YER132C / PMD1

Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YER132C / PMD1

Click on Significant Values for Screen Details ID:SGTC_185|Compound:k048-0037|FD-Score:3.27|P-value:7.41E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.55|P-value:2.74E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.85|P-value:1.24E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:4.34|P-value:1.25E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.58|P-value:4.21E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:4.33|P-value:1.26E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.23|P-value:8.48E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.67|P-value:2.83E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.08|P-value:3.57E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:3.31|P-value:6.51E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.64|P-value:2.08E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.33|P-value:6.15E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.37|P-value:5.34E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.48|P-value:3.61E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.94|P-value:7.93E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.34|P-value:5.81E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.97|P-value:5.76E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.33|P-value:1.26E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.34|P-value:5.71E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.32|P-value:6.27E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.67|P-value:1.79E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.66|P-value:1.83E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.18|P-value:9.86E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.37|P-value:5.30E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.32|P-value:6.28E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.58|P-value:2.57E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.23|P-value:8.36E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.72|P-value:1.50E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.21|P-value:9.15E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.96|P-value:7.26E-7 ID:SGTC_2344|Compound:7990960|FD-Score:3.61|P-value:2.27E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.24|P-value:8.07E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.21|P-value:8.86E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.24|P-value:8.19E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.84|P-value:9.46E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.01|P-value:4.90E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-5.70|P-value:1.57E-8 ID:SGTC_3118|Compound:9124250|FD-Score:-4.84|P-value:1.30E-6 ID:SGTC_185|Compound:k048-0037|FD-Score:3.27|P-value:7.41E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.55|P-value:2.74E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.85|P-value:1.24E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:4.34|P-value:1.25E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.58|P-value:4.21E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:4.33|P-value:1.26E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.23|P-value:8.48E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.67|P-value:2.83E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.08|P-value:3.57E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:3.31|P-value:6.51E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.64|P-value:2.08E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.33|P-value:6.15E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.37|P-value:5.34E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.48|P-value:3.61E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.94|P-value:7.93E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.34|P-value:5.81E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.97|P-value:5.76E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.33|P-value:1.26E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.34|P-value:5.71E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.32|P-value:6.27E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.67|P-value:1.79E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.66|P-value:1.83E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.18|P-value:9.86E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.37|P-value:5.30E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.32|P-value:6.28E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.58|P-value:2.57E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.23|P-value:8.36E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.72|P-value:1.50E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.21|P-value:9.15E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.96|P-value:7.26E-7 ID:SGTC_2344|Compound:7990960|FD-Score:3.61|P-value:2.27E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.24|P-value:8.07E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.21|P-value:8.86E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.24|P-value:8.19E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.84|P-value:9.46E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.01|P-value:4.90E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-5.70|P-value:1.57E-8 ID:SGTC_3118|Compound:9124250|FD-Score:-4.84|P-value:1.30E-6

Top fitness defect scores for YER132C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2309 7664088 4.96 163.9 µM 7.26E-7 10 3.60E-7
2 SGTC_1000 4048-0884 4.94 8.7 µM 7.93E-7 copper-dependent oxidative stress 17 3.95E-7
3 SGTC_207 4185-0010 4.85 4.5 µM 1.24E-6 endomembrane recycling 58 6.32E-7
4 SGTC_604 1000-0114 4.67 314.0 µM 2.83E-6 8 1.51E-6
5 SGTC_384 k007-0144 4.58 5.2 µM 4.21E-6 ERAD & cell cycle 43 2.31E-6
6 SGTC_345 1362-0200 4.34 395.0 µM 1.25E-5 9 7.29E-6
7 SGTC_1378 2093-0007 4.33 380.0 nM 1.26E-5 13 7.33E-6
8 SGTC_592 k241-0073 4.33 46.5 µM 1.26E-5 16 7.34E-6
9 SGTC_607 4491-0986 4.08 66.8 µM 3.57E-5 heme requiring 26 2.21E-5
10 SGTC_2636 apigenin dimethyl ether 4.01 100.0 µM 4.90E-5 47 3.08E-5
11 SGTC_2611 pyromycin 3.84 23.9 µM 9.46E-5 29 6.17E-5
12 SGTC_1977 st070720 3.72 65.3 µM 1.50E-4 15 1.00E-4
13 SGTC_1580 hydrocortisone 21-hemisuccinate 3.67 43.2 µM 1.79E-4 23 1.21E-4
14 SGTC_1623 st003709 3.66 20.3 µM 1.83E-4 calcium & mitochondrial duress 88 1.24E-4
15 SGTC_2344 7990960 3.61 77.0 µM 2.27E-4 34 1.55E-4
16 SGTC_192 3455-0609 3.55 60.9 µM 2.74E-4 20 1.90E-4
17 SGTC_980 1473-0395 3.48 201.0 µM 3.61E-4 21 2.53E-4
18 SGTC_789 1309-1135 3.45 70.6 µM 3.91E-4 ERG2 50 2.76E-4
19 SGTC_1648 st011736 3.37 69.8 µM 5.30E-4 PDR1 26 3.80E-4
20 SGTC_1422 4031-0024 3.34 15.5 µM 5.71E-4 iron homeostasis 35 4.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.74E-10 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.099 8.39E-9 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.59E-9 YAL067C SEO1 hom Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
0.087 4.74E-7 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.087 4.77E-7 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.080 3.57E-6 YMR243C ZRC1 hom Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication
0.080 3.89E-6 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.078 5.50E-6 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.077 8.87E-6 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.076 1.18E-5 YDL085C-A_p YDL085C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.075 1.29E-5 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.073 2.59E-5 YDR077W SED1 hom Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
0.071 3.77E-5 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.069 6.78E-5 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.068 7.61E-5 YLR334C_d YLR334C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here