YER122C / GLO3

ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER122C / GLO3

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:5.14|P-value:1.83E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.83|P-value:7.51E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.92|P-value:5.37E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.40|P-value:6.88E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.63|P-value:2.09E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.36|P-value:5.85E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:7.38|P-value:1.41E-13 ID:SGTC_331|Compound:k048-0133|FD-Score:4.18|P-value:1.81E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.13|P-value:9.45E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.45|P-value:5.36E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.15|P-value:9.21E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.27|P-value:6.02E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.49|P-value:2.73E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.82|P-value:8.03E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:5.90|P-value:2.58E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:3.25|P-value:6.59E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.59|P-value:1.96E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.36|P-value:4.36E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.31|P-value:7.61E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:7.25|P-value:3.68E-13 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.37|P-value:4.26E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.42|P-value:6.10E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.63|P-value:2.36E-6 ID:SGTC_1623|Compound:st003709|FD-Score:5.08|P-value:2.48E-7 ID:SGTC_1624|Compound:st003710|FD-Score:3.91|P-value:5.43E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.52|P-value:2.53E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.05|P-value:3.00E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.79|P-value:8.95E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.25|P-value:6.46E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.64|P-value:2.07E-6 ID:SGTC_2029|Compound:5175081|FD-Score:4.57|P-value:3.09E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.47|P-value:3.05E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-7.74|P-value:8.84E-15 ID:SGTC_2183|Compound:6420625|FD-Score:4.22|P-value:1.50E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:10.00|P-value:1.96E-23 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.74|P-value:1.10E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.51|P-value:3.84E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.54|P-value:2.33E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.24|P-value:6.56E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-9.90|P-value:5.34E-23 ID:SGTC_2919|Compound:7978188|FD-Score:-5.54|P-value:2.04E-8 ID:SGTC_2944|Compound:9067346|FD-Score:4.22|P-value:1.52E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.81|P-value:8.31E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.50|P-value:4.23E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.91|P-value:5.37E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-5.01|P-value:3.40E-7 ID:SGTC_3076|Compound:9116187|FD-Score:3.90|P-value:5.65E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.55|P-value:2.19E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.25|P-value:6.34E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:5.14|P-value:1.83E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.83|P-value:7.51E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.92|P-value:5.37E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.40|P-value:6.88E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.63|P-value:2.09E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.36|P-value:5.85E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:7.38|P-value:1.41E-13 ID:SGTC_331|Compound:k048-0133|FD-Score:4.18|P-value:1.81E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.13|P-value:9.45E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.45|P-value:5.36E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.15|P-value:9.21E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.27|P-value:6.02E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.49|P-value:2.73E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.82|P-value:8.03E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:5.90|P-value:2.58E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:3.25|P-value:6.59E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.59|P-value:1.96E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.36|P-value:4.36E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.31|P-value:7.61E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:7.25|P-value:3.68E-13 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.37|P-value:4.26E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.42|P-value:6.10E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.63|P-value:2.36E-6 ID:SGTC_1623|Compound:st003709|FD-Score:5.08|P-value:2.48E-7 ID:SGTC_1624|Compound:st003710|FD-Score:3.91|P-value:5.43E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.52|P-value:2.53E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.05|P-value:3.00E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.79|P-value:8.95E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.25|P-value:6.46E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.64|P-value:2.07E-6 ID:SGTC_2029|Compound:5175081|FD-Score:4.57|P-value:3.09E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.47|P-value:3.05E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-7.74|P-value:8.84E-15 ID:SGTC_2183|Compound:6420625|FD-Score:4.22|P-value:1.50E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:10.00|P-value:1.96E-23 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.74|P-value:1.10E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.51|P-value:3.84E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.54|P-value:2.33E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.24|P-value:6.56E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-9.90|P-value:5.34E-23 ID:SGTC_2919|Compound:7978188|FD-Score:-5.54|P-value:2.04E-8 ID:SGTC_2944|Compound:9067346|FD-Score:4.22|P-value:1.52E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.81|P-value:8.31E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.50|P-value:4.23E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.91|P-value:5.37E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-5.01|P-value:3.40E-7 ID:SGTC_3076|Compound:9116187|FD-Score:3.90|P-value:5.65E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.55|P-value:2.19E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.25|P-value:6.34E-4

Top fitness defect scores for YER122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2232 chlorophetanol 10.00 41.5 µM 1.96E-23 TRP & mitochondrial translation 12 6.99E-24
2 SGTC_236 1509-0011 7.63 5.3 µM 2.09E-14 256 1.13E-14
3 SGTC_310 1273-0058 7.38 1.1 µM 1.41E-13 mitochondrial stress 106 7.94E-14
4 SGTC_1465 k213-0056 7.25 144.0 µM 3.68E-13 DNA intercalators 1 2.11E-13
5 SGTC_791 1348-1292 5.90 225.0 µM 2.58E-9 10 1.77E-9
6 SGTC_275 trichlorophene 5.36 5.7 µM 5.85E-8 mitochondrial stress 147 4.26E-8
7 SGTC_1306 1185-0270 5.31 9.0 µM 7.61E-8 Golgi 35 5.58E-8
8 SGTC_3 0833-0587 5.14 95.6 µM 1.83E-7 redox potentiating 13 1.37E-7
9 SGTC_1623 st003709 5.08 20.3 µM 2.48E-7 calcium & mitochondrial duress 29 1.87E-7
10 SGTC_1622 st003707 4.63 19.4 µM 2.36E-6 calcium & mitochondrial duress 24 1.85E-6
11 SGTC_2029 5175081 4.57 200.0 µM 3.09E-6 6 2.44E-6
12 SGTC_2991 9074669 4.50 71.4 µM 4.23E-6 azole & statin 44 3.36E-6
13 SGTC_625 k213-0058 4.45 121.0 µM 5.36E-6 translation 73 4.28E-6
14 SGTC_1480 1070-0044 4.42 41.2 µM 6.10E-6 9 4.88E-6
15 SGTC_173 1273-0061 4.40 2.7 µM 6.88E-6 mitochondrial stress 169 5.52E-6
16 SGTC_365 0121-0052 4.28 13.6 µM 1.15E-5 mitochondrial response to ROS 46 9.29E-6
17 SGTC_2183 6420625 4.22 130.5 µM 1.50E-5 mitochondrial processes 43 1.22E-5
18 SGTC_2944 9067346 4.22 25.6 µM 1.52E-5 16 1.24E-5
19 SGTC_331 k048-0133 4.18 24.5 µM 1.81E-5 RSC & ERG11 6 1.48E-5
20 SGTC_157 1348-1695 3.92 65.8 µM 5.37E-5 iron homeostasis 74 4.49E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.397 6.35E-127 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.396 1.76E-126 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.390 2.48E-122 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.381 1.51E-115 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.376 4.92E-113 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.374 1.18E-111 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.372 7.18E-111 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.371 3.77E-110 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.370 1.78E-109 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.368 2.99E-108 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.368 5.09E-108 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.366 4.56E-107 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.366 7.71E-107 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.359 6.77E-103 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.354 1.27E-99 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress