YER126C / NSA2

Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER126C / NSA2

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.00|P-value:7.91E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.30|P-value:2.90E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:4.22|P-value:5.20E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.15|P-value:4.53E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-2.93|P-value:9.96E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:3.13|P-value:5.58E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.93|P-value:2.08E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:5.18|P-value:3.10E-8 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.68|P-value:6.22E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:3.00|P-value:8.86E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.47|P-value:1.26E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.45|P-value:1.57E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.19|P-value:4.42E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.04|P-value:7.66E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.90|P-value:1.31E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:3.86|P-value:2.76E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.05|P-value:7.37E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.09|P-value:6.39E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.11|P-value:6.01E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-2.94|P-value:9.82E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.84|P-value:3.03E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.60|P-value:8.63E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.15|P-value:4.45E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.79|P-value:3.25E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-4.37|P-value:2.10E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.91|P-value:1.89E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.82|P-value:3.40E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.61|P-value:8.44E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.36|P-value:2.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.74|P-value:4.73E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_1709|Compound:st033179|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.15|P-value:4.51E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.62|P-value:8.09E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.63|P-value:7.49E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.38|P-value:2.37E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.65|P-value:6.85E-5 ID:SGTC_2204|Compound:7233102|FD-Score:3.07|P-value:6.82E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.11|P-value:5.90E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-4.09|P-value:8.41E-6 ID:SGTC_2303|Compound:7774051|FD-Score:3.85|P-value:3.00E-5 ID:SGTC_2330|Compound:7979373|FD-Score:4.04|P-value:1.21E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-3.28|P-value:2.79E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.30|P-value:2.90E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.58|P-value:9.20E-5 ID:SGTC_2442|Compound:5158906|FD-Score:-3.22|P-value:3.48E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.32|P-value:2.32E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:-3.23|P-value:3.33E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.51|P-value:1.08E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.28|P-value:3.90E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.09|P-value:6.47E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.77|P-value:4.27E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.74|P-value:4.75E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.77|P-value:4.27E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-7.16|P-value:2.71E-14 ID:SGTC_3087|Compound:9117406|FD-Score:4.40|P-value:2.13E-6 ID:SGTC_3234|Compound:9132280|FD-Score:3.19|P-value:4.33E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.69|P-value:5.89E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.00|P-value:7.91E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.30|P-value:2.90E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:4.22|P-value:5.20E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.15|P-value:4.53E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-2.93|P-value:9.96E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:3.13|P-value:5.58E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.93|P-value:2.08E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:5.18|P-value:3.10E-8 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.68|P-value:6.22E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:3.00|P-value:8.86E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.47|P-value:1.26E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.45|P-value:1.57E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.19|P-value:4.42E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.04|P-value:7.66E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.90|P-value:1.31E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:3.86|P-value:2.76E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.05|P-value:7.37E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.09|P-value:6.39E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.11|P-value:6.01E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-2.94|P-value:9.82E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.84|P-value:3.03E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.60|P-value:8.63E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.15|P-value:4.45E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.79|P-value:3.25E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-4.37|P-value:2.10E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.91|P-value:1.89E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.82|P-value:3.40E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.61|P-value:8.44E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.36|P-value:2.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.74|P-value:4.73E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_1709|Compound:st033179|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.15|P-value:4.51E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.62|P-value:8.09E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.63|P-value:7.49E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.38|P-value:2.37E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.65|P-value:6.85E-5 ID:SGTC_2204|Compound:7233102|FD-Score:3.07|P-value:6.82E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.11|P-value:5.90E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-4.09|P-value:8.41E-6 ID:SGTC_2303|Compound:7774051|FD-Score:3.85|P-value:3.00E-5 ID:SGTC_2330|Compound:7979373|FD-Score:4.04|P-value:1.21E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-3.28|P-value:2.79E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.30|P-value:2.90E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.58|P-value:9.20E-5 ID:SGTC_2442|Compound:5158906|FD-Score:-3.22|P-value:3.48E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.32|P-value:2.32E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:-3.23|P-value:3.33E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.51|P-value:1.08E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.28|P-value:3.90E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.09|P-value:6.47E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.77|P-value:4.27E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.74|P-value:4.75E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.77|P-value:4.27E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-7.16|P-value:2.71E-14 ID:SGTC_3087|Compound:9117406|FD-Score:4.40|P-value:2.13E-6 ID:SGTC_3234|Compound:9132280|FD-Score:3.19|P-value:4.33E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.69|P-value:5.89E-5

Top fitness defect scores for YER126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_341 1486-1430 5.18 230.0 µM 3.10E-8 13 1.11E-7 0.26
2 SGTC_3087 9117406 4.40 49.5 µM 2.13E-6 1 5.32E-6 0.41
3 SGTC_1916 st067606 4.38 49.2 µM 2.37E-6 4 5.87E-6 0.23
4 SGTC_2756 carbadox 4.28 75.1 µM 3.90E-6 17 9.27E-6 0.02
5 SGTC_75 0159-0059 4.22 199.0 µM 5.20E-6 fatty acid desaturase (OLE1) 6 1.21E-5 0.00
6 SGTC_2330 7979373 4.04 200.0 µM 1.21E-5 60S ribosome export 9 2.63E-5 0.32
7 SGTC_293 4049-0273 3.93 38.5 µM 2.08E-5 4 4.29E-5 0.07
8 SGTC_765 1319-0117 3.86 244.0 µM 2.76E-5 60S ribosome export 6 5.59E-5 0.04
9 SGTC_2303 7774051 3.85 200.0 µM 3.00E-5 5 6.03E-5 0.00
10 SGTC_913 3487-1245 3.84 167.0 µM 3.03E-5 13 6.07E-5 0.39
11 SGTC_1308 1187-1617 3.82 41.4 µM 3.40E-5 fatty acid desaturase (OLE1) 10 6.76E-5 0.01
12 SGTC_2994 9053520 3.77 71.4 µM 4.27E-5 RPP1 & pyrimidine depletion 10 8.33E-5 0.02
13 SGTC_3056 9094900 3.77 49.5 µM 4.27E-5 7 8.33E-5 0.24
14 SGTC_1510 1123-0200 3.74 71.5 µM 4.73E-5 19 9.14E-5 0.20
15 SGTC_3034 9090421 3.74 49.5 µM 4.75E-5 60S ribosome export 4 9.18E-5 0.23
16 SGTC_3249 9135183 3.69 49.5 µM 5.89E-5 60S ribosome export 6 1.12E-4 0.02
17 SGTC_466 geldanamycin 3.68 89.2 µM 6.22E-5 RPP1 & pyrimidine depletion 3 1.18E-4 0.11
18 SGTC_2038 4100038 3.65 31.0 µM 6.85E-5 plasma membrane duress 19 1.29E-4 0.25
19 SGTC_1886 st057356 3.63 49.9 µM 7.49E-5 60S ribosome export 6 1.40E-4 0.03
20 SGTC_1867 st057372 3.62 64.0 µM 8.09E-5 3 1.50E-4 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.64E-11 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.114 3.37E-11 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.111 1.15E-10 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.108 3.81E-10 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.106 8.12E-10 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.105 1.08E-9 YDR373W FRQ1 het N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
0.104 1.35E-9 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.101 4.31E-9 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.099 8.33E-9 YER018C SPC25 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.099 1.08E-8 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.098 1.34E-8 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.097 1.73E-8 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.095 3.75E-8 YHR197W RIX1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
0.094 5.71E-8 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.092 9.13E-8 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication