YER135C_d

Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YER135C / YER135C

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.86|P-value:2.20E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.91|P-value:1.87E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.79|P-value:7.28E-8 ID:SGTC_110|Compound:0850-0284|FD-Score:-4.67|P-value:1.53E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.46|P-value:3.37E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:4.55|P-value:1.76E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:3.71|P-value:3.64E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.82|P-value:3.33E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.00|P-value:1.83E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:4.22|P-value:6.17E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:4.12|P-value:8.78E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.87|P-value:2.09E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.33|P-value:4.05E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.49|P-value:9.51E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-4.11|P-value:1.24E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.07|P-value:1.07E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:6.65|P-value:8.32E-10 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.66|P-value:1.39E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.69|P-value:3.93E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.61|P-value:1.41E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.52|P-value:6.67E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.49|P-value:2.19E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.65|P-value:5.73E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.08|P-value:1.01E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.58|P-value:1.57E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.40|P-value:9.71E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.59|P-value:7.00E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.30|P-value:4.50E-5 ID:SGTC_1772|Compound:st048439|FD-Score:-4.00|P-value:1.81E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.81|P-value:3.47E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.69|P-value:3.83E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-3.60|P-value:6.75E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.54|P-value:6.16E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.53|P-value:6.41E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.51|P-value:8.91E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.90|P-value:1.91E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.01|P-value:1.32E-4 ID:SGTC_2332|Compound:7982454|FD-Score:6.59|P-value:1.14E-9 ID:SGTC_2461|Compound:5755302|FD-Score:3.57|P-value:5.67E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.57|P-value:2.23E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.23|P-value:8.08E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.83|P-value:2.44E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.54|P-value:6.23E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.84|P-value:3.10E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-4.59|P-value:2.05E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.43|P-value:8.72E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.57|P-value:2.27E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.45|P-value:8.28E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.44|P-value:8.55E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.86|P-value:2.20E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.91|P-value:1.87E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.79|P-value:7.28E-8 ID:SGTC_110|Compound:0850-0284|FD-Score:-4.67|P-value:1.53E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.46|P-value:3.37E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:4.55|P-value:1.76E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:3.71|P-value:3.64E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.82|P-value:3.33E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.00|P-value:1.83E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:4.22|P-value:6.17E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:4.12|P-value:8.78E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.87|P-value:2.09E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.33|P-value:4.05E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.49|P-value:9.51E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-4.11|P-value:1.24E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.07|P-value:1.07E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:6.65|P-value:8.32E-10 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.66|P-value:1.39E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.69|P-value:3.93E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.61|P-value:1.41E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.52|P-value:6.67E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.49|P-value:2.19E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.65|P-value:5.73E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.08|P-value:1.01E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.58|P-value:1.57E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.40|P-value:9.71E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.59|P-value:7.00E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.30|P-value:4.50E-5 ID:SGTC_1772|Compound:st048439|FD-Score:-4.00|P-value:1.81E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.81|P-value:3.47E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.69|P-value:3.83E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-3.60|P-value:6.75E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.54|P-value:6.16E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.53|P-value:6.41E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.51|P-value:8.91E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.90|P-value:1.91E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.01|P-value:1.32E-4 ID:SGTC_2332|Compound:7982454|FD-Score:6.59|P-value:1.14E-9 ID:SGTC_2461|Compound:5755302|FD-Score:3.57|P-value:5.67E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.57|P-value:2.23E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.23|P-value:8.08E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.83|P-value:2.44E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.54|P-value:6.23E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.84|P-value:3.10E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-4.59|P-value:2.05E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.43|P-value:8.72E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.57|P-value:2.27E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.45|P-value:8.28E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.44|P-value:8.55E-4

Top fitness defect scores for YER135C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_998 3996-0085 6.65 177.0 µM 8.32E-10 2 1.48E-11
2 SGTC_2332 7982454 6.59 138.9 µM 1.14E-9 12 2.18E-11
3 SGTC_44 0929-0055 5.79 61.2 µM 7.28E-8 9 3.43E-9
4 SGTC_1040 k898-0338 5.66 155.0 µM 1.39E-7 3 7.55E-9
5 SGTC_1165 k072-0275 4.61 30.3 µM 1.41E-5 28 2.06E-6
6 SGTC_1565 sinapyl alcohol 4.58 95.1 µM 1.57E-5 13 2.35E-6
7 SGTC_113 0099-0221 4.55 2.5 µM 1.76E-5 14 2.69E-6
8 SGTC_1369 1866-0067 4.49 208.0 µM 2.19E-5 RPP1 & pyrimidine depletion 27 3.50E-6
9 SGTC_525 k781-2675 4.33 26.7 µM 4.05E-5 redox potentiating 47 7.37E-6
10 SGTC_1757 st041620 4.30 31.8 µM 4.50E-5 23 8.35E-6
11 SGTC_348 k064-0012 4.22 10.7 µM 6.17E-5 60S ribosome export 10 1.22E-5
12 SGTC_349 k015-0014 4.12 24.0 µM 8.78E-5 15 1.88E-5
13 SGTC_1406 3909-7906 4.08 11.9 µM 1.01E-4 60S ribosome export 8 2.21E-5
14 SGTC_948 3448-0295 4.07 75.3 µM 1.07E-4 25 2.39E-5
15 SGTC_2279 7948423 4.05 32.9 µM 1.13E-4 12 2.54E-5
16 SGTC_2302 7771753 4.01 200.0 µM 1.32E-4 42 3.07E-5
17 SGTC_20 0481-0013 3.91 4.9 µM 1.87E-4 25 4.67E-5
18 SGTC_2295 7971645 3.90 200.0 µM 1.91E-4 23 4.80E-5
19 SGTC_353 1988-1175 3.87 58.3 µM 2.09E-4 unfolded protein response 26 5.35E-5
20 SGTC_16 erodoxin 3.86 22.8 µM 2.20E-4 unfolded protein response 67 5.69E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.46E-15 YDL109C_p YDL109C_p hom Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
0.079 5.19E-6 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.078 6.70E-6 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.078 6.92E-6 YJR109C CPA2 hom Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
0.077 7.68E-6 YER130C_p YER130C_p hom Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress
0.077 8.08E-6 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.075 1.32E-5 YCR075C ERS1 hom Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
0.075 1.44E-5 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.071 3.87E-5 YPR196W_p YPR196W_p hom Putative maltose-responsive transcription factor
0.070 4.37E-5 YOR118W RTC5 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
0.069 5.66E-5 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.069 5.86E-5 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.069 5.91E-5 YOL093W TRM10 hom tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress
0.068 7.18E-5 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.068 8.56E-5 YER119C AVT6 hom Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication