YER144C / UBP5

Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck

Zygosity: Homozygous strain
fixedexpanded
Profile for YER144C / UBP5

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.21|P-value:4.66E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.64|P-value:4.24E-9 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.11|P-value:6.71E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.30|P-value:3.92E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.01|P-value:9.65E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.66|P-value:8.31E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.68|P-value:8.83E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.40|P-value:2.69E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-5.19|P-value:4.62E-8 ID:SGTC_561|Compound:1550-0330|FD-Score:-4.99|P-value:1.45E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:3.07|P-value:8.81E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.25|P-value:7.27E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:4.41|P-value:3.47E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.24|P-value:7.60E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.69|P-value:8.56E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.98|P-value:2.46E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.14|P-value:6.98E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.07|P-value:8.97E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.23|P-value:8.14E-6 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.94|P-value:2.96E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.10|P-value:8.06E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.20|P-value:4.86E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.13|P-value:1.27E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.07|P-value:8.82E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.53|P-value:1.59E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.25|P-value:3.99E-4 ID:SGTC_1940|Compound:st075990|FD-Score:5.48|P-value:1.12E-8 ID:SGTC_2162|Compound:5663267|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.65|P-value:1.00E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.44|P-value:2.31E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.74|P-value:6.64E-7 ID:SGTC_2181|Compound:6316240|FD-Score:3.29|P-value:3.96E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.69|P-value:8.39E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.43|P-value:2.09E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.74|P-value:6.78E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.16|P-value:6.40E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.12|P-value:7.35E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.63|P-value:1.06E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.95|P-value:2.78E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.84|P-value:3.92E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-6.32|P-value:4.10E-11 ID:SGTC_2958|Compound:9077254|FD-Score:-3.50|P-value:1.56E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.84|P-value:4.54E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.57|P-value:1.57E-6 ID:SGTC_3263|Compound:9137018|FD-Score:3.32|P-value:3.58E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.21|P-value:4.66E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.64|P-value:4.24E-9 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.11|P-value:6.71E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.30|P-value:3.92E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.01|P-value:9.65E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.66|P-value:8.31E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.68|P-value:8.83E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.40|P-value:2.69E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-5.19|P-value:4.62E-8 ID:SGTC_561|Compound:1550-0330|FD-Score:-4.99|P-value:1.45E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:3.07|P-value:8.81E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.25|P-value:7.27E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:4.41|P-value:3.47E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.24|P-value:7.60E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.69|P-value:8.56E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.98|P-value:2.46E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.14|P-value:6.98E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.07|P-value:8.97E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.23|P-value:8.14E-6 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.94|P-value:2.96E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.10|P-value:8.06E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.20|P-value:4.86E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.13|P-value:1.27E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.07|P-value:8.82E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.53|P-value:1.59E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.25|P-value:3.99E-4 ID:SGTC_1940|Compound:st075990|FD-Score:5.48|P-value:1.12E-8 ID:SGTC_2162|Compound:5663267|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.65|P-value:1.00E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.44|P-value:2.31E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.74|P-value:6.64E-7 ID:SGTC_2181|Compound:6316240|FD-Score:3.29|P-value:3.96E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.69|P-value:8.39E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.43|P-value:2.09E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.74|P-value:6.78E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.16|P-value:6.40E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.12|P-value:7.35E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.63|P-value:1.06E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.95|P-value:2.78E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.84|P-value:3.92E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-6.32|P-value:4.10E-11 ID:SGTC_2958|Compound:9077254|FD-Score:-3.50|P-value:1.56E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.84|P-value:4.54E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.57|P-value:1.57E-6 ID:SGTC_3263|Compound:9137018|FD-Score:3.32|P-value:3.58E-4

Top fitness defect scores for YER144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_166 k072-0058 5.64 166.4 µM 4.24E-9 DNA intercalators 5 8.58E-9
2 SGTC_1940 st075990 5.48 51.1 µM 1.12E-8 60S ribosome export 5 2.17E-8
3 SGTC_2171 5739187 4.74 198.1 µM 6.64E-7 copper-dependent oxidative stress 9 1.08E-6
4 SGTC_2975 9084847 4.57 53.7 µM 1.57E-6 11 2.47E-6
5 SGTC_966 1300-0360 4.41 30.2 µM 3.47E-6 heme requiring 18 5.27E-6
6 SGTC_827 3253-0474 4.25 693.0 µM 7.27E-6 12 1.07E-5
7 SGTC_1051 3253-3903 4.24 78.0 µM 7.60E-6 17 1.12E-5
8 SGTC_1292 0kpi-0043 4.23 232.0 µM 8.14E-6 10 1.19E-5
9 SGTC_1673 st016611 4.13 27.3 µM 1.27E-5 39 1.83E-5
10 SGTC_1772 st048439 4.08 82.2 µM 1.58E-5 35 2.25E-5
11 SGTC_1188 1403-0014 3.98 4.6 µM 2.46E-5 mitochondrial stress 52 3.44E-5
12 SGTC_2902 5787006 3.95 60.5 µM 2.78E-5 Golgi 27 3.88E-5
13 SGTC_1412 3909-8563 3.94 178.0 µM 2.96E-5 7 4.11E-5
14 SGTC_2966 9084041 3.84 48.0 µM 4.54E-5 37 6.20E-5
15 SGTC_2416 tofa 3.74 880.0 nM 6.78E-5 sphingolipid biosynthesis & PDR1 58 9.11E-5
16 SGTC_2185 6113692 3.69 200.0 µM 8.39E-5 ergosterol biosynthesis 22 1.12E-4
17 SGTC_1112 tnp00069 3.69 1.2 µM 8.56E-5 28 1.14E-4
18 SGTC_527 4476-4215 3.68 268.0 µM 8.83E-5 PDR1 45 1.17E-4
19 SGTC_2168 5727979 3.65 200.0 µM 1.00E-4 25 1.32E-4
20 SGTC_2838 9002687 3.63 71.4 µM 1.06E-4 fatty acid desaturase (OLE1) 27 1.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.18E-10 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.094 5.35E-8 YGL027C CWH41 hom Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.093 6.10E-8 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.086 6.44E-7 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.085 7.15E-7 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.29E-6 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.083 1.64E-6 YPL180W TCO89 hom Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
0.083 1.73E-6 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.27E-6 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.081 2.72E-6 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.079 4.97E-6 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.079 5.18E-6 YML096W_p YML096W_p hom Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
0.078 5.77E-6 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.078 6.57E-6 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.074 1.65E-5 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data