YER136W / GDI1

GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER136W / GDI1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-3.38|P-value:4.33E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.86|P-value:2.59E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.74|P-value:1.11E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:2.69|P-value:7.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.41|P-value:9.95E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.81|P-value:4.49E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.80|P-value:3.59E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:5.40|P-value:9.81E-11 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.42|P-value:1.31E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.29|P-value:4.98E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.55|P-value:1.38E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:-4.06|P-value:1.16E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:3.62|P-value:9.55E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.13|P-value:7.70E-10 ID:SGTC_626|Compound:0214-0009|FD-Score:3.27|P-value:5.67E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.04|P-value:9.55E-7 ID:SGTC_749|Compound:1000-0129|FD-Score:3.53|P-value:1.52E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.08|P-value:1.72E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-8.04|P-value:3.03E-21 ID:SGTC_786|Compound:4544-0069|FD-Score:2.78|P-value:4.91E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:2.67|P-value:7.91E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.32|P-value:1.71E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.57|P-value:1.65E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.63|P-value:9.16E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.90|P-value:3.77E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.34|P-value:3.91E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:2.75|P-value:5.56E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.10|P-value:6.70E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.34|P-value:3.98E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.71|P-value:6.55E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-2.74|P-value:7.33E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.89|P-value:4.04E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.39|P-value:3.10E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-3.09|P-value:1.70E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.08|P-value:1.76E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.01|P-value:1.72E-9 ID:SGTC_2179|Compound:6298986|FD-Score:-2.80|P-value:5.74E-4 ID:SGTC_2191|Compound:5911152|FD-Score:2.89|P-value:3.18E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.36|P-value:1.32E-7 ID:SGTC_2257|Compound:7960413|FD-Score:3.15|P-value:9.70E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.51|P-value:1.67E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.34|P-value:4.00E-5 ID:SGTC_2426|Compound:5582046|FD-Score:2.98|P-value:2.14E-4 ID:SGTC_2475|Compound:5812728|FD-Score:2.73|P-value:6.15E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.29|P-value:5.14E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.48|P-value:2.58E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.35|P-value:3.70E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.60|P-value:1.09E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.21|P-value:9.58E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.17|P-value:1.18E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.00|P-value:2.45E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.08|P-value:1.38E-4 ID:SGTC_3322|Compound:9139058|FD-Score:2.66|P-value:8.26E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.38|P-value:4.33E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.86|P-value:2.59E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.74|P-value:1.11E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:2.69|P-value:7.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.41|P-value:9.95E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.81|P-value:4.49E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.80|P-value:3.59E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:5.40|P-value:9.81E-11 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.42|P-value:1.31E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.29|P-value:4.98E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.55|P-value:1.38E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:-4.06|P-value:1.16E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:3.62|P-value:9.55E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.13|P-value:7.70E-10 ID:SGTC_626|Compound:0214-0009|FD-Score:3.27|P-value:5.67E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.04|P-value:9.55E-7 ID:SGTC_749|Compound:1000-0129|FD-Score:3.53|P-value:1.52E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.08|P-value:1.72E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-8.04|P-value:3.03E-21 ID:SGTC_786|Compound:4544-0069|FD-Score:2.78|P-value:4.91E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:2.67|P-value:7.91E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.32|P-value:1.71E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.57|P-value:1.65E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.63|P-value:9.16E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.90|P-value:3.77E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.34|P-value:3.91E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:2.75|P-value:5.56E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.10|P-value:6.70E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.34|P-value:3.98E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.71|P-value:6.55E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-2.74|P-value:7.33E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.89|P-value:4.04E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.39|P-value:3.10E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-3.09|P-value:1.70E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.08|P-value:1.76E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.01|P-value:1.72E-9 ID:SGTC_2179|Compound:6298986|FD-Score:-2.80|P-value:5.74E-4 ID:SGTC_2191|Compound:5911152|FD-Score:2.89|P-value:3.18E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.36|P-value:1.32E-7 ID:SGTC_2257|Compound:7960413|FD-Score:3.15|P-value:9.70E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.51|P-value:1.67E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.34|P-value:4.00E-5 ID:SGTC_2426|Compound:5582046|FD-Score:2.98|P-value:2.14E-4 ID:SGTC_2475|Compound:5812728|FD-Score:2.73|P-value:6.15E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.29|P-value:5.14E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.48|P-value:2.58E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.35|P-value:3.70E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.60|P-value:1.09E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.21|P-value:9.58E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.17|P-value:1.18E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.00|P-value:2.45E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.08|P-value:1.38E-4 ID:SGTC_3322|Compound:9139058|FD-Score:2.66|P-value:8.26E-4

Top fitness defect scores for YER136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_382 3229-0966 5.40 23.2 µM 9.81E-11 1 3.27E-8 0.58
2 SGTC_568 1193-0097 5.13 7.5 µM 7.70E-10 ERAD & cell cycle 16 1.47E-7 0.12
3 SGTC_1968 st069590 5.01 43.6 µM 1.72E-9 10 2.65E-7 0.17
4 SGTC_236 1509-0011 4.41 5.3 µM 9.95E-8 23 5.16E-6 0.12
5 SGTC_2249 haloperidol 4.36 116.4 µM 1.32E-7 ergosterol depletion effects on membrane 31 6.37E-6 0.05
6 SGTC_911 3456-4043 4.32 236.0 µM 1.71E-7 mitochondrial processes 10 7.68E-6 0.04
7 SGTC_1228 0124-0032 4.10 52.5 µM 6.70E-7 2 2.09E-5 0.16
8 SGTC_637 1181-0519 4.04 7.3 µM 9.55E-7 fatty acid desaturase (OLE1) 10 2.71E-5 0.24
9 SGTC_75 0159-0059 3.86 199.0 µM 2.59E-6 fatty acid desaturase (OLE1) 12 5.63E-5 0.22
10 SGTC_308 4092-1169 3.80 104.0 µM 3.59E-6 plasma membrane duress 8 7.17E-5 0.17
11 SGTC_556 4058-0063 3.62 51.5 µM 9.55E-6 9 1.47E-4 0.35
12 SGTC_2968 9090663 3.60 33.4 µM 1.09E-5 17 1.62E-4 0.01
13 SGTC_417 st075190 3.55 100.0 µM 1.38E-5 2 1.93E-4 0.14
14 SGTC_749 1000-0129 3.53 128.0 µM 1.52E-5 amide catabolism 4 2.07E-4 0.16
15 SGTC_2336 9001819 3.51 198.7 µM 1.67E-5 heme biosynthesis & mitochondrial translocase 44 2.22E-4 0.03
16 SGTC_1859 st055998 3.39 20.0 µM 3.10E-5 11 3.50E-4 0.01
17 SGTC_2800 7887935 3.35 81.8 µM 3.70E-5 RPP1 & pyrimidine depletion 15 3.98E-4 0.10
18 SGTC_1212 0520-0165 3.34 585.0 µM 3.91E-5 8 4.15E-4 0.01
19 SGTC_1246 0422-0085 3.34 105.0 µM 3.98E-5 15 4.20E-4 0.06
20 SGTC_2395 5646831 3.34 180.2 µM 4.00E-5 6 4.21E-4 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.44E-42 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.188 3.51E-28 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.167 2.59E-22 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.153 3.89E-19 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.145 3.25E-17 YKL111C_d YKL111C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.142 1.30E-16 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.136 2.75E-15 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.134 5.66E-15 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.133 8.93E-15 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.133 1.04E-14 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.132 2.03E-14 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.130 4.64E-14 YKL059C MPE1 het Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
0.129 6.72E-14 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.127 1.69E-13 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.126 2.38E-13 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2