YER113C / TMN3

Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YER113C / TMN3

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.79|P-value:3.39E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.11|P-value:5.39E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.24|P-value:2.95E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.40|P-value:1.71E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.23|P-value:3.34E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.93|P-value:9.39E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.10|P-value:5.50E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.84|P-value:2.65E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:6.11|P-value:6.00E-11 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.08|P-value:6.00E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.73|P-value:3.83E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.07|P-value:6.13E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.05|P-value:6.73E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.82|P-value:2.87E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.60|P-value:7.67E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.33|P-value:2.11E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.10|P-value:5.58E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.74|P-value:4.18E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.59|P-value:7.83E-5 ID:SGTC_1826|Compound:st055655|FD-Score:4.40|P-value:1.77E-6 ID:SGTC_1905|Compound:st060207|FD-Score:3.21|P-value:3.66E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.17|P-value:4.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:6.66|P-value:1.09E-12 ID:SGTC_2067|Compound:5224629|FD-Score:3.97|P-value:1.49E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.08|P-value:5.94E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.26|P-value:3.01E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.46|P-value:1.36E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.40|P-value:1.81E-6 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.79|P-value:2.22E-7 ID:SGTC_2673|Compound:kobusone|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.61|P-value:7.13E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.58|P-value:8.34E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-3.35|P-value:1.92E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-2.92|P-value:9.62E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.21|P-value:4.10E-6 ID:SGTC_3331|Compound:9141060|FD-Score:3.73|P-value:4.24E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:3.79|P-value:3.39E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.11|P-value:5.39E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.24|P-value:2.95E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.40|P-value:1.71E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.23|P-value:3.34E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.93|P-value:9.39E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.10|P-value:5.50E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.84|P-value:2.65E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:6.11|P-value:6.00E-11 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.08|P-value:6.00E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.73|P-value:3.83E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.07|P-value:6.13E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.05|P-value:6.73E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.82|P-value:2.87E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.60|P-value:7.67E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.33|P-value:2.11E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.10|P-value:5.58E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.74|P-value:4.18E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.59|P-value:7.83E-5 ID:SGTC_1826|Compound:st055655|FD-Score:4.40|P-value:1.77E-6 ID:SGTC_1905|Compound:st060207|FD-Score:3.21|P-value:3.66E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.17|P-value:4.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:6.66|P-value:1.09E-12 ID:SGTC_2067|Compound:5224629|FD-Score:3.97|P-value:1.49E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.08|P-value:5.94E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.26|P-value:3.01E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.46|P-value:1.36E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.40|P-value:1.81E-6 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.79|P-value:2.22E-7 ID:SGTC_2673|Compound:kobusone|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.61|P-value:7.13E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.58|P-value:8.34E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-3.35|P-value:1.92E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-2.92|P-value:9.62E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.21|P-value:4.10E-6 ID:SGTC_3331|Compound:9141060|FD-Score:3.73|P-value:4.24E-5

Top fitness defect scores for YER113C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2066 5222451 6.66 176.0 µM 1.09E-12 heme biosynthesis & mitochondrial translocase 4 1.35E-11
2 SGTC_182 3448-4371 6.11 550.5 µM 6.00E-11 8 4.98E-10
3 SGTC_2663 amphotericin b 4.79 100.0 µM 2.22E-7 5 8.18E-7
4 SGTC_1826 st055655 4.40 41.6 µM 1.77E-6 ERG2 31 5.33E-6
5 SGTC_2421 5690543 4.40 90.7 µM 1.81E-6 14 5.43E-6
6 SGTC_2067 5224629 3.97 34.1 µM 1.49E-5 27 3.64E-5
7 SGTC_137 0438-0332 3.84 85.4 µM 2.65E-5 ubiquinone biosynthesis & proteasome 131 6.15E-5
8 SGTC_1130 3454-2858 3.82 15.9 µM 2.87E-5 NEO1 95 6.60E-5
9 SGTC_24 0417-1663 3.79 219.0 µM 3.39E-5 20 7.68E-5
10 SGTC_1786 berberine 3.74 21.6 µM 4.18E-5 60S ribosome export 38 9.27E-5
11 SGTC_3331 9141060 3.73 2.0 µM 4.24E-5 cell wall 39 9.40E-5
12 SGTC_2705 st078069 3.61 42.8 µM 7.13E-5 11 1.50E-4
13 SGTC_1373 2887-0003 3.60 58.5 µM 7.67E-5 Golgi 29 1.61E-4
14 SGTC_1787 fluconazole 3.59 80.0 µM 7.83E-5 iron homeostasis 38 1.64E-4
15 SGTC_2749 bexarotene 3.58 57.4 µM 8.34E-5 36 1.73E-4
16 SGTC_425 3825-7017 3.46 13.1 µM 1.35E-4 40 2.68E-4
17 SGTC_2387 9077560 3.46 195.1 µM 1.36E-4 30 2.69E-4
18 SGTC_2684 capsaicin 3.43 100.0 µM 1.52E-4 31 2.98E-4
19 SGTC_77 0828-0286 3.40 12.5 µM 1.71E-4 TSC3-RPN4 61 3.32E-4
20 SGTC_2997 9067075 3.35 71.4 µM 2.08E-4 unfolded protein response 78 3.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.16E-7 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.090 1.87E-7 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.090 1.94E-7 YMR018W_p YMR018W_p hom Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
0.088 3.32E-7 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.088 3.40E-7 YKL123W_d YKL123W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
0.088 3.42E-7 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.087 4.74E-7 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.085 8.27E-7 YKR074W AIM29 hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
0.084 1.02E-6 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
0.081 2.29E-6 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.079 4.17E-6 YNL336W COS1 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.077 8.17E-6 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.075 1.46E-5 YPL213W LEA1 hom Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein
0.074 1.61E-5 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.074 1.62E-5 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions