YER134C

Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YER134C / YER134C

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.82|P-value:5.87E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:4.30|P-value:7.17E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.14|P-value:7.69E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.56|P-value:1.05E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.23|P-value:5.55E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.95|P-value:3.06E-7 ID:SGTC_194|Compound:1486-1323|FD-Score:3.92|P-value:3.84E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.14|P-value:7.79E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:4.59|P-value:1.83E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.48|P-value:2.23E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.34|P-value:6.04E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.44|P-value:2.60E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.58|P-value:1.98E-6 ID:SGTC_665|Compound:3914-0008|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.46|P-value:2.46E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.47|P-value:2.33E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.73|P-value:8.50E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.10|P-value:8.88E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.58|P-value:1.53E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.83|P-value:5.74E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.50|P-value:2.10E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.63|P-value:1.52E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.78|P-value:7.04E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.19|P-value:6.55E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.60|P-value:1.40E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.35|P-value:3.70E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.44|P-value:2.63E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.69|P-value:1.13E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.40|P-value:3.05E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.11|P-value:8.67E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.87|P-value:4.70E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.17|P-value:7.01E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.81|P-value:6.20E-7 ID:SGTC_1990|Compound:st072050|FD-Score:4.52|P-value:2.63E-6 ID:SGTC_1998|Compound:st075797|FD-Score:-3.07|P-value:9.84E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.69|P-value:9.83E-5 ID:SGTC_2031|Compound:5180455|FD-Score:3.42|P-value:2.85E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.11|P-value:8.51E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.60|P-value:1.79E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.37|P-value:3.37E-4 ID:SGTC_2471|Compound:5466956|FD-Score:-3.56|P-value:1.64E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.86|P-value:4.98E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.55|P-value:1.70E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.92|P-value:3.80E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:4.39|P-value:4.80E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.11|P-value:8.46E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.30|P-value:4.32E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.78|P-value:7.04E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.62|P-value:1.34E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.79|P-value:6.69E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-3.62|P-value:1.33E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.10|P-value:8.89E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.82|P-value:5.87E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:4.30|P-value:7.17E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.14|P-value:7.69E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.56|P-value:1.05E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.23|P-value:5.55E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.95|P-value:3.06E-7 ID:SGTC_194|Compound:1486-1323|FD-Score:3.92|P-value:3.84E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.14|P-value:7.79E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:4.59|P-value:1.83E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.48|P-value:2.23E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.34|P-value:6.04E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.44|P-value:2.60E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.58|P-value:1.98E-6 ID:SGTC_665|Compound:3914-0008|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.46|P-value:2.46E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.47|P-value:2.33E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.73|P-value:8.50E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.10|P-value:8.88E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.58|P-value:1.53E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.83|P-value:5.74E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.50|P-value:2.10E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.63|P-value:1.52E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.78|P-value:7.04E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.19|P-value:6.55E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.60|P-value:1.40E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.35|P-value:3.70E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.44|P-value:2.63E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.69|P-value:1.13E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.40|P-value:3.05E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.11|P-value:8.67E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.87|P-value:4.70E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.17|P-value:7.01E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.81|P-value:6.20E-7 ID:SGTC_1990|Compound:st072050|FD-Score:4.52|P-value:2.63E-6 ID:SGTC_1998|Compound:st075797|FD-Score:-3.07|P-value:9.84E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.69|P-value:9.83E-5 ID:SGTC_2031|Compound:5180455|FD-Score:3.42|P-value:2.85E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.11|P-value:8.51E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.60|P-value:1.79E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.37|P-value:3.37E-4 ID:SGTC_2471|Compound:5466956|FD-Score:-3.56|P-value:1.64E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.86|P-value:4.98E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.55|P-value:1.70E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.92|P-value:3.80E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:4.39|P-value:4.80E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.11|P-value:8.46E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.30|P-value:4.32E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.78|P-value:7.04E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.62|P-value:1.34E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.79|P-value:6.69E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-3.62|P-value:1.33E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.10|P-value:8.89E-4

Top fitness defect scores for YER134C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 4.95 24.7 µM 3.06E-7 32 3.75E-7
2 SGTC_1956 st077085 4.81 54.0 µM 6.20E-7 9 7.52E-7
3 SGTC_1766 st045414 4.69 44.8 µM 1.13E-6 RPP1 & pyrimidine depletion 14 1.36E-6
4 SGTC_1513 0337-0559 4.63 19.0 µM 1.52E-6 9 1.82E-6
5 SGTC_2350 9023895 4.60 38.9 µM 1.79E-6 ergosterol biosynthesis 20 2.14E-6
6 SGTC_296 1222-0039 4.59 74.9 µM 1.83E-6 7 2.18E-6
7 SGTC_493 zm226600 4.58 134.0 µM 1.98E-6 mitochondrial processes 8 2.36E-6
8 SGTC_1990 st072050 4.52 59.8 µM 2.63E-6 8 3.12E-6
9 SGTC_2722 naftopidil 4.39 47.2 µM 4.80E-6 5 5.64E-6
10 SGTC_42 0133-0086 4.30 60.6 µM 7.17E-6 20 8.38E-6
11 SGTC_665 3914-0008 4.12 307.0 µM 1.64E-5 17 1.89E-5
12 SGTC_194 1486-1323 3.92 56.9 µM 3.84E-5 21 4.37E-5
13 SGTC_1941 st076221 3.87 61.8 µM 4.70E-5 sphingolipid biosynthesis & PDR1 84 5.34E-5
14 SGTC_2513 baicalein 3.86 25.6 µM 4.98E-5 calcium & mitochondrial duress 30 5.65E-5
15 SGTC_1396 3511-0007 3.83 98.6 µM 5.74E-5 mitochondrial processes 15 6.50E-5
16 SGTC_20 0481-0013 3.82 4.9 µM 5.87E-5 27 6.64E-5
17 SGTC_3056 9094900 3.79 49.5 µM 6.69E-5 28 7.56E-5
18 SGTC_3045 9092950 3.78 49.5 µM 7.04E-5 22 7.95E-5
19 SGTC_788 1182-0090 3.73 188.0 µM 8.50E-5 endomembrane recycling 86 9.57E-5
20 SGTC_1999 st074831 3.69 12.5 µM 9.83E-5 plasma membrane duress 40 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.72E-13 YKL157W APE2 hom Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication
0.116 1.97E-11 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.111 1.09E-10 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.088 3.35E-7 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.077 7.64E-6 YKL107W_p YKL107W_p hom Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
0.075 1.25E-5 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.075 1.25E-5 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.075 1.31E-5 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.073 2.34E-5 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.071 3.59E-5 YCL036W GFD2 hom Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication
0.071 3.80E-5 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.071 4.28E-5 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.069 6.81E-5 YPL039W_p YPL039W_p hom Putative protein of unknown function; YPL039W is not an essential gene
0.069 7.07E-5 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.068 7.19E-5 YBR018C GAL7 hom Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism