YER117W / RPL23B

Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER117W / RPL23B

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:6.09|P-value:2.72E-10 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.05|P-value:9.29E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:-3.47|P-value:1.98E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.63|P-value:1.19E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:3.17|P-value:6.29E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.78|P-value:5.65E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:5.33|P-value:2.85E-8 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.79|P-value:5.51E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.11|P-value:7.63E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.95|P-value:2.90E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.31|P-value:3.68E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.12|P-value:7.50E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.53|P-value:1.63E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:5.84|P-value:1.36E-9 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:7.31|P-value:4.80E-14 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.66|P-value:9.48E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.23|P-value:4.95E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.80|P-value:5.32E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.50|P-value:1.81E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:5.38|P-value:2.13E-8 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.49|P-value:1.86E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.20|P-value:5.54E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.84|P-value:4.58E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.47|P-value:2.03E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.21|P-value:5.34E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.42|P-value:3.38E-6 ID:SGTC_2401|Compound:5128683|FD-Score:3.13|P-value:7.07E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.06|P-value:8.98E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.38|P-value:2.81E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.18|P-value:6.00E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.17|P-value:6.18E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.58|P-value:1.52E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.18|P-value:5.93E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.11|P-value:7.75E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.87|P-value:4.04E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.26|P-value:4.43E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.15|P-value:6.69E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.50|P-value:2.28E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-3.09|P-value:7.94E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.47|P-value:2.57E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.14|P-value:1.25E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-4.74|P-value:6.68E-7 ID:SGTC_3291|Compound:9121177|FD-Score:3.98|P-value:2.54E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:6.09|P-value:2.72E-10 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.05|P-value:9.29E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:-3.47|P-value:1.98E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.63|P-value:1.19E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:3.17|P-value:6.29E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.78|P-value:5.65E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:5.33|P-value:2.85E-8 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.79|P-value:5.51E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.11|P-value:7.63E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.95|P-value:2.90E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.31|P-value:3.68E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.12|P-value:7.50E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.53|P-value:1.63E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:5.84|P-value:1.36E-9 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:7.31|P-value:4.80E-14 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.66|P-value:9.48E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.23|P-value:4.95E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.80|P-value:5.32E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.50|P-value:1.81E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:5.38|P-value:2.13E-8 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.49|P-value:1.86E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.20|P-value:5.54E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.84|P-value:4.58E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.47|P-value:2.03E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.21|P-value:5.34E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.42|P-value:3.38E-6 ID:SGTC_2401|Compound:5128683|FD-Score:3.13|P-value:7.07E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.06|P-value:8.98E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.38|P-value:2.81E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.18|P-value:6.00E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.17|P-value:6.18E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.58|P-value:1.52E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.18|P-value:5.93E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.11|P-value:7.75E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.87|P-value:4.04E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.26|P-value:4.43E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.15|P-value:6.69E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.50|P-value:2.28E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-3.09|P-value:7.94E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.47|P-value:2.57E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.14|P-value:1.25E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-4.74|P-value:6.68E-7 ID:SGTC_3291|Compound:9121177|FD-Score:3.98|P-value:2.54E-5

Top fitness defect scores for YER117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1178 0988-0033 7.31 191.0 µM 4.80E-14 2 1.38E-13
2 SGTC_75 0159-0059 6.09 199.0 µM 2.72E-10 fatty acid desaturase (OLE1) 4 5.69E-10
3 SGTC_793 0488-0545 5.84 106.0 µM 1.36E-9 3 2.67E-9
4 SGTC_1424 4048-1941 5.38 275.0 µM 2.13E-8 8 3.80E-8
5 SGTC_154 3389-1638 5.33 511.1 µM 2.85E-8 5 5.03E-8
6 SGTC_150 3970-0969 4.78 77.2 µM 5.65E-7 39 8.92E-7
7 SGTC_140 0062-0056 4.63 502.5 µM 1.19E-6 10 1.82E-6
8 SGTC_2604 4'-hydroxychalcone 4.58 11.3 µM 1.52E-6 22 2.32E-6
9 SGTC_2967 9089538 4.50 49.9 µM 2.28E-6 20 3.42E-6
10 SGTC_3129 9127257 4.47 49.5 µM 2.57E-6 14 3.85E-6
11 SGTC_2364 9055074 4.42 200.0 µM 3.38E-6 14 5.01E-6
12 SGTC_2086 5274770 4.17 176.6 µM 1.07E-5 19 1.52E-5
13 SGTC_3224 9130643 4.14 49.5 µM 1.25E-5 RPP1 & pyrimidine depletion 26 1.77E-5
14 SGTC_3291 9121177 3.98 71.4 µM 2.54E-5 12 3.50E-5
15 SGTC_233 rapamycin 3.95 362.0 pM 2.90E-5 11 3.98E-5
16 SGTC_2854 9024559 3.87 71.4 µM 4.04E-5 25 5.47E-5
17 SGTC_2131 toluylene red 3.84 5.3 µM 4.58E-5 60S ribosome export 27 6.18E-5
18 SGTC_1196 1588-0294 3.66 184.0 µM 9.48E-5 20 1.25E-4
19 SGTC_74 000s-0487 3.57 160.3 µM 1.38E-4 30 1.79E-4
20 SGTC_633 0437-0093 3.53 97.7 µM 1.63E-4 DNA intercalators 21 2.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.80E-9 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.098 1.55E-8 YNL319W_d YNL319W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
0.095 4.22E-8 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.077 8.38E-6 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.073 2.47E-5 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.071 3.49E-5 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.070 4.82E-5 YKR060W UTP30 hom Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit
0.070 5.61E-5 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
0.068 7.63E-5 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.068 8.22E-5 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.066 1.21E-4 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.066 1.28E-4 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.065 1.55E-4 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.064 2.13E-4 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.064 2.27E-4 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex