YER124C / DSE1

Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER124C / DSE1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.38|P-value:8.18E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.42|P-value:7.27E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.89|P-value:1.46E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.17|P-value:5.26E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.54|P-value:6.06E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.43|P-value:6.92E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.82|P-value:2.33E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.55|P-value:4.71E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.48|P-value:7.20E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.61|P-value:4.83E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.47|P-value:6.15E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:6.00|P-value:1.32E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.08|P-value:9.22E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.46|P-value:7.86E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.36|P-value:2.52E-5 ID:SGTC_1773|Compound:st048542|FD-Score:-3.54|P-value:6.01E-4 ID:SGTC_1992|Compound:st073643|FD-Score:5.23|P-value:6.08E-7 ID:SGTC_2016|Compound:5121758|FD-Score:-4.10|P-value:8.54E-5 ID:SGTC_2041|Compound:5107442|FD-Score:-3.65|P-value:4.12E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.90|P-value:1.42E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.37|P-value:8.53E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.94|P-value:1.23E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.23|P-value:4.27E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.87|P-value:1.62E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.00|P-value:9.89E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.63|P-value:3.59E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.99|P-value:2.40E-6 ID:SGTC_2556|Compound:citropten|FD-Score:-3.46|P-value:7.72E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.90|P-value:1.43E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.29|P-value:3.30E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.44|P-value:8.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.32|P-value:9.99E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.45|P-value:1.76E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.47|P-value:6.27E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.67|P-value:3.93E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.48|P-value:6.03E-4 ID:SGTC_3138|Compound:9097216|FD-Score:4.29|P-value:3.37E-5 ID:SGTC_3189|Compound:9110682|FD-Score:9.81|P-value:5.21E-20 ID:SGTC_3198|Compound:9112019|FD-Score:4.87|P-value:3.07E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.36|P-value:8.90E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.38|P-value:8.18E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.42|P-value:7.27E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.89|P-value:1.46E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.17|P-value:5.26E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.54|P-value:6.06E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.43|P-value:6.92E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.82|P-value:2.33E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.55|P-value:4.71E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.48|P-value:7.20E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.61|P-value:4.83E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.47|P-value:6.15E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:6.00|P-value:1.32E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.08|P-value:9.22E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.46|P-value:7.86E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.36|P-value:2.52E-5 ID:SGTC_1773|Compound:st048542|FD-Score:-3.54|P-value:6.01E-4 ID:SGTC_1992|Compound:st073643|FD-Score:5.23|P-value:6.08E-7 ID:SGTC_2016|Compound:5121758|FD-Score:-4.10|P-value:8.54E-5 ID:SGTC_2041|Compound:5107442|FD-Score:-3.65|P-value:4.12E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.90|P-value:1.42E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.37|P-value:8.53E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.94|P-value:1.23E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.23|P-value:4.27E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.87|P-value:1.62E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.00|P-value:9.89E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.63|P-value:3.59E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.99|P-value:2.40E-6 ID:SGTC_2556|Compound:citropten|FD-Score:-3.46|P-value:7.72E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.90|P-value:1.43E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.29|P-value:3.30E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.44|P-value:8.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.32|P-value:9.99E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.45|P-value:1.76E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.47|P-value:6.27E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.67|P-value:3.93E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.48|P-value:6.03E-4 ID:SGTC_3138|Compound:9097216|FD-Score:4.29|P-value:3.37E-5 ID:SGTC_3189|Compound:9110682|FD-Score:9.81|P-value:5.21E-20 ID:SGTC_3198|Compound:9112019|FD-Score:4.87|P-value:3.07E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.36|P-value:8.90E-4

Top fitness defect scores for YER124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3189 9110682 9.81 49.5 µM 5.21E-20 1 4.98E-23
2 SGTC_1167 k781-0610 6.00 148.0 µM 1.32E-8 RNA processing & uracil transport 2 1.00E-9
3 SGTC_1992 st073643 5.23 23.3 µM 6.08E-7 mitochondrial processes 2 8.58E-8
4 SGTC_3198 9112019 4.87 49.5 µM 3.07E-6 mitochondrial processes 4 5.62E-7
5 SGTC_2920 7982904 4.45 15.8 µM 1.76E-5 11 4.26E-6
6 SGTC_1580 hydrocortisone 21-hemisuccinate 4.36 43.2 µM 2.52E-5 16 6.44E-6
7 SGTC_2573 2',4'-dihydroxychalcone 4.29 15.0 µM 3.30E-5 38 8.81E-6
8 SGTC_3138 9097216 4.29 49.5 µM 3.37E-5 11 9.02E-6
9 SGTC_2241 6772625 4.23 37.8 µM 4.27E-5 19 1.19E-5
10 SGTC_385 1494-0393 4.17 12.4 µM 5.26E-5 15 1.51E-5
11 SGTC_2336 9001819 4.00 198.7 µM 9.89E-5 heme biosynthesis & mitochondrial translocase 54 3.14E-5
12 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 3.94 122.8 µM 1.23E-4 9 4.04E-5
13 SGTC_2080 5212524 3.90 12.4 µM 1.42E-4 copper-dependent oxidative stress 15 4.76E-5
14 SGTC_2562 3',7'-dimethoxyflavone 3.90 64.9 µM 1.43E-4 33 4.79E-5
15 SGTC_332 4112-0506 3.89 40.9 µM 1.46E-4 26 4.93E-5
16 SGTC_2255 7941087 3.87 197.4 µM 1.62E-4 34 5.54E-5
17 SGTC_2339 9000433 3.63 200.0 µM 3.59E-4 46 1.39E-4
18 SGTC_954 1189-0853 3.55 2.9 µM 4.71E-4 endomembrane recycling 53 1.91E-4
19 SGTC_3065 9113888 3.48 49.5 µM 6.03E-4 39 2.53E-4
20 SGTC_1149 3909-7961 3.47 23.3 µM 6.15E-4 37 2.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.56E-10 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.087 4.13E-7 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.084 1.08E-6 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.084 1.15E-6 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.084 1.27E-6 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.080 3.74E-6 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.076 9.51E-6 YKL204W EAP1 hom eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
0.074 2.00E-5 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.071 3.69E-5 YIR022W SEC11 het 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
0.071 4.24E-5 YGR007W ECT1 hom Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
0.071 4.32E-5 YPR101W SNT309 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
0.067 1.01E-4 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.067 1.07E-4 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.065 1.80E-4 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.064 2.08E-4 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments