YER119C-A_d

Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2

Zygosity: Homozygous strain
fixedexpanded
Profile for YER119C-A / YER119C-A

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:4.38|P-value:9.85E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:5.01|P-value:1.04E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:5.62|P-value:9.06E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:9.53|P-value:2.81E-16 ID:SGTC_157|Compound:1348-1695|FD-Score:4.04|P-value:3.00E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.28|P-value:3.70E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.00|P-value:8.85E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.94|P-value:4.14E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.81|P-value:3.71E-9 ID:SGTC_347|Compound:4534-1311|FD-Score:3.97|P-value:3.70E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:9.02|P-value:8.92E-15 ID:SGTC_439|Compound:amiodarone|FD-Score:5.42|P-value:2.09E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.29|P-value:3.54E-6 ID:SGTC_447|Compound:ml7|FD-Score:4.78|P-value:2.49E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.99|P-value:1.81E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:8.90|P-value:2.00E-14 ID:SGTC_550|Compound:4123-0385|FD-Score:4.04|P-value:3.01E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.76|P-value:2.54E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:5.55|P-value:1.20E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:4.63|P-value:4.16E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.64|P-value:9.69E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.51|P-value:6.41E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:5.52|P-value:1.35E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.89|P-value:2.37E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.03|P-value:3.00E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-4.28|P-value:1.35E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-4.34|P-value:1.13E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.07|P-value:2.77E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.75|P-value:7.15E-4 ID:SGTC_1640|Compound:st009078|FD-Score:4.40|P-value:9.37E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-5.81|P-value:3.91E-7 ID:SGTC_1674|Compound:st016616|FD-Score:-5.27|P-value:3.66E-6 ID:SGTC_1677|Compound:st019204|FD-Score:-4.02|P-value:3.07E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:7.54|P-value:7.57E-11 ID:SGTC_1683|Compound:st010134|FD-Score:7.73|P-value:2.53E-11 ID:SGTC_1687|Compound:st020778|FD-Score:5.01|P-value:1.05E-5 ID:SGTC_1712|Compound:st032288|FD-Score:13.10|P-value:5.10E-29 ID:SGTC_1760|Compound:st045453|FD-Score:10.30|P-value:1.03E-18 ID:SGTC_1800|Compound:st050079|FD-Score:5.23|P-value:4.44E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.36|P-value:2.69E-6 ID:SGTC_1803|Compound:st050068|FD-Score:7.13|P-value:6.95E-10 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.38|P-value:1.85E-10 ID:SGTC_2036|Compound:5160441|FD-Score:4.73|P-value:2.98E-5 ID:SGTC_2393|Compound:9031399|FD-Score:7.44|P-value:1.33E-10 ID:SGTC_2397|Compound:5161689|FD-Score:3.95|P-value:4.04E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.38|P-value:9.85E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.71|P-value:8.20E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-4.81|P-value:2.13E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.34|P-value:1.14E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.43|P-value:8.35E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.08|P-value:2.69E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.84|P-value:1.96E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.83|P-value:5.72E-4 ID:SGTC_2836|Compound:9010338|FD-Score:5.18|P-value:5.40E-6 ID:SGTC_2845|Compound:9003024|FD-Score:8.63|P-value:1.15E-13 ID:SGTC_2852|Compound:9023854|FD-Score:3.92|P-value:4.41E-4 ID:SGTC_2970|Compound:9090938|FD-Score:5.35|P-value:2.78E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.97|P-value:3.75E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.88|P-value:1.71E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.46|P-value:1.78E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.71|P-value:8.07E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.18|P-value:5.35E-6 ID:SGTC_3074|Compound:9116018|FD-Score:4.43|P-value:8.48E-5 ID:SGTC_3098|Compound:9119039|FD-Score:4.95|P-value:1.32E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.67|P-value:9.08E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.64|P-value:9.78E-4 ID:SGTC_3232|Compound:9132874|FD-Score:5.03|P-value:9.58E-6 ID:SGTC_3266|Compound:9136860|FD-Score:9.03|P-value:8.45E-15 ID:SGTC_3269|Compound:9137823|FD-Score:4.09|P-value:2.56E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.91|P-value:1.52E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.14|P-value:2.20E-4 ID:SGTC_3311|Compound:9131146|FD-Score:11.00|P-value:4.03E-21 ID:SGTC_33|Compound:0986-0033|FD-Score:4.38|P-value:9.85E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:5.01|P-value:1.04E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:5.62|P-value:9.06E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:9.53|P-value:2.81E-16 ID:SGTC_157|Compound:1348-1695|FD-Score:4.04|P-value:3.00E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.28|P-value:3.70E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.00|P-value:8.85E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.94|P-value:4.14E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.81|P-value:3.71E-9 ID:SGTC_347|Compound:4534-1311|FD-Score:3.97|P-value:3.70E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:9.02|P-value:8.92E-15 ID:SGTC_439|Compound:amiodarone|FD-Score:5.42|P-value:2.09E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.29|P-value:3.54E-6 ID:SGTC_447|Compound:ml7|FD-Score:4.78|P-value:2.49E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.99|P-value:1.81E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:8.90|P-value:2.00E-14 ID:SGTC_550|Compound:4123-0385|FD-Score:4.04|P-value:3.01E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.76|P-value:2.54E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:5.55|P-value:1.20E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:4.63|P-value:4.16E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.64|P-value:9.69E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.51|P-value:6.41E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:5.52|P-value:1.35E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.89|P-value:2.37E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.03|P-value:3.00E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-4.28|P-value:1.35E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-4.34|P-value:1.13E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.07|P-value:2.77E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.75|P-value:7.15E-4 ID:SGTC_1640|Compound:st009078|FD-Score:4.40|P-value:9.37E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-5.81|P-value:3.91E-7 ID:SGTC_1674|Compound:st016616|FD-Score:-5.27|P-value:3.66E-6 ID:SGTC_1677|Compound:st019204|FD-Score:-4.02|P-value:3.07E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:7.54|P-value:7.57E-11 ID:SGTC_1683|Compound:st010134|FD-Score:7.73|P-value:2.53E-11 ID:SGTC_1687|Compound:st020778|FD-Score:5.01|P-value:1.05E-5 ID:SGTC_1712|Compound:st032288|FD-Score:13.10|P-value:5.10E-29 ID:SGTC_1760|Compound:st045453|FD-Score:10.30|P-value:1.03E-18 ID:SGTC_1800|Compound:st050079|FD-Score:5.23|P-value:4.44E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.36|P-value:2.69E-6 ID:SGTC_1803|Compound:st050068|FD-Score:7.13|P-value:6.95E-10 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.38|P-value:1.85E-10 ID:SGTC_2036|Compound:5160441|FD-Score:4.73|P-value:2.98E-5 ID:SGTC_2393|Compound:9031399|FD-Score:7.44|P-value:1.33E-10 ID:SGTC_2397|Compound:5161689|FD-Score:3.95|P-value:4.04E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.38|P-value:9.85E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.71|P-value:8.20E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-4.81|P-value:2.13E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.34|P-value:1.14E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.43|P-value:8.35E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.08|P-value:2.69E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.84|P-value:1.96E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.83|P-value:5.72E-4 ID:SGTC_2836|Compound:9010338|FD-Score:5.18|P-value:5.40E-6 ID:SGTC_2845|Compound:9003024|FD-Score:8.63|P-value:1.15E-13 ID:SGTC_2852|Compound:9023854|FD-Score:3.92|P-value:4.41E-4 ID:SGTC_2970|Compound:9090938|FD-Score:5.35|P-value:2.78E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.97|P-value:3.75E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.88|P-value:1.71E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.46|P-value:1.78E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.71|P-value:8.07E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.18|P-value:5.35E-6 ID:SGTC_3074|Compound:9116018|FD-Score:4.43|P-value:8.48E-5 ID:SGTC_3098|Compound:9119039|FD-Score:4.95|P-value:1.32E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.67|P-value:9.08E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.64|P-value:9.78E-4 ID:SGTC_3232|Compound:9132874|FD-Score:5.03|P-value:9.58E-6 ID:SGTC_3266|Compound:9136860|FD-Score:9.03|P-value:8.45E-15 ID:SGTC_3269|Compound:9137823|FD-Score:4.09|P-value:2.56E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.91|P-value:1.52E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.14|P-value:2.20E-4 ID:SGTC_3311|Compound:9131146|FD-Score:11.00|P-value:4.03E-21

Top fitness defect scores for YER119C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1712 st032288 13.10 53.4 µM 5.10E-29 calcium & mitochondrial duress 4 2.03E-39
2 SGTC_3311 9131146 11.00 2.9 µM 4.03E-21 cell wall 14 1.63E-28
3 SGTC_1760 st045453 10.30 10.4 µM 1.03E-18 NEO1-PIK1 33 3.40E-25
4 SGTC_221 trifluoperazine 10.00 10.3 µM 8.85E-18 NEO1-PIK1 60 6.66E-24
5 SGTC_146 3448-8650 9.53 53.1 µM 2.81E-16 NEO1-PIK1 19 7.85E-22
6 SGTC_3266 9136860 9.03 49.5 µM 8.45E-15 cell wall 9 8.57E-20
7 SGTC_422 cantharidin 9.02 155.0 µM 8.92E-15 cell wall signaling 6 9.23E-20
8 SGTC_528 3492-0019 8.90 172.0 µM 2.00E-14 calcium & mitochondrial duress 54 2.81E-19
9 SGTC_2845 9003024 8.63 43.0 µM 1.15E-13 amide catabolism 4 3.15E-18
10 SGTC_1683 st010134 7.73 710.0 nM 2.53E-11 1 5.27E-15
11 SGTC_1679 4130-1276 7.54 6.7 µM 7.57E-11 Golgi 15 2.38E-14
12 SGTC_2393 9031399 7.44 185.9 µM 1.33E-10 RNA processing & uracil transport 3 5.17E-14
13 SGTC_1873 rapamycin 7.38 2.0 nM 1.85E-10 16 8.17E-14
14 SGTC_1803 st050068 7.13 52.4 µM 6.95E-10 NEO1-PIK1 53 5.04E-13
15 SGTC_1055 3448-0672 6.89 86.0 µM 2.37E-9 6 2.72E-12
16 SGTC_266 formosanin C 6.81 406.0 nM 3.71E-9 sphingolipid biosynthesis & PDR1 17 5.04E-12
17 SGTC_467 ro 31-8220 5.99 72.8 µM 1.81E-7 calcium & mitochondrial duress 29 1.05E-9
18 SGTC_75 0159-0059 5.62 199.0 µM 9.06E-7 fatty acid desaturase (OLE1) 7 9.55E-9
19 SGTC_582 0987-0078 5.55 156.0 µM 1.20E-6 calcium & mitochondrial duress 28 1.40E-8
20 SGTC_1008 4106-0037 5.52 6.0 µM 1.35E-6 PDR1 7 1.66E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.436 3.81E-156 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.414 2.40E-139 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.315 9.92E-78 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.291 2.57E-66 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.289 8.31E-66 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.281 4.40E-62 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.271 2.13E-57 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.263 3.35E-54 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.263 4.24E-54 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.262 6.19E-54 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.257 1.04E-51 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.256 2.33E-51 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.256 2.17E-51 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.245 4.82E-47 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.239 5.85E-45 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin