YER137C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YER137C / YER137C

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.21|P-value:7.98E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.56|P-value:2.08E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.38|P-value:7.93E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:3.47|P-value:3.14E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.91|P-value:6.62E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.56|P-value:2.13E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.37|P-value:4.56E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:-3.22|P-value:7.18E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.61|P-value:1.78E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:4.32|P-value:1.07E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:5.51|P-value:2.85E-8 ID:SGTC_831|Compound:k061-1017|FD-Score:3.38|P-value:4.41E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.42|P-value:3.85E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.17|P-value:8.99E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.38|P-value:4.37E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.13|P-value:9.51E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.25|P-value:6.46E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.26|P-value:1.37E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:2.91E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.43|P-value:4.48E-8 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.30|P-value:8.88E-8 ID:SGTC_1849|Compound:st056239|FD-Score:3.33|P-value:5.29E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.00|P-value:4.06E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.14|P-value:2.25E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.22|P-value:7.58E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.21|P-value:7.37E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.53|P-value:2.52E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.84|P-value:4.31E-9 ID:SGTC_2339|Compound:9000433|FD-Score:4.24|P-value:1.47E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.89|P-value:7.11E-7 ID:SGTC_2447|Compound:5741742|FD-Score:3.18|P-value:8.62E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.81|P-value:8.95E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.36|P-value:8.93E-6 ID:SGTC_2484|Compound:5809818|FD-Score:3.60|P-value:1.96E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.35|P-value:9.24E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.31|P-value:5.65E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.56|P-value:2.27E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.48|P-value:2.80E-4 ID:SGTC_2865|Compound:9030313|FD-Score:5.52|P-value:2.71E-8 ID:SGTC_2877|Compound:9040724|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-4.98|P-value:4.08E-7 ID:SGTC_2924|Compound:9010168|FD-Score:-3.79|P-value:8.80E-5 ID:SGTC_3132|Compound:9126706|FD-Score:4.32|P-value:1.02E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.02|P-value:3.70E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_3240|Compound:9133527|FD-Score:4.66|P-value:2.24E-6 ID:SGTC_3263|Compound:9137018|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.47|P-value:5.33E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.21|P-value:7.98E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.56|P-value:2.08E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.38|P-value:7.93E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:3.47|P-value:3.14E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.91|P-value:6.62E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.56|P-value:2.13E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.37|P-value:4.56E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:-3.22|P-value:7.18E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.61|P-value:1.78E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:4.32|P-value:1.07E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:5.51|P-value:2.85E-8 ID:SGTC_831|Compound:k061-1017|FD-Score:3.38|P-value:4.41E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.42|P-value:3.85E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.17|P-value:8.99E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.38|P-value:4.37E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.13|P-value:9.51E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.25|P-value:6.46E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.26|P-value:1.37E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:2.91E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.43|P-value:4.48E-8 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.30|P-value:8.88E-8 ID:SGTC_1849|Compound:st056239|FD-Score:3.33|P-value:5.29E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.00|P-value:4.06E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.14|P-value:2.25E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.22|P-value:7.58E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.21|P-value:7.37E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.53|P-value:2.52E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.84|P-value:4.31E-9 ID:SGTC_2339|Compound:9000433|FD-Score:4.24|P-value:1.47E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.89|P-value:7.11E-7 ID:SGTC_2447|Compound:5741742|FD-Score:3.18|P-value:8.62E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.81|P-value:8.95E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.36|P-value:8.93E-6 ID:SGTC_2484|Compound:5809818|FD-Score:3.60|P-value:1.96E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.35|P-value:9.24E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.31|P-value:5.65E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.56|P-value:2.27E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.48|P-value:2.80E-4 ID:SGTC_2865|Compound:9030313|FD-Score:5.52|P-value:2.71E-8 ID:SGTC_2877|Compound:9040724|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-4.98|P-value:4.08E-7 ID:SGTC_2924|Compound:9010168|FD-Score:-3.79|P-value:8.80E-5 ID:SGTC_3132|Compound:9126706|FD-Score:4.32|P-value:1.02E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.02|P-value:3.70E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_3240|Compound:9133527|FD-Score:4.66|P-value:2.24E-6 ID:SGTC_3263|Compound:9137018|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.47|P-value:5.33E-6

Top fitness defect scores for YER137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2313 7726885 5.84 200.0 µM 4.31E-9 RPP1 & pyrimidine depletion 8 2.61E-9
2 SGTC_2865 9030313 5.52 52.0 µM 2.71E-8 6 1.72E-8
3 SGTC_806 3966-4455 5.51 5.9 µM 2.85E-8 4 1.82E-8
4 SGTC_1447 4239-0816 5.43 81.9 µM 4.48E-8 6 2.89E-8
5 SGTC_1449 4112-4002 5.30 201.0 µM 8.88E-8 RPP1 & pyrimidine depletion 7 5.83E-8
6 SGTC_167 3672-0051 4.91 66.2 µM 6.62E-7 21 4.59E-7
7 SGTC_2399 5884133 4.89 200.0 µM 7.11E-7 cell wall signaling 44 4.93E-7
8 SGTC_3240 9133527 4.66 49.5 µM 2.24E-6 5 1.60E-6
9 SGTC_3274 9138298 4.47 49.5 µM 5.33E-6 13 3.90E-6
10 SGTC_39 0986-0283 4.38 58.4 µM 7.93E-6 calcium & mitochondrial duress 26 5.87E-6
11 SGTC_2479 5617353 4.36 43.9 µM 8.93E-6 25 6.63E-6
12 SGTC_2486 5283202 4.35 22.4 µM 9.24E-6 29 6.87E-6
13 SGTC_3132 9126706 4.32 49.5 µM 1.02E-5 12 7.63E-6
14 SGTC_552 k242-0005 4.32 476.0 µM 1.07E-5 10 7.96E-6
15 SGTC_1273 0849-0096 4.26 14.1 µM 1.37E-5 RPP1 & pyrimidine depletion 12 1.03E-5
16 SGTC_2339 9000433 4.24 200.0 µM 1.47E-5 30 1.11E-5
17 SGTC_1871 st057448 4.14 67.3 µM 2.25E-5 21 1.72E-5
18 SGTC_3179 9107801 4.02 49.5 µM 3.70E-5 8 2.85E-5
19 SGTC_1868 st057644 4.00 42.7 µM 4.06E-5 35 3.14E-5
20 SGTC_2460 5552655 3.81 174.2 µM 8.95E-5 amide catabolism 35 7.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.09E-10 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.096 2.56E-8 YFL017W-A SMX2 het Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
0.088 3.01E-7 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.088 3.46E-7 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.084 1.24E-6 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
0.084 1.25E-6 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.082 2.02E-6 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.081 2.41E-6 YIL073C SPO22 hom Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis
0.080 3.22E-6 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.078 6.76E-6 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.075 1.27E-5 YMR237W BCH1 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication
0.073 2.46E-5 YER046W-A_d YER046W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.94E-5 YLR258W GSY2 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.071 3.91E-5 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.071 4.18E-5 YGR147C NAT2 het Protein with an apparent role in acetylation of N-terminal methionine residues