YER115C / SPR6

Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YER115C / SPR6

Click on Significant Values for Screen Details ID:SGTC_210|Compound:3551-0445|FD-Score:-3.53|P-value:2.62E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.22|P-value:8.56E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.20|P-value:9.14E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.39|P-value:4.79E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.76|P-value:1.24E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.21|P-value:8.78E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.24|P-value:7.35E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.13|P-value:2.75E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.62|P-value:2.09E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.50|P-value:3.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.19|P-value:2.15E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.60|P-value:2.04E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.43|P-value:4.09E-4 ID:SGTC_1757|Compound:st041620|FD-Score:5.02|P-value:4.71E-7 ID:SGTC_1784|Compound:st039334|FD-Score:3.87|P-value:8.05E-5 ID:SGTC_1960|Compound:st011366|FD-Score:-3.74|P-value:1.21E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.22|P-value:1.89E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.79|P-value:1.10E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.03|P-value:4.13E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.27|P-value:1.56E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.26|P-value:7.48E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.10|P-value:2.83E-7 ID:SGTC_2780|Compound:5215298|FD-Score:8.55|P-value:3.30E-17 ID:SGTC_2784|Compound:7567673|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.62|P-value:2.90E-6 ID:SGTC_2834|Compound:9001755|FD-Score:3.45|P-value:3.81E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.39|P-value:4.70E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.50|P-value:3.20E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.52|P-value:3.48E-8 ID:SGTC_2965|Compound:9082772|FD-Score:5.91|P-value:3.89E-9 ID:SGTC_3111|Compound:9122088|FD-Score:3.18|P-value:9.59E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.26|P-value:7.39E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.38|P-value:4.92E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.56|P-value:2.56E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.93|P-value:5.60E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.25|P-value:1.64E-5 ID:SGTC_3348|Compound:9149464|FD-Score:3.48|P-value:3.46E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.53|P-value:2.62E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.22|P-value:8.56E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.20|P-value:9.14E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.39|P-value:4.79E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.76|P-value:1.24E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.21|P-value:8.78E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.24|P-value:7.35E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.13|P-value:2.75E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.62|P-value:2.09E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.50|P-value:3.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.19|P-value:2.15E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.60|P-value:2.04E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.43|P-value:4.09E-4 ID:SGTC_1757|Compound:st041620|FD-Score:5.02|P-value:4.71E-7 ID:SGTC_1784|Compound:st039334|FD-Score:3.87|P-value:8.05E-5 ID:SGTC_1960|Compound:st011366|FD-Score:-3.74|P-value:1.21E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.22|P-value:1.89E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.79|P-value:1.10E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.03|P-value:4.13E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.27|P-value:1.56E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.26|P-value:7.48E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.10|P-value:2.83E-7 ID:SGTC_2780|Compound:5215298|FD-Score:8.55|P-value:3.30E-17 ID:SGTC_2784|Compound:7567673|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.62|P-value:2.90E-6 ID:SGTC_2834|Compound:9001755|FD-Score:3.45|P-value:3.81E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.39|P-value:4.70E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.50|P-value:3.20E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.52|P-value:3.48E-8 ID:SGTC_2965|Compound:9082772|FD-Score:5.91|P-value:3.89E-9 ID:SGTC_3111|Compound:9122088|FD-Score:3.18|P-value:9.59E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.26|P-value:7.39E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.38|P-value:4.92E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.56|P-value:2.56E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.93|P-value:5.60E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.25|P-value:1.64E-5 ID:SGTC_3348|Compound:9149464|FD-Score:3.48|P-value:3.46E-4

Top fitness defect scores for YER115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2780 5215298 8.55 71.4 µM 3.30E-17 3 6.34E-18
2 SGTC_2965 9082772 5.91 38.6 µM 3.89E-9 mitochondrial response to ROS 10 1.71E-9
3 SGTC_2944 9067346 5.52 25.6 µM 3.48E-8 4 1.69E-8
4 SGTC_1221 2958-7315 5.13 257.0 µM 2.75E-7 4 1.46E-7
5 SGTC_1757 st041620 5.02 31.8 µM 4.71E-7 20 2.57E-7
6 SGTC_2463 5473429 4.27 200.0 µM 1.56E-5 ERG2 11 9.93E-6
7 SGTC_3331 9141060 4.25 2.0 µM 1.64E-5 cell wall 24 1.05E-5
8 SGTC_1971 st069429 4.22 63.5 µM 1.89E-5 60S ribosome export 9 1.21E-5
9 SGTC_1720 st037298 4.19 9.5 µM 2.15E-5 30 1.39E-5
10 SGTC_2336 9001819 4.03 198.7 µM 4.13E-5 heme biosynthesis & mitochondrial translocase 52 2.74E-5
11 SGTC_1784 st039334 3.87 36.3 µM 8.05E-5 21 5.51E-5
12 SGTC_2019 4016004 3.79 108.0 µM 1.10E-4 35 7.63E-5
13 SGTC_992 3909-8734 3.76 162.0 µM 1.24E-4 25 8.65E-5
14 SGTC_2784 7567673 3.63 72.7 µM 1.99E-4 iron homeostasis 39 1.42E-4
15 SGTC_1353 1498-1206 3.62 8.1 µM 2.09E-4 mitochondrial response to ROS 65 1.49E-4
16 SGTC_3209 9113616 3.56 49.5 µM 2.56E-4 41 1.85E-4
17 SGTC_1719 st032227 3.50 49.2 µM 3.19E-4 37 2.32E-4
18 SGTC_2863 9028737 3.50 58.4 µM 3.20E-4 13 2.33E-4
19 SGTC_3348 9149464 3.48 3.5 µM 3.46E-4 26 2.53E-4
20 SGTC_2834 9001755 3.45 58.4 µM 3.81E-4 50 2.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.27E-15 YPL109C_p YPL109C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.130 3.65E-14 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.118 7.01E-12 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.110 1.84E-10 YDL011C_d YDL011C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
0.105 1.25E-9 YCR073C SSK22 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
0.101 3.86E-9 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.098 1.09E-8 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.096 2.59E-8 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.095 3.93E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.092 1.01E-7 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.088 2.88E-7 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.087 3.95E-7 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.087 5.06E-7 YOR315W SFG1 hom Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
0.085 7.30E-7 YPL152W-A_p YPL152W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.085 8.68E-7 YKL165C MCD4 het Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes