YER131W / RPS26B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER131W / RPS26B

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.81|P-value:9.03E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.79|P-value:9.98E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.39|P-value:5.89E-8 ID:SGTC_428|Compound:3448-4153|FD-Score:7.02|P-value:2.59E-12 ID:SGTC_527|Compound:4476-4215|FD-Score:3.67|P-value:1.56E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.34|P-value:5.17E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.51|P-value:4.58E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:3.90|P-value:6.40E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.53|P-value:2.57E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:5.94|P-value:2.66E-9 ID:SGTC_901|Compound:1112-0062|FD-Score:4.08|P-value:3.02E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.22|P-value:7.99E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.60|P-value:2.03E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.28|P-value:6.40E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.26|P-value:1.27E-7 ID:SGTC_1604|Compound:st002052|FD-Score:4.32|P-value:1.09E-5 ID:SGTC_1613|Compound:st002381|FD-Score:5.83|P-value:5.20E-9 ID:SGTC_1621|Compound:st003705|FD-Score:-3.67|P-value:1.60E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.15|P-value:9.81E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.67|P-value:1.59E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.96|P-value:5.42E-7 ID:SGTC_1861|Compound:st057647|FD-Score:-3.59|P-value:2.14E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.26|P-value:1.38E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-4.03|P-value:3.99E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.23|P-value:7.82E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.22|P-value:8.13E-4 ID:SGTC_2215|Compound:7188065|FD-Score:4.37|P-value:8.81E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.76|P-value:1.12E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.16|P-value:9.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.43|P-value:3.87E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.45|P-value:3.44E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.39|P-value:7.87E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.26|P-value:6.80E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.25|P-value:7.23E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.15|P-value:9.88E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.23|P-value:1.34E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.81|P-value:9.03E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.79|P-value:9.98E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.39|P-value:5.89E-8 ID:SGTC_428|Compound:3448-4153|FD-Score:7.02|P-value:2.59E-12 ID:SGTC_527|Compound:4476-4215|FD-Score:3.67|P-value:1.56E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.34|P-value:5.17E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.51|P-value:4.58E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:3.90|P-value:6.40E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.53|P-value:2.57E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:5.94|P-value:2.66E-9 ID:SGTC_901|Compound:1112-0062|FD-Score:4.08|P-value:3.02E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.22|P-value:7.99E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.60|P-value:2.03E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.28|P-value:6.40E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.26|P-value:1.27E-7 ID:SGTC_1604|Compound:st002052|FD-Score:4.32|P-value:1.09E-5 ID:SGTC_1613|Compound:st002381|FD-Score:5.83|P-value:5.20E-9 ID:SGTC_1621|Compound:st003705|FD-Score:-3.67|P-value:1.60E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.15|P-value:9.81E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.67|P-value:1.59E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.96|P-value:5.42E-7 ID:SGTC_1861|Compound:st057647|FD-Score:-3.59|P-value:2.14E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.26|P-value:1.38E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-4.03|P-value:3.99E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.23|P-value:7.82E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.22|P-value:8.13E-4 ID:SGTC_2215|Compound:7188065|FD-Score:4.37|P-value:8.81E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.76|P-value:1.12E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.16|P-value:9.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.43|P-value:3.87E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.45|P-value:3.44E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.39|P-value:7.87E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.26|P-value:6.80E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.25|P-value:7.23E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.15|P-value:9.88E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.23|P-value:1.34E-7

Top fitness defect scores for YER131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_428 3448-4153 7.02 16.5 µM 2.59E-12 TSC3-RPN4 4 1.08E-12
2 SGTC_814 3342-0569 5.94 96.0 µM 2.66E-9 4 1.42E-9
3 SGTC_1613 st002381 5.83 52.1 µM 5.20E-9 4 2.85E-9
4 SGTC_422 cantharidin 5.39 155.0 µM 5.89E-8 cell wall signaling 25 3.52E-8
5 SGTC_3334 9142812 5.23 21.9 µM 1.34E-7 9 8.27E-8
6 SGTC_1836 st055642 4.96 81.0 µM 5.42E-7 7 3.50E-7
7 SGTC_536 3852-0578 4.51 10.6 µM 4.58E-6 17 3.19E-6
8 SGTC_2950 9072895 4.39 21.5 µM 7.87E-6 27 5.59E-6
9 SGTC_2215 7188065 4.37 200.0 µM 8.81E-6 3 6.28E-6
10 SGTC_1604 st002052 4.32 72.4 µM 1.09E-5 TSC3-RPN4 20 7.86E-6
11 SGTC_1953 st076800 4.26 12.1 µM 1.38E-5 40 1.00E-5
12 SGTC_901 1112-0062 4.08 60.1 µM 3.02E-5 8 2.24E-5
13 SGTC_625 k213-0058 3.90 121.0 µM 6.40E-5 translation 111 4.89E-5
14 SGTC_118 0083-0097 3.81 135.3 µM 9.03E-5 translation 150 6.97E-5
15 SGTC_6 0844-0013 3.77 19.8 µM 1.04E-4 103 8.11E-5
16 SGTC_800 3448-7362 3.70 155.0 µM 1.39E-4 translation 187 1.09E-4
17 SGTC_527 4476-4215 3.67 268.0 µM 1.56E-4 PDR1 46 1.23E-4
18 SGTC_1109 tnp00067 3.60 928.3 nM 2.03E-4 22 1.61E-4
19 SGTC_740 k014-0057 3.53 261.0 µM 2.57E-4 39 2.06E-4
20 SGTC_2755 lomerizine 3.45 42.7 µM 3.44E-4 38 2.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.23E-15 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.128 1.29E-13 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.122 1.61E-12 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.119 4.88E-12 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.119 5.10E-12 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.118 7.75E-12 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.117 1.02E-11 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.110 1.48E-10 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.109 2.09E-10 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.107 4.32E-10 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.105 9.25E-10 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.104 1.36E-9 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.103 2.61E-9 YOR235W_d IRC13_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
0.102 3.87E-9 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.101 3.87E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2