4
17 SGTC_2490 carminic acid 3.33 95.4 µM 1.12E-4 14 4.33E-4
18 SGTC_2492 derrusnin 3.29 100.0 µM 1.32E-4 15 4.94E-4
19 SGTC_784 4579-0127 3.23 173.0 µM 1.72E-4 49 6.15E-4
20 SGTC_2625 euphol 3.18 100.0 µM 2.14E-4 69 7.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 3.11E-35 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.183 8.22E-27 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.175 1.77E-24 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.161 6.94E-21 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.150 1.88E-18 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.139 6.84E-16 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.137 1.57E-15 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.131 2.60E-14 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.123 8.36E-13 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.123 8.84E-13 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 2.14E-12 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.120 2.63E-12 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.116 1.60E-11 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.113 5.00E-11 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.108 4.09E-10 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress