YER110C / KAP123

Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1

Zygosity: Homozygous strain
fixedexpanded
Profile for YER110C / KAP123

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:5.09E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.77|P-value:2.61E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.68|P-value:2.06E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.71|P-value:1.83E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.62|P-value:2.51E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.70|P-value:1.87E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:5.16|P-value:4.38E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.55|P-value:6.75E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.69|P-value:1.93E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.54|P-value:7.19E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:6.55|P-value:2.64E-10 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.36|P-value:6.02E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.62|P-value:5.45E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.24|P-value:8.90E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.58|P-value:2.87E-4 ID:SGTC_1625|Compound:st003711|FD-Score:6.60|P-value:2.02E-10 ID:SGTC_1745|Compound:st081495|FD-Score:3.21|P-value:9.90E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-4.07|P-value:1.14E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.28|P-value:2.49E-7 ID:SGTC_1798|Compound:st045719|FD-Score:-4.42|P-value:2.97E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.05|P-value:5.20E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.68|P-value:2.02E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.31|P-value:7.13E-4 ID:SGTC_2072|Compound:5231554|FD-Score:5.63|P-value:4.28E-8 ID:SGTC_2074|Compound:5212007|FD-Score:4.97|P-value:1.10E-6 ID:SGTC_2245|Compound:6637752|FD-Score:-3.76|P-value:3.37E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.77|P-value:1.47E-4 ID:SGTC_2402|Compound:5553605|FD-Score:5.64|P-value:4.12E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.59|P-value:2.75E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.52|P-value:3.49E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.29|P-value:5.02E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.54|P-value:6.93E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.92|P-value:1.98E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.60|P-value:2.67E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.28|P-value:7.94E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.49|P-value:8.96E-6 ID:SGTC_3127|Compound:9126946|FD-Score:4.27|P-value:2.23E-5 ID:SGTC_3154|Compound:9100113|FD-Score:5.62|P-value:4.54E-8 ID:SGTC_3158|Compound:9100007|FD-Score:-4.13|P-value:9.11E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.33|P-value:6.64E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.59|P-value:2.78E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.99|P-value:6.47E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:5.09E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.77|P-value:2.61E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.68|P-value:2.06E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.71|P-value:1.83E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.62|P-value:2.51E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.70|P-value:1.87E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:5.16|P-value:4.38E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.55|P-value:6.75E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.69|P-value:1.93E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.54|P-value:7.19E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:6.55|P-value:2.64E-10 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.36|P-value:6.02E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.62|P-value:5.45E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.24|P-value:8.90E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.58|P-value:2.87E-4 ID:SGTC_1625|Compound:st003711|FD-Score:6.60|P-value:2.02E-10 ID:SGTC_1745|Compound:st081495|FD-Score:3.21|P-value:9.90E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-4.07|P-value:1.14E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.28|P-value:2.49E-7 ID:SGTC_1798|Compound:st045719|FD-Score:-4.42|P-value:2.97E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.05|P-value:5.20E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.68|P-value:2.02E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.31|P-value:7.13E-4 ID:SGTC_2072|Compound:5231554|FD-Score:5.63|P-value:4.28E-8 ID:SGTC_2074|Compound:5212007|FD-Score:4.97|P-value:1.10E-6 ID:SGTC_2245|Compound:6637752|FD-Score:-3.76|P-value:3.37E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.77|P-value:1.47E-4 ID:SGTC_2402|Compound:5553605|FD-Score:5.64|P-value:4.12E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.59|P-value:2.75E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.52|P-value:3.49E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.29|P-value:5.02E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.54|P-value:6.93E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.92|P-value:1.98E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.60|P-value:2.67E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.28|P-value:7.94E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.49|P-value:8.96E-6 ID:SGTC_3127|Compound:9126946|FD-Score:4.27|P-value:2.23E-5 ID:SGTC_3154|Compound:9100113|FD-Score:5.62|P-value:4.54E-8 ID:SGTC_3158|Compound:9100007|FD-Score:-4.13|P-value:9.11E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.33|P-value:6.64E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.59|P-value:2.78E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.99|P-value:6.47E-5

Top fitness defect scores for YER110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1625 st003711 6.60 30.1 µM 2.02E-10 calcium & mitochondrial duress 5 2.12E-11
2 SGTC_1074 carmofur 6.55 3.8 µM 2.64E-10 exosome 2 2.87E-11
3 SGTC_2402 5553605 5.64 200.0 µM 4.12E-8 6 8.51E-9
4 SGTC_2072 5231554 5.63 129.0 µM 4.28E-8 2 8.89E-9
5 SGTC_3154 9100113 5.62 49.5 µM 4.54E-8 9 9.49E-9
6 SGTC_1792 st045773 5.28 43.6 µM 2.49E-7 9 6.43E-8
7 SGTC_760 0568-0725 5.16 82.9 µM 4.38E-7 1 1.21E-7
8 SGTC_2074 5212007 4.97 75.4 µM 1.10E-6 5 3.41E-7
9 SGTC_404 fumagillin 4.77 50.0 µM 2.61E-6 6 8.99E-7
10 SGTC_1017 4239-0030 4.54 168.0 µM 7.19E-6 15 2.80E-6
11 SGTC_3050 9093513 4.49 49.5 µM 8.96E-6 12 3.58E-6
12 SGTC_3127 9126946 4.27 49.5 µM 2.23E-5 ERG2 15 9.94E-6
13 SGTC_1875 nocodazole 4.05 6.0 µM 5.20E-5 tubulin folding & SWR complex 50 2.55E-5
14 SGTC_3303 9125618 3.99 40.6 µM 6.47E-5 42 3.25E-5
15 SGTC_1958 st076513 3.86 41.9 µM 1.08E-4 60S ribosome export 31 5.76E-5
16 SGTC_2247 cerulenin 3.77 830.0 nM 1.47E-4 21 8.10E-5
17 SGTC_456 gingerol 3.71 170.0 µM 1.83E-4 29 1.04E-4
18 SGTC_716 1683-5115 3.70 658.0 µM 1.87E-4 31 1.06E-4
19 SGTC_946 3434-1334 3.69 87.4 µM 1.93E-4 37 1.10E-4
20 SGTC_1962 st076595 3.68 64.5 µM 2.02E-4 redox potentiating 34 1.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.95E-10 YCR031C RPS14A hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication
0.099 8.81E-9 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.099 9.61E-9 YBR250W SPO23 hom Protein of unknown function; associates with meiosis-specific protein Spo1p
0.098 1.55E-8 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.094 4.70E-8 YHR049W FSH1 hom Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
0.094 4.93E-8 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.087 4.66E-7 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.087 5.25E-7 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.086 6.65E-7 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.081 2.97E-6 YMR224C MRE11 hom Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
0.080 3.12E-6 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.080 4.04E-6 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.079 4.57E-6 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.076 9.69E-6 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.075 1.55E-5 YER039C HVG1 hom Protein of unknown function, has homology to Vrg4p