YER112W / LSM4

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER112W / LSM4

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:4.15|P-value:1.11E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:5.18|P-value:1.98E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:8.08|P-value:3.28E-13 ID:SGTC_108|Compound:0509-0257|FD-Score:6.32|P-value:9.48E-9 ID:SGTC_115|Compound:0527-0192|FD-Score:5.23|P-value:1.63E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.90|P-value:2.58E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.70|P-value:1.42E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.01|P-value:1.74E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:6.50|P-value:3.71E-9 ID:SGTC_263|Compound:alizarin|FD-Score:4.98|P-value:4.69E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.75|P-value:4.24E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.62|P-value:1.96E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.55|P-value:7.82E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-5.23|P-value:1.57E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.55|P-value:2.47E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.03|P-value:1.63E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:7.34|P-value:3.23E-11 ID:SGTC_765|Compound:1319-0117|FD-Score:6.64|P-value:1.69E-9 ID:SGTC_766|Compound:1391-0721|FD-Score:3.50|P-value:9.25E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-3.68|P-value:5.22E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.99|P-value:1.90E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.49|P-value:9.47E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.05|P-value:1.58E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.57|P-value:7.55E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.19|P-value:9.60E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.77|P-value:3.91E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.87|P-value:2.89E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.03|P-value:1.68E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.01|P-value:4.06E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.88|P-value:7.07E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:6.91|P-value:3.98E-10 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.76|P-value:4.00E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.59|P-value:7.08E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.06|P-value:1.54E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.35|P-value:9.62E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.09|P-value:1.35E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.53|P-value:8.32E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.83|P-value:3.20E-4 ID:SGTC_1818|Compound:st052136|FD-Score:7.43|P-value:1.83E-11 ID:SGTC_1827|Compound:berberine|FD-Score:4.74|P-value:1.23E-5 ID:SGTC_1829|Compound:berberine|FD-Score:6.91|P-value:3.77E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.10|P-value:1.63E-19 ID:SGTC_1845|Compound:st056753|FD-Score:-3.68|P-value:5.21E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.15|P-value:1.10E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.24|P-value:8.20E-5 ID:SGTC_2100|Compound:5377183|FD-Score:5.58|P-value:3.44E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.21|P-value:9.01E-5 ID:SGTC_2216|Compound:7189485|FD-Score:-3.51|P-value:8.72E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.62|P-value:6.43E-4 ID:SGTC_2226|Compound:7298446|FD-Score:5.34|P-value:9.98E-7 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:4.60|P-value:2.11E-5 ID:SGTC_2231|Compound:micatex|FD-Score:3.76|P-value:4.12E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.91|P-value:2.52E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.26|P-value:1.25E-8 ID:SGTC_2471|Compound:5466956|FD-Score:3.67|P-value:5.47E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.77|P-value:1.44E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.40|P-value:8.50E-21 ID:SGTC_2576|Compound:guaiol|FD-Score:3.79|P-value:3.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.65|P-value:1.77E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.91|P-value:2.52E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.48|P-value:9.67E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.51|P-value:9.09E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.38|P-value:4.90E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-5.06|P-value:3.26E-6 ID:SGTC_2867|Compound:9039098|FD-Score:6.96|P-value:2.85E-10 ID:SGTC_2905|Compound:7799065|FD-Score:5.16|P-value:2.19E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-3.86|P-value:2.91E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.59|P-value:3.13E-7 ID:SGTC_3024|Compound:9090631|FD-Score:3.74|P-value:4.39E-4 ID:SGTC_3032|Compound:9089427|FD-Score:5.53|P-value:4.23E-7 ID:SGTC_3039|Compound:9090270|FD-Score:5.92|P-value:6.79E-8 ID:SGTC_3142|Compound:9086498|FD-Score:4.33|P-value:5.89E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.97|P-value:2.03E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.45|P-value:3.71E-5 ID:SGTC_3217|Compound:9129673|FD-Score:6.06|P-value:3.44E-8 ID:SGTC_3219|Compound:9131112|FD-Score:5.92|P-value:7.02E-8 ID:SGTC_3272|Compound:9137413|FD-Score:3.60|P-value:6.84E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.82|P-value:9.09E-6 ID:SGTC_3316|Compound:9136639|FD-Score:5.15|P-value:2.33E-6 ID:SGTC_3319|Compound:9138450|FD-Score:4.19|P-value:9.67E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.49|P-value:9.59E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.15|P-value:1.11E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:5.18|P-value:1.98E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:8.08|P-value:3.28E-13 ID:SGTC_108|Compound:0509-0257|FD-Score:6.32|P-value:9.48E-9 ID:SGTC_115|Compound:0527-0192|FD-Score:5.23|P-value:1.63E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.90|P-value:2.58E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.70|P-value:1.42E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.01|P-value:1.74E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:6.50|P-value:3.71E-9 ID:SGTC_263|Compound:alizarin|FD-Score:4.98|P-value:4.69E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.75|P-value:4.24E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.62|P-value:1.96E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.55|P-value:7.82E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-5.23|P-value:1.57E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.55|P-value:2.47E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.03|P-value:1.63E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:7.34|P-value:3.23E-11 ID:SGTC_765|Compound:1319-0117|FD-Score:6.64|P-value:1.69E-9 ID:SGTC_766|Compound:1391-0721|FD-Score:3.50|P-value:9.25E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-3.68|P-value:5.22E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.99|P-value:1.90E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.49|P-value:9.47E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.05|P-value:1.58E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.57|P-value:7.55E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.19|P-value:9.60E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.77|P-value:3.91E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.87|P-value:2.89E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.03|P-value:1.68E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.01|P-value:4.06E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.88|P-value:7.07E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:6.91|P-value:3.98E-10 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.76|P-value:4.00E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.59|P-value:7.08E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.06|P-value:1.54E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.35|P-value:9.62E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.09|P-value:1.35E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.53|P-value:8.32E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.83|P-value:3.20E-4 ID:SGTC_1818|Compound:st052136|FD-Score:7.43|P-value:1.83E-11 ID:SGTC_1827|Compound:berberine|FD-Score:4.74|P-value:1.23E-5 ID:SGTC_1829|Compound:berberine|FD-Score:6.91|P-value:3.77E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.10|P-value:1.63E-19 ID:SGTC_1845|Compound:st056753|FD-Score:-3.68|P-value:5.21E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.15|P-value:1.10E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.24|P-value:8.20E-5 ID:SGTC_2100|Compound:5377183|FD-Score:5.58|P-value:3.44E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.21|P-value:9.01E-5 ID:SGTC_2216|Compound:7189485|FD-Score:-3.51|P-value:8.72E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.62|P-value:6.43E-4 ID:SGTC_2226|Compound:7298446|FD-Score:5.34|P-value:9.98E-7 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:4.60|P-value:2.11E-5 ID:SGTC_2231|Compound:micatex|FD-Score:3.76|P-value:4.12E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.91|P-value:2.52E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.26|P-value:1.25E-8 ID:SGTC_2471|Compound:5466956|FD-Score:3.67|P-value:5.47E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.77|P-value:1.44E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.40|P-value:8.50E-21 ID:SGTC_2576|Compound:guaiol|FD-Score:3.79|P-value:3.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.65|P-value:1.77E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.91|P-value:2.52E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.48|P-value:9.67E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.51|P-value:9.09E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.38|P-value:4.90E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-5.06|P-value:3.26E-6 ID:SGTC_2867|Compound:9039098|FD-Score:6.96|P-value:2.85E-10 ID:SGTC_2905|Compound:7799065|FD-Score:5.16|P-value:2.19E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-3.86|P-value:2.91E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.59|P-value:3.13E-7 ID:SGTC_3024|Compound:9090631|FD-Score:3.74|P-value:4.39E-4 ID:SGTC_3032|Compound:9089427|FD-Score:5.53|P-value:4.23E-7 ID:SGTC_3039|Compound:9090270|FD-Score:5.92|P-value:6.79E-8 ID:SGTC_3142|Compound:9086498|FD-Score:4.33|P-value:5.89E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.97|P-value:2.03E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.45|P-value:3.71E-5 ID:SGTC_3217|Compound:9129673|FD-Score:6.06|P-value:3.44E-8 ID:SGTC_3219|Compound:9131112|FD-Score:5.92|P-value:7.02E-8 ID:SGTC_3272|Compound:9137413|FD-Score:3.60|P-value:6.84E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.82|P-value:9.09E-6 ID:SGTC_3316|Compound:9136639|FD-Score:5.15|P-value:2.33E-6 ID:SGTC_3319|Compound:9138450|FD-Score:4.19|P-value:9.67E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.49|P-value:9.59E-4

Top fitness defect scores for YER112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2567 aureobasidin a 10.40 60.0 nM 8.50E-21 12 9.59E-26 0.08
2 SGTC_1844 rapamycin 10.10 4.0 nM 1.63E-19 10 3.95E-24 0.42
3 SGTC_97 0535-0701 8.08 19.1 µM 3.28E-13 60S ribosome export 4 3.35E-16 2.00
4 SGTC_1818 st052136 7.43 56.3 µM 1.83E-11 NEO1-PIK1 3 5.23E-14 0.55
5 SGTC_584 0986-0246 7.34 15.4 µM 3.23E-11 heme requiring 4 1.07E-13 0.28
6 SGTC_2867 9039098 6.96 71.4 µM 2.85E-10 iron homeostasis 2 1.65E-12 0.88
7 SGTC_1829 berberine 6.91 14.4 µM 3.77E-10 60S ribosome export 6 2.34E-12 2.06
8 SGTC_1592 4',5'-dihydroxyflavone 6.91 8.8 µM 3.98E-10 60S ribosome export 3 2.51E-12 2.36
9 SGTC_765 1319-0117 6.64 244.0 µM 1.69E-9 60S ribosome export 3 1.55E-11 1.39
10 SGTC_184 1494-0393 6.50 24.7 µM 3.71E-9 8 4.14E-11 0.52
11 SGTC_108 0509-0257 6.32 621.1 µM 9.48E-9 5 1.34E-10 0.31
12 SGTC_2257 7960413 6.26 200.0 µM 1.25E-8 NEO1-PIK1 8 1.91E-10 0.00
13 SGTC_3217 9129673 6.06 49.5 µM 3.44E-8 2 6.76E-10 0.76
14 SGTC_3039 9090270 5.92 49.5 µM 6.79E-8 RPP1 & pyrimidine depletion 2 1.58E-9 1.39
15 SGTC_3219 9131112 5.92 49.5 µM 7.02E-8 Golgi 5 1.65E-9 0.28
16 SGTC_2563 tomatine 5.77 8.5 µM 1.44E-7 5 4.08E-9 0.10
17 SGTC_2100 5377183 5.58 190.0 µM 3.44E-7 60S ribosome export 4 1.21E-8 0.61
18 SGTC_3032 9089427 5.53 49.5 µM 4.23E-7 60S ribosome export 2 1.57E-8 1.45
19 SGTC_1786 berberine 5.35 21.6 µM 9.62E-7 60S ribosome export 9 4.39E-8 0.17
20 SGTC_2226 7298446 5.34 200.0 µM 9.98E-7 1 4.60E-8 0.87

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 1.08E-76 YLR438C-A LSM3 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.212 2.36E-35 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.188 3.70E-28 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.165 7.60E-22 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.151 1.83E-18 YPL202C AFT2 hom Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication
0.150 2.84E-18 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.147 1.14E-17 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.137 1.41E-15 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.134 5.47E-15 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.131 2.39E-14 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.131 2.51E-14 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.129 6.25E-14 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.126 2.68E-13 YPL084W BRO1 hom Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
0.125 3.47E-13 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.122 1.07E-12 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors