YER119C / AVT6

Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER119C / AVT6

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-2.86|P-value:9.78E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:8.41E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:2.92|P-value:8.67E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.05|P-value:5.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.22|P-value:2.71E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.37|P-value:1.31E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.44|P-value:9.82E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.53|P-value:6.70E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.41|P-value:1.26E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.27|P-value:2.24E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.13|P-value:3.47E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.19|P-value:3.07E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:5.07E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:2.97|P-value:7.07E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.66|P-value:4.17E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.01|P-value:5.55E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-4.45|P-value:7.45E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.69|P-value:3.62E-5 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.46|P-value:1.02E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.64|P-value:3.09E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:3.05|P-value:5.32E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.12|P-value:3.63E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.89|P-value:9.63E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.21|P-value:2.56E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-4.81|P-value:9.86E-8 ID:SGTC_1630|Compound:st005209|FD-Score:2.96|P-value:7.34E-4 ID:SGTC_1766|Compound:st045414|FD-Score:2.95|P-value:7.58E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.36|P-value:1.52E-4 ID:SGTC_1950|Compound:st077106|FD-Score:6.74|P-value:2.07E-13 ID:SGTC_2031|Compound:5180455|FD-Score:3.73|P-value:3.05E-5 ID:SGTC_2064|Compound:5220758|FD-Score:2.96|P-value:7.40E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.01|P-value:6.27E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.30|P-value:1.93E-6 ID:SGTC_2171|Compound:5739187|FD-Score:-3.77|P-value:2.22E-5 ID:SGTC_2195|Compound:6536160|FD-Score:2.90|P-value:9.22E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.08|P-value:4.16E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.05|P-value:6.87E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.75|P-value:2.78E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.49|P-value:7.73E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-4.21|P-value:2.61E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.02|P-value:5.92E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.22|P-value:2.68E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.01|P-value:6.09E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.01|P-value:6.21E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:2.97|P-value:7.17E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.83|P-value:1.92E-5 ID:SGTC_2810|Compound:7959871|FD-Score:2.94|P-value:8.09E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.56|P-value:5.79E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.12|P-value:4.06E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.87|P-value:1.58E-5 ID:SGTC_3179|Compound:9107801|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.05|P-value:5.32E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.16|P-value:3.47E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.33|P-value:1.76E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-2.86|P-value:9.78E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:8.41E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:2.92|P-value:8.67E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.05|P-value:5.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.22|P-value:2.71E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.37|P-value:1.31E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.44|P-value:9.82E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.53|P-value:6.70E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.41|P-value:1.26E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.27|P-value:2.24E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.13|P-value:3.47E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.19|P-value:3.07E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:5.07E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:2.97|P-value:7.07E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.66|P-value:4.17E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.01|P-value:5.55E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-4.45|P-value:7.45E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.69|P-value:3.62E-5 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.46|P-value:1.02E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.64|P-value:3.09E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:3.05|P-value:5.32E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.12|P-value:3.63E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.89|P-value:9.63E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.21|P-value:2.56E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-4.81|P-value:9.86E-8 ID:SGTC_1630|Compound:st005209|FD-Score:2.96|P-value:7.34E-4 ID:SGTC_1766|Compound:st045414|FD-Score:2.95|P-value:7.58E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.36|P-value:1.52E-4 ID:SGTC_1950|Compound:st077106|FD-Score:6.74|P-value:2.07E-13 ID:SGTC_2031|Compound:5180455|FD-Score:3.73|P-value:3.05E-5 ID:SGTC_2064|Compound:5220758|FD-Score:2.96|P-value:7.40E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.01|P-value:6.27E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.30|P-value:1.93E-6 ID:SGTC_2171|Compound:5739187|FD-Score:-3.77|P-value:2.22E-5 ID:SGTC_2195|Compound:6536160|FD-Score:2.90|P-value:9.22E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.08|P-value:4.16E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.05|P-value:6.87E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.75|P-value:2.78E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.49|P-value:7.73E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-4.21|P-value:2.61E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.02|P-value:5.92E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.22|P-value:2.68E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.01|P-value:6.09E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.01|P-value:6.21E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:2.97|P-value:7.17E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.83|P-value:1.92E-5 ID:SGTC_2810|Compound:7959871|FD-Score:2.94|P-value:8.09E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.56|P-value:5.79E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.12|P-value:4.06E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.87|P-value:1.58E-5 ID:SGTC_3179|Compound:9107801|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.05|P-value:5.32E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.16|P-value:3.47E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.33|P-value:1.76E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.11|P-value:4.21E-4

Top fitness defect scores for YER119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1950 st077106 6.74 7.2 µM 2.07E-13 RNA processing & uracil transport 5 8.10E-12
2 SGTC_1511 0906-3109 4.64 28.5 µM 3.09E-7 excess fatty acid 25 1.77E-6
3 SGTC_2070 5230947 4.30 200.0 µM 1.93E-6 4 8.69E-6
4 SGTC_794 k038-0031 4.27 316.0 µM 2.24E-6 ubiquinone biosynthesis & proteasome 100 9.88E-6
5 SGTC_2315 7733312 4.05 200.0 µM 6.87E-6 22 2.61E-5
6 SGTC_270 tamoxifen 4.00 5.5 µM 8.41E-6 NEO1 23 3.12E-5
7 SGTC_3164 9100705 3.87 49.5 µM 1.58E-5 5 5.38E-5
8 SGTC_2803 7707263 3.83 71.4 µM 1.92E-5 30 6.39E-5
9 SGTC_2332 7982454 3.75 138.9 µM 2.78E-5 57 8.81E-5
10 SGTC_2031 5180455 3.73 200.0 µM 3.05E-5 15 9.53E-5
11 SGTC_1358 1509-0022 3.69 2.5 µM 3.62E-5 16 1.11E-4
12 SGTC_1078 idebenone 3.66 36.1 µM 4.17E-5 Golgi 53 1.25E-4
13 SGTC_1397 3532-0190 3.46 20.1 µM 1.02E-4 11 2.72E-4
14 SGTC_749 1000-0129 3.41 128.0 µM 1.26E-4 amide catabolism 38 3.28E-4
15 SGTC_1797 st048695 3.36 56.8 µM 1.52E-4 NEO1 93 3.86E-4
16 SGTC_3248 9135562 3.33 49.5 µM 1.76E-4 23 4.38E-4
17 SGTC_2470 5664817 3.22 21.7 µM 2.68E-4 30 6.33E-4
18 SGTC_453 enantio-paf c16 3.22 10.0 µM 2.71E-4 214 6.38E-4
19 SGTC_825 1988-2224 3.19 89.6 µM 3.07E-4 cell wall signaling 67 7.12E-4
20 SGTC_3244 9134489 3.16 49.5 µM 3.47E-4 46 7.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.47E-8 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
0.091 1.21E-7 YHR009C_p TDA3_p hom Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1
0.087 4.33E-7 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.087 4.59E-7 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.57E-7 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.080 3.47E-6 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.076 1.08E-5 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.074 1.59E-5 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.074 1.80E-5 YML085C TUB1 het Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
0.072 2.93E-5 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.070 4.88E-5 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.070 5.53E-5 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.069 6.05E-5 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.069 6.92E-5 YPL261C_d YPL261C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
0.069 6.97E-5 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane