YER143W / DDI1

DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YER143W / DDI1

Click on Significant Values for Screen Details ID:SGTC_263|Compound:alizarin|FD-Score:3.59|P-value:5.04E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.24|P-value:2.25E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.00|P-value:5.55E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.10|P-value:3.83E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.83|P-value:2.81E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:4.90|P-value:6.21E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.15|P-value:4.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.23|P-value:2.41E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:3.25|P-value:2.16E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.30|P-value:1.76E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.41|P-value:1.09E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.62|P-value:4.55E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.81|P-value:1.88E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.25|P-value:3.28E-4 ID:SGTC_1897|Compound:st060201|FD-Score:5.15|P-value:1.46E-8 ID:SGTC_2012|Compound:4023501|FD-Score:-3.37|P-value:2.04E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.22|P-value:2.40E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.04|P-value:4.87E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.01|P-value:7.33E-6 ID:SGTC_2521|Compound:angolensin|FD-Score:2.87|P-value:9.19E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.16|P-value:3.08E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:2.99|P-value:5.96E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.02|P-value:5.20E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.00|P-value:7.72E-6 ID:SGTC_2727|Compound:riluzole|FD-Score:3.26|P-value:2.05E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.53|P-value:6.55E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.67|P-value:5.80E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.82|P-value:2.91E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.39|P-value:1.05E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-4.18|P-value:5.28E-6 ID:SGTC_3083|Compound:9117465|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_3137|Compound:9097352|FD-Score:2.97|P-value:6.22E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.97|P-value:6.25E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.10|P-value:3.92E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.41|P-value:1.74E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.79|P-value:2.07E-5 ID:SGTC_3340|Compound:9146634|FD-Score:2.85|P-value:9.71E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.25|P-value:2.14E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.59|P-value:5.04E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.24|P-value:2.25E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.00|P-value:5.55E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.10|P-value:3.83E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.83|P-value:2.81E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:4.90|P-value:6.21E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.15|P-value:4.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.23|P-value:2.41E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:3.25|P-value:2.16E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.30|P-value:1.76E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.41|P-value:1.09E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.62|P-value:4.55E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.81|P-value:1.88E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.25|P-value:3.28E-4 ID:SGTC_1897|Compound:st060201|FD-Score:5.15|P-value:1.46E-8 ID:SGTC_2012|Compound:4023501|FD-Score:-3.37|P-value:2.04E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.22|P-value:2.40E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.04|P-value:4.87E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.01|P-value:7.33E-6 ID:SGTC_2521|Compound:angolensin|FD-Score:2.87|P-value:9.19E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.16|P-value:3.08E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:2.99|P-value:5.96E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.02|P-value:5.20E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.00|P-value:7.72E-6 ID:SGTC_2727|Compound:riluzole|FD-Score:3.26|P-value:2.05E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.53|P-value:6.55E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.67|P-value:5.80E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.82|P-value:2.91E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.39|P-value:1.05E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-4.18|P-value:5.28E-6 ID:SGTC_3083|Compound:9117465|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_3137|Compound:9097352|FD-Score:2.97|P-value:6.22E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.97|P-value:6.25E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.10|P-value:3.92E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.41|P-value:1.74E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.79|P-value:2.07E-5 ID:SGTC_3340|Compound:9146634|FD-Score:2.85|P-value:9.71E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.25|P-value:2.14E-4

Top fitness defect scores for YER143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1897 st060201 5.15 15.0 µM 1.46E-8 mitochondrial processes 10 1.32E-7
2 SGTC_919 tnp00227 4.90 403.6 nM 6.21E-8 RNA pol III & RNase P/MRP 13 4.69E-7
3 SGTC_2952 9073731 4.39 13.8 µM 1.05E-6 tubulin folding & SWR complex 25 5.54E-6
4 SGTC_969 1313-0238 4.23 134.0 µM 2.41E-6 mitochondrial processes 18 1.15E-5
5 SGTC_2520 obtusaquinone 4.01 4.7 µM 7.33E-6 18 3.04E-5
6 SGTC_2702 st077768 4.00 96.8 µM 7.72E-6 15 3.17E-5
7 SGTC_1460 k062-0059 3.81 9.2 µM 1.88E-5 Golgi 18 6.90E-5
8 SGTC_3303 9125618 3.79 40.6 µM 2.07E-5 52 7.51E-5
9 SGTC_1349 flufenamic acid 3.62 69.0 µM 4.55E-5 22 1.50E-4
10 SGTC_263 alizarin 3.59 107.9 µM 5.04E-5 iron homeostasis 76 1.63E-4
11 SGTC_2754 granisetron 3.53 64.0 µM 6.55E-5 45 2.05E-4
12 SGTC_1288 0973-0013 3.41 65.5 µM 1.09E-4 32 3.21E-4
13 SGTC_2526 patulin 3.41 37.6 µM 1.12E-4 131 3.28E-4
14 SGTC_3083 9117465 3.40 49.5 µM 1.14E-4 39 3.35E-4
15 SGTC_1285 0929-0069 3.30 65.5 µM 1.76E-4 43 4.88E-4
16 SGTC_2727 riluzole 3.26 51.8 µM 2.05E-4 mitochondrial processes 27 5.57E-4
17 SGTC_3349 9149703 3.25 23.0 µM 2.14E-4 34 5.78E-4
18 SGTC_995 3931-2021 3.25 34.6 µM 2.16E-4 RPP1 & pyrimidine depletion 43 5.83E-4
19 SGTC_754 3474-0146 3.24 171.0 µM 2.25E-4 copper-dependent oxidative stress 52 6.05E-4
20 SGTC_2191 5911152 3.22 200.0 µM 2.40E-4 37 6.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.22E-13 YER037W PHM8 hom Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p
0.102 3.81E-9 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.097 1.99E-8 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.091 1.19E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.091 1.32E-7 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.089 2.23E-7 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.088 3.15E-7 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.088 3.30E-7 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.086 7.00E-7 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.085 7.72E-7 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.084 9.50E-7 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.082 1.77E-6 YNL095C_p YNL095C_p hom Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.078 5.44E-6 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.072 3.03E-5 YHR093W_d AHT1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
0.071 4.08E-5 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities