YER111C / SWI4

DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER111C / SWI4

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:5.52|P-value:5.62E-8 ID:SGTC_29|Compound:0299-0004|FD-Score:9.19|P-value:6.82E-19 ID:SGTC_58|Compound:0957-0393|FD-Score:4.84|P-value:1.56E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:5.90|P-value:7.06E-9 ID:SGTC_117|Compound:lucigenin|FD-Score:5.46|P-value:7.46E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:3.72|P-value:1.62E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.90|P-value:8.50E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.85|P-value:1.02E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.58|P-value:2.74E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.93|P-value:7.51E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.94|P-value:7.30E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.11|P-value:4.43E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:7.04|P-value:7.26E-12 ID:SGTC_446|Compound:go6976|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.37|P-value:1.19E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:4.02E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:5.10|P-value:4.66E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.75|P-value:2.05E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-5.14|P-value:5.96E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:3.57|P-value:2.80E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.09|P-value:3.99E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.77|P-value:1.90E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.34|P-value:8.48E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:5.78|P-value:1.43E-8 ID:SGTC_911|Compound:3456-4043|FD-Score:3.28|P-value:7.49E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:5.32|P-value:1.60E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.66|P-value:3.63E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.68|P-value:1.88E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.06|P-value:5.65E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.29|P-value:7.42E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.51|P-value:3.49E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.44|P-value:9.59E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.32|P-value:1.57E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.39|P-value:1.15E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.73|P-value:2.69E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.34|P-value:6.32E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.49|P-value:5.11E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.10|P-value:4.61E-7 ID:SGTC_1786|Compound:berberine|FD-Score:3.20|P-value:9.75E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.71|P-value:2.41E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.76|P-value:1.42E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.67|P-value:1.95E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.31|P-value:2.43E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.35|P-value:6.04E-4 ID:SGTC_1830|Compound:st055982|FD-Score:-3.78|P-value:1.86E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-4.66|P-value:5.39E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.94|P-value:7.26E-5 ID:SGTC_2110|Compound:5483698|FD-Score:5.57|P-value:4.21E-8 ID:SGTC_2114|Compound:5491910|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.57|P-value:2.83E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.92|P-value:7.96E-5 ID:SGTC_2223|Compound:6903751|FD-Score:3.64|P-value:2.21E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.38|P-value:5.53E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.48|P-value:1.10E-7 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.30|P-value:7.07E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.27|P-value:7.89E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.33|P-value:2.19E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.76|P-value:2.00E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.24|P-value:2.22E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.00|P-value:8.32E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.44|P-value:9.48E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.36|P-value:1.28E-7 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.51|P-value:3.44E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.68|P-value:2.62E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.33|P-value:1.53E-5 ID:SGTC_2683|Compound:piperine|FD-Score:3.43|P-value:4.57E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.48|P-value:3.94E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.89|P-value:8.85E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:4.33E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-3.49|P-value:5.15E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.95|P-value:9.77E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.82|P-value:1.59E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.72|P-value:2.74E-6 ID:SGTC_3078|Compound:9116413|FD-Score:3.24|P-value:8.62E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.68|P-value:1.90E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.36|P-value:1.35E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-4.44|P-value:1.40E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.77|P-value:1.90E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.33|P-value:1.51E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:5.52|P-value:5.62E-8 ID:SGTC_29|Compound:0299-0004|FD-Score:9.19|P-value:6.82E-19 ID:SGTC_58|Compound:0957-0393|FD-Score:4.84|P-value:1.56E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:5.90|P-value:7.06E-9 ID:SGTC_117|Compound:lucigenin|FD-Score:5.46|P-value:7.46E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:3.72|P-value:1.62E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.90|P-value:8.50E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.85|P-value:1.02E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.58|P-value:2.74E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.93|P-value:7.51E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.94|P-value:7.30E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.11|P-value:4.43E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:7.04|P-value:7.26E-12 ID:SGTC_446|Compound:go6976|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.37|P-value:1.19E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:4.02E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:5.10|P-value:4.66E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.75|P-value:2.05E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-5.14|P-value:5.96E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:3.57|P-value:2.80E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.09|P-value:3.99E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.77|P-value:1.90E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.34|P-value:8.48E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:5.78|P-value:1.43E-8 ID:SGTC_911|Compound:3456-4043|FD-Score:3.28|P-value:7.49E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:5.32|P-value:1.60E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.66|P-value:3.63E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.68|P-value:1.88E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.06|P-value:5.65E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.29|P-value:7.42E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.51|P-value:3.49E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.44|P-value:9.59E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.32|P-value:1.57E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.39|P-value:1.15E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.73|P-value:2.69E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.34|P-value:6.32E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.49|P-value:5.11E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.10|P-value:4.61E-7 ID:SGTC_1786|Compound:berberine|FD-Score:3.20|P-value:9.75E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.71|P-value:2.41E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.76|P-value:1.42E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.67|P-value:1.95E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.31|P-value:2.43E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.35|P-value:6.04E-4 ID:SGTC_1830|Compound:st055982|FD-Score:-3.78|P-value:1.86E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-4.66|P-value:5.39E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.94|P-value:7.26E-5 ID:SGTC_2110|Compound:5483698|FD-Score:5.57|P-value:4.21E-8 ID:SGTC_2114|Compound:5491910|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.57|P-value:2.83E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.92|P-value:7.96E-5 ID:SGTC_2223|Compound:6903751|FD-Score:3.64|P-value:2.21E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.38|P-value:5.53E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.48|P-value:1.10E-7 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.30|P-value:7.07E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.27|P-value:7.89E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.33|P-value:2.19E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.76|P-value:2.00E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.24|P-value:2.22E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.00|P-value:8.32E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.44|P-value:9.48E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.36|P-value:1.28E-7 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.51|P-value:3.44E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.68|P-value:2.62E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.33|P-value:1.53E-5 ID:SGTC_2683|Compound:piperine|FD-Score:3.43|P-value:4.57E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.48|P-value:3.94E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.89|P-value:8.85E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:4.33E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-3.49|P-value:5.15E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.95|P-value:9.77E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.82|P-value:1.59E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.72|P-value:2.74E-6 ID:SGTC_3078|Compound:9116413|FD-Score:3.24|P-value:8.62E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.68|P-value:1.90E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.36|P-value:1.35E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-4.44|P-value:1.40E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.77|P-value:1.90E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.33|P-value:1.51E-5

Top fitness defect scores for YER111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_29 0299-0004 9.19 13.0 µM 6.82E-19 4 2.05E-20
2 SGTC_403 arphamenine a 7.04 50.0 µM 7.26E-12 60S ribosome export 1 9.81E-13
3 SGTC_116 0155-0182 5.90 31.8 µM 7.06E-9 mitochondrial response to ROS 24 1.78E-9
4 SGTC_834 0312-0008 5.78 75.7 µM 1.43E-8 NEO1 19 3.84E-9
5 SGTC_2110 5483698 5.57 200.0 µM 4.21E-8 TSC3-RPN4 9 1.24E-8
6 SGTC_9 0092-0002 5.52 10.4 µM 5.62E-8 8 1.70E-8
7 SGTC_117 lucigenin 5.46 22.1 µM 7.46E-8 redox potentiating 46 2.32E-8
8 SGTC_453 enantio-paf c16 5.37 10.0 µM 1.19E-7 73 3.84E-8
9 SGTC_2582 agaric acid 5.36 100.0 µM 1.28E-7 redox potentiating 202 4.16E-8
10 SGTC_927 2425-1185 5.32 123.0 µM 1.60E-7 5 5.30E-8
11 SGTC_391 gliotoxin 5.11 8.3 µM 4.43E-7 36 1.61E-7
12 SGTC_1785 bathophenanthroline 5.10 24.0 µM 4.61E-7 heme requiring 19 1.68E-7
13 SGTC_518 1021-0119 5.10 62.6 µM 4.66E-7 ERG2 15 1.70E-7
14 SGTC_1207 2099-0101 5.06 141.0 µM 5.65E-7 4 2.10E-7
15 SGTC_58 0957-0393 4.84 9.0 µM 1.56E-6 cell wall 300 6.33E-7
16 SGTC_1468 k284-1086 4.73 134.0 µM 2.69E-6 DNA intercalators 14 1.14E-6
17 SGTC_3047 9092122 4.72 49.5 µM 2.74E-6 7 1.17E-6
18 SGTC_1132 3456-3614 4.66 2.5 µM 3.63E-6 tubulin folding & SWR complex 21 1.58E-6
19 SGTC_2578 7,8-dihydroxyflavone 4.44 64.4 µM 9.48E-6 25 4.50E-6
20 SGTC_1278 0874-0585 4.44 172.0 µM 9.59E-6 9 4.55E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 6.88E-27 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 1.02E-18 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.151 1.56E-18 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.134 6.25E-15 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.124 4.74E-13 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.123 7.17E-13 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.123 8.27E-13 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.116 1.67E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.114 3.99E-11 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.110 1.63E-10 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.110 1.80E-10 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.108 3.58E-10 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.106 7.03E-10 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.103 2.13E-9 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.100 6.85E-9 YKR048C NAP1 hom Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress