YER130C_p

Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER130C / YER130C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.75|P-value:8.18E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.61|P-value:7.69E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:5.59|P-value:1.14E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.02|P-value:1.14E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:4.50|P-value:7.44E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.22|P-value:1.91E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.71|P-value:5.60E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.70|P-value:3.74E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.59|P-value:5.51E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.66|P-value:2.35E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.77|P-value:7.79E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-6.54|P-value:6.61E-9 ID:SGTC_429|Compound:1112-0049|FD-Score:-5.29|P-value:2.00E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.04|P-value:3.37E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.82|P-value:3.99E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-4.40|P-value:5.91E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.72|P-value:9.09E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:5.69|P-value:7.29E-7 ID:SGTC_936|Compound:3005-4620|FD-Score:3.80|P-value:7.18E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.92|P-value:4.98E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.28|P-value:1.55E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.51|P-value:7.27E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.97|P-value:1.34E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.79|P-value:7.34E-4 ID:SGTC_1531|Compound:st059297|FD-Score:5.57|P-value:1.25E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:5.02|P-value:1.11E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.02|P-value:3.60E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.69|P-value:9.85E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.94|P-value:4.63E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-4.15|P-value:1.38E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.65|P-value:4.35E-5 ID:SGTC_1783|Compound:st039459|FD-Score:5.26|P-value:4.32E-6 ID:SGTC_1790|Compound:st045711|FD-Score:-5.09|P-value:4.46E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:9.95|P-value:1.21E-17 ID:SGTC_1909|Compound:st060837|FD-Score:3.82|P-value:6.68E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.84|P-value:3.91E-7 ID:SGTC_2141|Compound:5621638|FD-Score:4.35|P-value:1.25E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.48|P-value:7.93E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.00|P-value:6.32E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.28|P-value:2.08E-6 ID:SGTC_2265|Compound:7929201|FD-Score:7.24|P-value:3.99E-10 ID:SGTC_2290|Compound:7904846|FD-Score:6.45|P-value:2.29E-8 ID:SGTC_2300|Compound:7976697|FD-Score:4.41|P-value:1.00E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.79|P-value:4.32E-9 ID:SGTC_2333|Compound:9017922|FD-Score:4.57|P-value:5.80E-5 ID:SGTC_2381|Compound:9035592|FD-Score:5.13|P-value:7.49E-6 ID:SGTC_2389|Compound:9091542|FD-Score:4.17|P-value:2.27E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.76|P-value:8.08E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-5.88|P-value:1.55E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.71|P-value:9.34E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.58|P-value:8.33E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.30|P-value:1.48E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.84|P-value:3.83E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.94|P-value:4.62E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.83|P-value:6.47E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.89|P-value:5.48E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.92|P-value:4.93E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.79|P-value:4.75E-7 ID:SGTC_3281|Compound:9140613|FD-Score:-3.56|P-value:8.71E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.75|P-value:8.18E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.61|P-value:7.69E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:5.59|P-value:1.14E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.02|P-value:1.14E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:4.50|P-value:7.44E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.22|P-value:1.91E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.71|P-value:5.60E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.70|P-value:3.74E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.59|P-value:5.51E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.66|P-value:2.35E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.77|P-value:7.79E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-6.54|P-value:6.61E-9 ID:SGTC_429|Compound:1112-0049|FD-Score:-5.29|P-value:2.00E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.04|P-value:3.37E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.82|P-value:3.99E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-4.40|P-value:5.91E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.72|P-value:9.09E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:5.69|P-value:7.29E-7 ID:SGTC_936|Compound:3005-4620|FD-Score:3.80|P-value:7.18E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.92|P-value:4.98E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.28|P-value:1.55E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.51|P-value:7.27E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.97|P-value:1.34E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.79|P-value:7.34E-4 ID:SGTC_1531|Compound:st059297|FD-Score:5.57|P-value:1.25E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:5.02|P-value:1.11E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.02|P-value:3.60E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.69|P-value:9.85E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.94|P-value:4.63E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-4.15|P-value:1.38E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.65|P-value:4.35E-5 ID:SGTC_1783|Compound:st039459|FD-Score:5.26|P-value:4.32E-6 ID:SGTC_1790|Compound:st045711|FD-Score:-5.09|P-value:4.46E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:9.95|P-value:1.21E-17 ID:SGTC_1909|Compound:st060837|FD-Score:3.82|P-value:6.68E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.84|P-value:3.91E-7 ID:SGTC_2141|Compound:5621638|FD-Score:4.35|P-value:1.25E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.48|P-value:7.93E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.00|P-value:6.32E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.28|P-value:2.08E-6 ID:SGTC_2265|Compound:7929201|FD-Score:7.24|P-value:3.99E-10 ID:SGTC_2290|Compound:7904846|FD-Score:6.45|P-value:2.29E-8 ID:SGTC_2300|Compound:7976697|FD-Score:4.41|P-value:1.00E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.79|P-value:4.32E-9 ID:SGTC_2333|Compound:9017922|FD-Score:4.57|P-value:5.80E-5 ID:SGTC_2381|Compound:9035592|FD-Score:5.13|P-value:7.49E-6 ID:SGTC_2389|Compound:9091542|FD-Score:4.17|P-value:2.27E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.76|P-value:8.08E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-5.88|P-value:1.55E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.71|P-value:9.34E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.58|P-value:8.33E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.30|P-value:1.48E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.84|P-value:3.83E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.94|P-value:4.62E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.83|P-value:6.47E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.89|P-value:5.48E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.92|P-value:4.93E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.79|P-value:4.75E-7 ID:SGTC_3281|Compound:9140613|FD-Score:-3.56|P-value:8.71E-4

Top fitness defect scores for YER130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1876 myriocin 9.95 605.0 nM 1.21E-17 8 1.26E-23
2 SGTC_2265 7929201 7.24 200.0 µM 3.99E-10 4 2.23E-13
3 SGTC_2302 7771753 6.79 200.0 µM 4.32E-9 5 5.74E-12
4 SGTC_2290 7904846 6.45 200.0 µM 2.29E-8 3 5.57E-11
5 SGTC_2966 9084041 5.84 48.0 µM 3.83E-7 7 2.59E-9
6 SGTC_2128 5255449 5.84 168.5 µM 3.91E-7 5 2.66E-9
7 SGTC_3211 9128781 5.79 49.5 µM 4.75E-7 22 3.46E-9
8 SGTC_925 2064-1272 5.69 59.6 µM 7.29E-7 4 6.22E-9
9 SGTC_50 0929-0078 5.59 56.4 µM 1.14E-6 26 1.14E-8
10 SGTC_1531 st059297 5.57 52.4 µM 1.25E-6 2 1.29E-8
11 SGTC_1783 st039459 5.26 87.5 µM 4.32E-6 Golgi 9 7.02E-8
12 SGTC_2381 9035592 5.13 200.0 µM 7.49E-6 5 1.48E-7
13 SGTC_1543 azetidyl-2-carboxylic acid 5.02 198.0 µM 1.11E-5 3 2.53E-7
14 SGTC_58 0957-0393 5.02 9.0 µM 1.14E-5 cell wall 280 2.64E-7
15 SGTC_1453 4237-0541 4.97 195.0 µM 1.34E-5 heme biosynthesis & mitochondrial translocase 12 3.29E-7
16 SGTC_179 1273-0063 4.70 6.8 µM 3.74E-5 12 1.33E-6
17 SGTC_1632 st005650 4.65 90.0 µM 4.35E-5 12 1.63E-6
18 SGTC_265 mycophenolic acid 4.59 32.9 µM 5.51E-5 RPP1 & pyrimidine depletion 7 2.25E-6
19 SGTC_2333 9017922 4.57 200.0 µM 5.80E-5 15 2.41E-6
20 SGTC_1266 0828-0227 4.51 32.9 µM 7.27E-5 13 3.28E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 1.79E-34 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.178 2.39E-25 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.116 1.64E-11 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.114 3.98E-11 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.113 4.52E-11 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.113 5.08E-11 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.112 8.38E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.099 9.77E-9 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.093 7.20E-8 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.093 7.98E-8 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.090 1.97E-7 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.92E-7 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.085 7.69E-7 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.085 9.45E-7 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.083 1.50E-6 YCR020C-A MAK31 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family