YER114C / BOI2

Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER114C / BOI2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.55|P-value:5.02E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.54|P-value:5.16E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.02|P-value:1.42E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.36|P-value:9.44E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.07|P-value:6.87E-9 ID:SGTC_324|Compound:1315-0088|FD-Score:4.44|P-value:1.76E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.99|P-value:1.04E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.66|P-value:3.47E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.89|P-value:1.53E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.35|P-value:9.74E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.48|P-value:6.32E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.37|P-value:2.39E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.31|P-value:6.45E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.29|P-value:6.80E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.36|P-value:9.44E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.62|P-value:3.96E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.84|P-value:1.83E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.88|P-value:2.71E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.33|P-value:2.85E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.43|P-value:7.60E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.11|P-value:9.39E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.60|P-value:2.39E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-4.53|P-value:5.97E-6 ID:SGTC_1594|Compound:piperine|FD-Score:3.58|P-value:4.55E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.37|P-value:9.19E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.80|P-value:3.87E-6 ID:SGTC_1725|Compound:st036284|FD-Score:-4.48|P-value:7.63E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-3.27|P-value:7.45E-4 ID:SGTC_1749|Compound:st037932|FD-Score:7.23|P-value:6.12E-12 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.06|P-value:8.07E-5 ID:SGTC_1885|Compound:st057546|FD-Score:5.22|P-value:5.53E-7 ID:SGTC_2184|Compound:6075246|FD-Score:-4.50|P-value:6.76E-6 ID:SGTC_2313|Compound:7726885|FD-Score:4.29|P-value:3.31E-5 ID:SGTC_2381|Compound:9035592|FD-Score:5.34|P-value:3.07E-7 ID:SGTC_2482|Compound:5981709|FD-Score:4.77|P-value:4.42E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.41|P-value:2.18E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-3.63|P-value:2.12E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-5.45|P-value:7.82E-8 ID:SGTC_2705|Compound:st078069|FD-Score:-3.61|P-value:2.33E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.29|P-value:3.84E-7 ID:SGTC_2938|Compound:9059746|FD-Score:3.65|P-value:3.62E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.57|P-value:1.03E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.34|P-value:9.90E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.65|P-value:1.99E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_3117|Compound:9124945|FD-Score:4.02|P-value:9.40E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.40|P-value:4.81E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.63|P-value:3.84E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.38|P-value:8.87E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.55|P-value:5.02E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.54|P-value:5.16E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.02|P-value:1.42E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.36|P-value:9.44E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.07|P-value:6.87E-9 ID:SGTC_324|Compound:1315-0088|FD-Score:4.44|P-value:1.76E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.99|P-value:1.04E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.66|P-value:3.47E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.89|P-value:1.53E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.35|P-value:9.74E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.48|P-value:6.32E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.37|P-value:2.39E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.31|P-value:6.45E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.29|P-value:6.80E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.36|P-value:9.44E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.62|P-value:3.96E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.84|P-value:1.83E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.88|P-value:2.71E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.33|P-value:2.85E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.43|P-value:7.60E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.11|P-value:9.39E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.60|P-value:2.39E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-4.53|P-value:5.97E-6 ID:SGTC_1594|Compound:piperine|FD-Score:3.58|P-value:4.55E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.37|P-value:9.19E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.80|P-value:3.87E-6 ID:SGTC_1725|Compound:st036284|FD-Score:-4.48|P-value:7.63E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-3.27|P-value:7.45E-4 ID:SGTC_1749|Compound:st037932|FD-Score:7.23|P-value:6.12E-12 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.06|P-value:8.07E-5 ID:SGTC_1885|Compound:st057546|FD-Score:5.22|P-value:5.53E-7 ID:SGTC_2184|Compound:6075246|FD-Score:-4.50|P-value:6.76E-6 ID:SGTC_2313|Compound:7726885|FD-Score:4.29|P-value:3.31E-5 ID:SGTC_2381|Compound:9035592|FD-Score:5.34|P-value:3.07E-7 ID:SGTC_2482|Compound:5981709|FD-Score:4.77|P-value:4.42E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.41|P-value:2.18E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-3.63|P-value:2.12E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-5.45|P-value:7.82E-8 ID:SGTC_2705|Compound:st078069|FD-Score:-3.61|P-value:2.33E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.29|P-value:3.84E-7 ID:SGTC_2938|Compound:9059746|FD-Score:3.65|P-value:3.62E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.57|P-value:1.03E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.34|P-value:9.90E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.65|P-value:1.99E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_3117|Compound:9124945|FD-Score:4.02|P-value:9.40E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.40|P-value:4.81E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.63|P-value:3.84E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.38|P-value:8.87E-4

Top fitness defect scores for YER114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1749 st037932 7.23 54.2 µM 6.12E-12 2 2.47E-13
2 SGTC_138 0850-0259 6.07 40.9 µM 6.87E-9 cell wall 103 6.51E-10
3 SGTC_2634 4'-methoxyflavone 5.41 100.0 µM 2.18E-7 9 3.17E-8
4 SGTC_2381 9035592 5.34 200.0 µM 3.07E-7 4 4.66E-8
5 SGTC_2831 7999036 5.29 19.5 µM 3.84E-7 14 5.98E-8
6 SGTC_1885 st057546 5.22 99.9 µM 5.53E-7 4 9.01E-8
7 SGTC_1581 himbacine 5.11 57.9 µM 9.39E-7 Golgi 30 1.63E-7
8 SGTC_116 0155-0182 5.02 31.8 µM 1.42E-6 mitochondrial response to ROS 41 2.60E-7
9 SGTC_1467 k284-1082 4.88 293.0 µM 2.71E-6 6 5.38E-7
10 SGTC_1679 4130-1276 4.80 6.7 µM 3.87E-6 Golgi 41 8.03E-7
11 SGTC_2482 5981709 4.77 142.7 µM 4.42E-6 PDR1 24 9.34E-7
12 SGTC_2981 9013952 4.57 39.0 µM 1.03E-5 29 2.41E-6
13 SGTC_324 1315-0088 4.44 19.6 µM 1.76E-5 RSC & ERG11 6 4.43E-6
14 SGTC_817 1391-0715 4.37 46.0 µM 2.39E-5 12 6.24E-6
15 SGTC_1509 1326-1131 4.33 80.0 µM 2.85E-5 7 7.58E-6
16 SGTC_2313 7726885 4.29 200.0 µM 3.31E-5 RPP1 & pyrimidine depletion 26 8.99E-6
17 SGTC_1844 rapamycin 4.06 4.0 nM 8.07E-5 154 2.45E-5
18 SGTC_3117 9124945 4.02 49.5 µM 9.40E-5 4 2.91E-5
19 SGTC_530 4358-1714 3.99 28.0 µM 1.04E-4 45 3.27E-5
20 SGTC_552 k242-0005 3.89 476.0 µM 1.53E-4 16 5.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.70E-13 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.122 1.15E-12 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.115 2.89E-11 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.112 8.67E-11 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.109 2.52E-10 YBR233W PBP2 hom RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress
0.107 5.77E-10 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.102 2.67E-9 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.098 1.27E-8 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.098 1.51E-8 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.096 2.56E-8 YPR095C SYT1 hom Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
0.093 7.59E-8 YHR075C PPE1 hom Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
0.091 1.49E-7 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.090 1.79E-7 YOL094C RFC4 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.089 2.61E-7 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.088 2.98E-7 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN